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Research ArticleExtracranial Vascular

Carotid CTA at the Lowest Tube Voltage (70 kV) in Comparison with Automated Tube Voltage Adaption

A. Eller, M. Wiesmüller, W. Wüst, R. Heiss, M. Kopp, M. Saake, M. Brand, M. Uder and M.M. May
American Journal of Neuroradiology August 2019, 40 (8) 1374-1382; DOI: https://doi.org/10.3174/ajnr.A6108
A. Eller
aFrom the Department of Radiology (A.E., M.W., W.W., R.H., M.K., M.S., M.B., M.U., M.M.M.), University Hospital Erlangen, Erlangen, Germany
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M. Wiesmüller
aFrom the Department of Radiology (A.E., M.W., W.W., R.H., M.K., M.S., M.B., M.U., M.M.M.), University Hospital Erlangen, Erlangen, Germany
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W. Wüst
aFrom the Department of Radiology (A.E., M.W., W.W., R.H., M.K., M.S., M.B., M.U., M.M.M.), University Hospital Erlangen, Erlangen, Germany
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R. Heiss
aFrom the Department of Radiology (A.E., M.W., W.W., R.H., M.K., M.S., M.B., M.U., M.M.M.), University Hospital Erlangen, Erlangen, Germany
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M. Kopp
aFrom the Department of Radiology (A.E., M.W., W.W., R.H., M.K., M.S., M.B., M.U., M.M.M.), University Hospital Erlangen, Erlangen, Germany
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M. Saake
aFrom the Department of Radiology (A.E., M.W., W.W., R.H., M.K., M.S., M.B., M.U., M.M.M.), University Hospital Erlangen, Erlangen, Germany
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M. Brand
aFrom the Department of Radiology (A.E., M.W., W.W., R.H., M.K., M.S., M.B., M.U., M.M.M.), University Hospital Erlangen, Erlangen, Germany
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M. Uder
aFrom the Department of Radiology (A.E., M.W., W.W., R.H., M.K., M.S., M.B., M.U., M.M.M.), University Hospital Erlangen, Erlangen, Germany
bImaging Science Institute (M.U., M.M.M.), Erlangen, Germany.
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M.M. May
aFrom the Department of Radiology (A.E., M.W., W.W., R.H., M.K., M.S., M.B., M.U., M.M.M.), University Hospital Erlangen, Erlangen, Germany
bImaging Science Institute (M.U., M.M.M.), Erlangen, Germany.
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    Fig 1.

    Coronal maximum intensity projection (5 mm) of a patient with obesity from the study group (BMI, 30.4 kg/m2; 70 kV) provides an overview of the evaluated artifacts (arrows) at the level of the skull base, shoulders, and venous contrast agent inflow (A). Axial examples of mild artifacts not affecting the diagnosis (Likert 3) in patients from the study (70 kV, B1–B3) and the control group (80 kV, C1–C3). Note the distinct increase at the lowest tube voltages that did not affect the rating.

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    Fig 2.

    CT of a 51-year-old female patient of the study group (BMI, 25.4 kg/m2): curved MPR of the right side in 3 planes; 2.5-mm slice thickness; window level, 900 HU, and center, 200 HU. High vessel contrast with excellent overall image quality (Likert 4), moderate stenosis of the internal carotid artery (NASCET 2), and artifacts from dental implants not affecting the diagnosis (Likert 2). CTDIvol was 2.92 mGy, and DLP was 108 mGy × cm.

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    Fig 3.

    CT imaging of a 60-year-old male patient of the control group (BMI 25.7 kg/m2) curved MPR of the right side in 3 planes; 2.5-mm slice thickness; window level, 900 HU, and center, 200 HU. Intermediate vessel contrast with excellent overall image quality (Likert 4), severe stenosis of the internal carotid artery (NASCET 3), and artifacts from dental implants not affecting the diagnosis (Likert 2). CTDIvol was 4.01 mGy, and DLP was 146 mGy × cm.

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    Fig 4.

    CT of a 69-year-old male patient of the control group (BMI, 31.6 kg/m2): curved MPR of the left side in 3 planes; 2.5-mm slice thickness; window level, 900 HU, and center, 200 HU. Low vessel contrast with excellent overall image quality (Likert 4), moderate stenosis of the internal carotid artery (NASCET 2), and artifacts from dental implants not affecting the diagnosis (Likert 2). The CTDIvol was 5.74 mGy, and the DLP was 202 mGy × cm.

Tables

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    Table 1:

    Results of measurements and dose exposurea

    StudyControl
    CompleteSubgroupsCompleteSubgroups
    BMI <27BMI >2770 kV80 kV90 kV
    No.4529164519206
    BMI (kg/m2)25 ± 4.722 ± 2.730.4 ± 225.9 ± 4.123.6 ± 3.526.4 ± 3.231.4 ± 2.6
    Ref. mAs167167167NA167125104
    Eff. mAs235 ± 52213 ± 35274 ± 57bcNA225 ± 26200 ± 23182 ± 16
    CTDIvol (mGy)2.9 ± 12.7 ± 0.43.4 ± 0.7bc3.7 ± 1bd2.8 ± 0.34.1 ± 0.4bd5.6 ± 0.6bd
    DLP (mGy × cm)107 ± 2595 ± 15127 ± 28bc133 ± 47bd96 ± 13bc150 ± 41bd200 ± 26bd
    ED (mSv)0.56 ± 0.130.5 ± 0.080.66 ± 0.150.70 ± 0.24bd0.50 ± 0.06bc0.78 ± 0.21bd1.04 ± 0.13bd
    ROI carotid
        A (HU)482 ± 173496 ± 183457 ± 155515 ± 172644 ± 131bd460 ± 115287 ± 107bc
        SD (HU)10 ± 310 ± 410 ± 211 ± 4bc12 ± 4bc11 ± 311 ± 3
        C (HU)419 ± 171434 ± 183391 ± 150456 ± 169581 ± 128bd407 ± 115224 ± 105bc
        SNR52 ± 2555 ± 2747 ± 2150 ± 3064 ± 1345 ± 1527 ± 12bc
        CNR45 ± 2448 ± 2640 ± 2044 ± 2856 ± 3640 ± 1421 ± 10bc
        CNRD (mGy−1/2)26.9 ± 1529.9 ± 1622.1 ± 1222.4 ± 1729.7 ± 1219.8 ± 7bc8.8 ± 4bd
    ROI muscle
        A (HU)63 ± 1261 ± 1267 ± 1469 ± 5664 ± 1358 ± 11bc63 ± 4
        SD (HU)8 ± 37 ± 310 ± 3bc8 ± 38 ± 38 ± 39 ± 3
    ROI air
        A (HU)−998 ± 7−998 ± 5−998 ± 4−999 ± 5−998 ± 5−1000 ± 5−1000 ± 6
        SD (HU)4 ± 24 ± 15 ± 1bc5 ± 14 ± 14 ± 15 ± 1
    • Note:—No. indicates sample size; ED, effective dose; NA, not applicable; Ref., reference; Eff. mAs, effective mAs; A, relative attenuation.

    • ↵a BMI-related subgroups from the study group are compared with each other; tube voltage–related subgroups of the control group are compared with the study group.

    • ↵b Significant difference.

    • ↵c P < .05.

    • ↵d P < .001.

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    Table 2:

    Grading numbers in the subjective image analysisa

    GradeImage QualityArtifacts (CM-Influx)Artifacts (Shoulder)Artifacts (Skull)Artifacts (Dental Hardware)
    StudyControlStudyControlStudyControlStudyControlStudyControl
    43836111500001413
    37822234345424335
    20112720322725
    10000000012
    • Note:—CM indicates contrast medium; meant are the artifacts by highly-concentrated inflowing contrast medium in the subclavian vein.

    • ↵a Each group (n = 45).

    • View popup
    Table 3:

    Results of the diagnostic evaluation

    GroupStudyControl
    CompleteSubgroupsCompleteSubgroups
    BMI <27BMI >2770 kV80 kV90 kV
    No.4529164519206
    Right superior thyroid artery3.63.63.73.43.33.63.2
    Right lingual artery3.73.63.83.73.63.93.5
    Right facial artery3.23.13.53.23.13.33
    Left superior thyroid artery3.43.23.83.53.53.63.2
    Left lingual artery3.73.73.83.73.83.83.3
    Left facial artery3.23.13.43.23.33.23.2
    Calcification, right carotid artery2.22.12.32.32.22.22.7
    Calcification, left carotid artery2.12.02.32.01.92.02.7
    Stenotic disease, right carotid artery0.60.50.80.50.51.10.7
    Stenotic disease, left carotid artery0.40.30.60.80.10.81.2
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American Journal of Neuroradiology: 40 (8)
American Journal of Neuroradiology
Vol. 40, Issue 8
1 Aug 2019
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A. Eller, M. Wiesmüller, W. Wüst, R. Heiss, M. Kopp, M. Saake, M. Brand, M. Uder, M.M. May
Carotid CTA at the Lowest Tube Voltage (70 kV) in Comparison with Automated Tube Voltage Adaption
American Journal of Neuroradiology Aug 2019, 40 (8) 1374-1382; DOI: 10.3174/ajnr.A6108

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Carotid CTA at the Lowest Tube Voltage (70 kV) in Comparison with Automated Tube Voltage Adaption
A. Eller, M. Wiesmüller, W. Wüst, R. Heiss, M. Kopp, M. Saake, M. Brand, M. Uder, M.M. May
American Journal of Neuroradiology Aug 2019, 40 (8) 1374-1382; DOI: 10.3174/ajnr.A6108
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