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Research ArticlePediatrics

Pediatric Atypical Teratoid/Rhabdoid Tumors of the Brain: Identification of Metabolic Subgroups Using In Vivo 1H-MR Spectroscopy

B. Tamrazi, S. Venneti, A. Margol, D. Hawes, S.Y. Cen, M. Nelson, A. Judkins, J. Biegel and S. Blüml
American Journal of Neuroradiology May 2019, 40 (5) 872-877; DOI: https://doi.org/10.3174/ajnr.A6024
B. Tamrazi
aFrom the Departments of Radiology (B.T., M.N., S.B.)
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S. Venneti
dDepartment of Pathology (S.V.), University of Michigan, Ann Arbor, Michigan
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A. Margol
bPediatrics (A.M.) and Division of Hematology Oncology
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D. Hawes
cPathology (D.H., A.J., J.B.), Children's Hospital Los Angeles, Los Angeles, California
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S.Y. Cen
eDepartment of Radiology and Neurology (S.Y.C.), University of Southern California, Los Angeles, California
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M. Nelson
aFrom the Departments of Radiology (B.T., M.N., S.B.)
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  • ORCID record for M. Nelson
A. Judkins
cPathology (D.H., A.J., J.B.), Children's Hospital Los Angeles, Los Angeles, California
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J. Biegel
cPathology (D.H., A.J., J.B.), Children's Hospital Los Angeles, Los Angeles, California
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S. Blüml
aFrom the Departments of Radiology (B.T., M.N., S.B.)
fRudi Schulte Research Institute (S.B.), Santa Barbara, California.
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REFERENCES

  1. 1.↵
    1. Ostrom QT,
    2. Gittleman H,
    3. Fulop J, et al
    . CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008–2012. Neuro Oncol 2015;17(Suppl 4):iv1–62 doi:10.1093/neuonc/nov189 pmid:26511214
    CrossRefPubMed
  2. 2.↵
    1. Ries L,
    2. Smith M,
    3. Gurney J, et al
    1. Gurney J,
    2. Smith M,
    3. Bunin G
    . CNS and miscellaneous intracranial and intraspinal neoplasms. In: Ries L, Smith M, Gurney J, et al., eds. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975–1995. Bethesda: National Cancer Institute, SEER Program. NIH Pub. No. 99–4649; 1999
  3. 3.↵
    1. Biegel JA,
    2. Zhou JY,
    3. Rorke LB, et al
    . Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. Cancer Res 1999;59:74–79 pmid:9892189
    Abstract/FREE Full Text
  4. 4.↵
    1. Versteege I,
    2. Sévenet N,
    3. Lange J, et al
    . Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature 1998;394:203–06 doi:10.1038/28212 pmid:9671307
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Richardson EA,
    2. Ho B,
    3. Huang A
    . Atypical teratoid rhabdoid tumour: from tumours to therapies. J Korean Neurosurg Soc 2018;61:302–11 doi:10.3340/jkns.2018.0061 pmid:29742888
    CrossRefPubMed
  6. 6.↵
    1. Ginn KF,
    2. Gajjar A
    . Atypical teratoid rhabdoid tumor: current therapy and future directions. Front Oncol 2012;2:114 doi:10.3389/fonc.2012.00114 pmid:22988546
    CrossRefPubMed
  7. 7.↵
    1. Torchia J,
    2. Golbourn B,
    3. Feng S, et al
    . Integrated (epi)-genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors. Cancer Cell 2016;30:891–908 doi:10.1016/j.ccell.2016.11.003 pmid:27960086
    CrossRefPubMed
  8. 8.↵
    1. Johann PD,
    2. Erkek S,
    3. Zapatka M, et al
    . Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes. Cancer Cell 2016;29:379–93 doi:10.1016/j.ccell.2016.02.001 pmid:26923874
    CrossRefPubMed
  9. 9.↵
    1. Nowak J,
    2. Nemes K,
    3. Hohm A, et al
    . Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor. Neuro Oncol 2018;20:1672–79 doi:10.1093/neuonc/noy111 pmid:30010851
    CrossRefPubMed
  10. 10.↵
    1. Torchia J,
    2. Picard D,
    3. Lafay-Cousin L, et al
    . Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis. Lancet Oncol 2015;16:569–82 doi:10.1016/S1470-2045(15)70114-2 pmid:25882982
    CrossRefPubMed
  11. 11.↵
    1. Eaton KW,
    2. Tooke LS,
    3. Wainwright LM, et al
    . Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors. Pediatr Blood Cancer 2011;56:7–15 doi:10.1002/pbc.22831 pmid:21108436
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Panwalkar P,
    2. Clark J,
    3. Ramaswamy V, et al
    . Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome. Acta Neuropathol 2017;134:705–14 doi:10.1007/s00401-017-1752-4 pmid:28733933
    CrossRefPubMed
  13. 13.↵
    1. Venneti S,
    2. Le P,
    3. Martinez D, et al
    . Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins. Am J Surg Pathol 2011;35:1463–72 doi:10.1097/PAS.0b013e318224d2cd pmid:21921784
    CrossRefPubMed
  14. 14.↵
    1. Eaton BT,
    2. Hyatt AD,
    3. Brookes SM
    . The replication of bluetongue virus. Curr Top Microbiol Immunol 1990;162:89–118 pmid:2166649
    PubMedWeb of Science
  15. 15.↵
    1. Venneti S,
    2. Garimella MT,
    3. Sullivan LM, et al
    . Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas. Brain Pathol 2013;23:558–64 doi:10.1111/bpa.12042 pmid:23414300
    CrossRefPubMed
  16. 16.↵
    FDA. Multiple Endpoints in Clinical Trials. 2017. https://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm536750.pdf. Accessed September 18, 2018.
  17. 17.↵
    1. Hanna-El-Daher L,
    2. Braissant O
    . Creatine synthesis and exchanges between brain cells: what can be learned from human creatine deficiencies and various experimental models? Amino Acids 2016;48:1877–95 doi:10.1007/s00726-016-2189-0 pmid:26861125
    CrossRefPubMed
  18. 18.↵
    1. Braissant O,
    2. Henry H,
    3. Villard AM, et al
    . Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1. BMC Dev Biol 2005;5:9 doi:10.1186/1471-213X-5-9 pmid:15918910
    CrossRefPubMed
  19. 19.↵
    1. Fisher SK,
    2. Novak JE,
    3. Agranoff BW
    . Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance. J Neurochem 2002;82:736–54 doi:10.1046/j.1471-4159.2002.01041.x pmid:12358779
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Isaacks RE,
    2. Bender AS,
    3. Kim CY, et al
    . Osmotic regulation of myo-inositol uptake in primary astrocyte cultures. Neurochem Res 1994;19:331–38 doi:10.1007/BF00971582 pmid:8177373
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Brand A,
    2. Richter-Landsberg C,
    3. Leibfritz D
    . Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 1993;15:289–98 doi:10.1159/000111347 pmid:7805581
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Castillo M,
    2. Smith JK,
    3. Kwock L
    . Correlation of myo-inositol levels and grading of cerebral astrocytomas. AJNR Am J Neuroradiol 2000;21:1645–49 pmid:11039343
    Abstract/FREE Full Text
  23. 23.↵
    1. Panigrahy A,
    2. Krieger MD,
    3. Gonzalez-Gomez I, et al
    . Quantitative short echo time 1H-MR spectroscopy of untreated pediatric brain tumors: preoperative diagnosis and characterization. AJNR Am J Neuroradiol 2006;27:560–72 pmid:16551993
    Abstract/FREE Full Text
  24. 24.↵
    1. Negendank W,
    2. Sauter R
    . Intratumoral lipids in 1H MRS in vivo in brain tumors: experience of the Siemens cooperative clinical trial. Anticancer Res 1996;16:1533–38 pmid:8694522
    PubMedWeb of Science
  25. 25.↵
    1. Kuesel AC,
    2. Sutherland GR,
    3. Halliday W, et al
    . 1H MRS of high grade astrocytomas: mobile lipid accumulation in necrotic tissue. NMR Biomed 1994;7:149–55 doi:10.1002/nbm.1940070308 pmid:8080717
    CrossRefPubMed
  26. 26.↵
    1. Rock JP,
    2. Hearshen D,
    3. Scarpace L, et al
    . Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis. Neurosurgery 2002;51:912–19, discussion 919–20 pmid:12234397
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Kuesel AC,
    2. Donnelly SM,
    3. Halliday W, et al
    . Mobile lipids and metabolic heterogeneity of brain tumours as detectable by ex vivo 1H MR spectroscopy. NMR Biomed 1994;7:172–80 doi:10.1002/nbm.1940070404 pmid:7946995
    CrossRefPubMed
  28. 28.↵
    1. Jain M,
    2. Nilsson R,
    3. Sharma S, et al
    . Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 2012;336:1040–44 doi:10.1126/science.1218595 pmid:22628656
    Abstract/FREE Full Text
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B. Tamrazi, S. Venneti, A. Margol, D. Hawes, S.Y. Cen, M. Nelson, A. Judkins, J. Biegel, S. Blüml
Pediatric Atypical Teratoid/Rhabdoid Tumors of the Brain: Identification of Metabolic Subgroups Using In Vivo 1H-MR Spectroscopy
American Journal of Neuroradiology May 2019, 40 (5) 872-877; DOI: 10.3174/ajnr.A6024

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Pediatric Atypical Teratoid/Rhabdoid Tumors of the Brain: Identification of Metabolic Subgroups Using In Vivo 1H-MR Spectroscopy
B. Tamrazi, S. Venneti, A. Margol, D. Hawes, S.Y. Cen, M. Nelson, A. Judkins, J. Biegel, S. Blüml
American Journal of Neuroradiology May 2019, 40 (5) 872-877; DOI: 10.3174/ajnr.A6024
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