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Research ArticleAdult Brain
Open Access

COVID-19 and Involvement of the Corpus Callosum: Potential Effect of the Cytokine Storm?

C. Rasmussen, I. Niculescu, S. Patel and A. Krishnan
American Journal of Neuroradiology September 2020, 41 (9) 1625-1628; DOI: https://doi.org/10.3174/ajnr.A6680
C. Rasmussen
aFrom the Departments of Diagnostic Radiology and Molecular Imaging (C.R., S.P., A.K.), and Internal Medicine (IN), Beaumont Health, Royal Oak, Michigan
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I. Niculescu
aFrom the Departments of Diagnostic Radiology and Molecular Imaging (C.R., S.P., A.K.), and Internal Medicine (IN), Beaumont Health, Royal Oak, Michigan
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S. Patel
aFrom the Departments of Diagnostic Radiology and Molecular Imaging (C.R., S.P., A.K.), and Internal Medicine (IN), Beaumont Health, Royal Oak, Michigan
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A. Krishnan
aFrom the Departments of Diagnostic Radiology and Molecular Imaging (C.R., S.P., A.K.), and Internal Medicine (IN), Beaumont Health, Royal Oak, Michigan
bOakland University William Beaumont School of Medicine (A.K.), Rochester, Michigan.
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  • FIG 1.
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    FIG 1.

    Initial noncontrast head CT images demonstrate hypodensities in the left posterior parietal (black arrows) and peritrigonal regions as well as the corpus collosum (white arrows). No evidence of hemorrhage, mass effect, or midline shift is seen at this time.

  • FIG 2.
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    FIG 2.

    Subsequent head CT demonstrates hemorrhage (white arrows) within the previously seen hypodensities. The posterior corpus collosum is involved.

  • FIG 3.
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    FIG 3.

    Multiple diffusion-weighted images demonstrate restriction centered in the corpus collosum (white arrows), with some additional areas in the adjacent deep white matter including the centrum semiovale. In addition, there is faint diffusion restriction in the left occipital and temporal lobes, possibly representing subacute strokes. The thalami, brain stem, and cerebellum are spared.

  • FIG 4.
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    FIG 4.

    A, Sagittal T1. Hypointense signal within the corpus collosum, most prominent in the splenium. B, Axial T2* sequence. Multiple punctate hypointensities compatible with hemorrhages are present within the corpus collosum (white arrow) and optic radiations, which are not shown. Axial (C) and coronal (D) T2 FLAIR. Increased T2 signal is seen with the corpus callosum (black arrows).

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American Journal of Neuroradiology: 41 (9)
American Journal of Neuroradiology
Vol. 41, Issue 9
1 Sep 2020
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Cite this article
C. Rasmussen, I. Niculescu, S. Patel, A. Krishnan
COVID-19 and Involvement of the Corpus Callosum: Potential Effect of the Cytokine Storm?
American Journal of Neuroradiology Sep 2020, 41 (9) 1625-1628; DOI: 10.3174/ajnr.A6680

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COVID-19 and Involvement of the Corpus Callosum: Potential Effect of the Cytokine Storm?
C. Rasmussen, I. Niculescu, S. Patel, A. Krishnan
American Journal of Neuroradiology Sep 2020, 41 (9) 1625-1628; DOI: 10.3174/ajnr.A6680
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  • Response by Sparr and Bieri to Letter Regarding Article, “Infarction of the Splenium of the Corpus Callosum in the Age of COVID-19: A Snapshot in Time”
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