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Research ArticlePediatrics
Open Access

Cytotoxic Lesion of the Corpus Callosum in an Adolescent with Multisystem Inflammatory Syndrome and SARS-CoV-2 Infection

J. Lin, E.C. Lawson, S. Verma, R.B. Peterson and R. Sidhu
American Journal of Neuroradiology November 2020, 41 (11) 2017-2019; DOI: https://doi.org/10.3174/ajnr.A6755
J. Lin
aFrom the Department of Pediatric Neurology (J.L., E.C.L., S.V., R.S.), Children’s Healthcare of Atlanta, Atlanta, Georgia
dDepartment of Pediatrics (J.L., S.V., R.S.), Division of Neurology, Emory University School of Medicine, Atlanta, Georgia
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E.C. Lawson
aFrom the Department of Pediatric Neurology (J.L., E.C.L., S.V., R.S.), Children’s Healthcare of Atlanta, Atlanta, Georgia
cDivision of Neuroradiology, Department of Neurology (E.C.L.)
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S. Verma
aFrom the Department of Pediatric Neurology (J.L., E.C.L., S.V., R.S.), Children’s Healthcare of Atlanta, Atlanta, Georgia
dDepartment of Pediatrics (J.L., S.V., R.S.), Division of Neurology, Emory University School of Medicine, Atlanta, Georgia
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R.B. Peterson
bDepartment of Radiology and Imaging Sciences (R.B.P.)
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R. Sidhu
aFrom the Department of Pediatric Neurology (J.L., E.C.L., S.V., R.S.), Children’s Healthcare of Atlanta, Atlanta, Georgia
dDepartment of Pediatrics (J.L., S.V., R.S.), Division of Neurology, Emory University School of Medicine, Atlanta, Georgia
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    FIGURE.

    CLOCC in an adolescent with MIS-C and SARS-CoV-2.. MR image of the brain demonstrates a nonspecific focus of increased signal in the splenium of the corpus callosum on DWI sequences at b=1000 s/mm2 (black arrow, A) with associated loss of signal on apparent diffusion coefficient maps (white arrow, B) corresponding to restricted diffusion. The apparent diffusion coefficient for the lesion is 0.44 × 10−3 mm2/s. This lesion corresponds to a faint focus of abnormal increased signal on T2WI spin-echo sequences (black arrowhead, C). The lesion also demonstrates a lack of contrast enhancement on T1WI postcontrast thin-section image (D) and absent susceptibility, suggesting absent hemorrhage on SWI (E). The imaging findings suggest a cytotoxic lesion of the corpus callosum. Follow-up DWI (F) and ADC maps (G) with T2WI (H), T1WI (I), and SWI sequences (J) after 2.5 months demonstrate resolution of the lesion after therapy.

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American Journal of Neuroradiology: 41 (11)
American Journal of Neuroradiology
Vol. 41, Issue 11
1 Nov 2020
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J. Lin, E.C. Lawson, S. Verma, R.B. Peterson, R. Sidhu
Cytotoxic Lesion of the Corpus Callosum in an Adolescent with Multisystem Inflammatory Syndrome and SARS-CoV-2 Infection
American Journal of Neuroradiology Nov 2020, 41 (11) 2017-2019; DOI: 10.3174/ajnr.A6755

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Cytotoxic Lesion of the Corpus Callosum in an Adolescent with Multisystem Inflammatory Syndrome and SARS-CoV-2 Infection
J. Lin, E.C. Lawson, S. Verma, R.B. Peterson, R. Sidhu
American Journal of Neuroradiology Nov 2020, 41 (11) 2017-2019; DOI: 10.3174/ajnr.A6755
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