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Research ArticlePediatrics

Selective Motor Control is a Clinical Correlate of Brain Motor Tract Impairment in Children with Spastic Bilateral Cerebral Palsy

A. Vuong, E.G. Fowler, J. Matsumoto, L.A. Staudt, H. Yokota and S.H. Joshi
American Journal of Neuroradiology November 2021, 42 (11) 2054-2061; DOI: https://doi.org/10.3174/ajnr.A7272
A. Vuong
aFrom the Departments of Bioengineering (A.V., S.H.J.)
bOrthopaedic Surgery (A.V., E.G.F., L.A.S.)
eCenter for Cerebral Palsy at UCLA/Orthopaedic Institute for Children (A.V., E.G.F., L.A.S.), Los Angeles, California
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E.G. Fowler
bOrthopaedic Surgery (A.V., E.G.F., L.A.S.)
eCenter for Cerebral Palsy at UCLA/Orthopaedic Institute for Children (A.V., E.G.F., L.A.S.), Los Angeles, California
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J. Matsumoto
cPediatrics (J.M.)
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L.A. Staudt
bOrthopaedic Surgery (A.V., E.G.F., L.A.S.)
eCenter for Cerebral Palsy at UCLA/Orthopaedic Institute for Children (A.V., E.G.F., L.A.S.), Los Angeles, California
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H. Yokota
fDepartment of Diagnostic Radiology and Radiation (H.Y.), Chiba University Hospital, Chiba, Japan
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  • ORCID record for H. Yokota
S.H. Joshi
aFrom the Departments of Bioengineering (A.V., S.H.J.)
dAhmanson-Lovelace Brain Mapping Center in the Department of Neurology (S.H.J.), University of California Los Angeles, Los Angeles, California
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  • FIG 1.
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    FIG 1.

    TBSS results show significant differences (P <.05) in DTI measures between the CP and TDC groups. Coronal slices were selected at the level of the CST. From left to right, axial slices were selected at the level of the motor cortex, PLIC, and CerPed, respectively. Mid-sagittal slices were selected at the level of the CC. A, The WM skeleton is shown in green with arrows labeling the CST, somatosensory cortex, parietal lobe, external capsule, PLIC, anterior limb of the internal capsule (ALIC), and corpus callosum. In the coronal view, ROIs for the SCR (red), PLIC (yellow), CerPed (blue), and sub-CerPed (orange) are shown. Significant differences between the CP and TDC groups are shown for FA (B), RD (C), AD (D), and MD (E). The hot colormaps denote whether a DTI measure for the CP group was less than (red-yellow) or greater than (blue-light blue) that in the TDC group. A indicates anterior; FWE, family-wise error; I, inferior; L, left; P, posterior; R, right; S, superior.

  • FIG 2.
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    FIG 2.

    Mean differences in DTI measures between the CP and TDC groups within ROIs for the CST and CC. The asterisk indicates significant differences (P <.05). L indicates left; R, right.

  • FIG 3.
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    FIG 3.

    TBSS results show significant correlations (P <.05) between DTI measures and clinical measures for the CP group. Coronal slices were selected at the level of the CST. From left to right, axial slices were selected at the level of the motor cortex, PLIC, and CerPed, respectively. Mid-sagittal slices were selected at the level of the CC. Significant correlations are shown for FA vs. SCALE (A), FA vs. GMFM (B), RD vs. SCALE (C), and RD vs. GMFM (D). The hot colormaps denote whether the correlations were positive (red-yellow) or negative (blue-light blue). A indicates anterior; FWE, family-wise error; I, inferior; L, left; P, posterior; R, right; S, superior.

Tables

  • Figures
  • ROI correlation analyses comparing motor and whole-brain WM regions

    RegionsVoxel CountVoxels with Significant Correlations
    FA vs. SCALE (%)FA vs. GMFM (%)RD vs. SCALE (%)RD vs. GMFM (%)
    CST
     Sub-CerPed R37523 (6.1)0 (0)0 (0)0 (0)
     Sub-CerPed L3950 (0)0 (0)0 (0)0 (0)
     CerPed R598266 (44.5)0 (0)0 (0)0 (0)
     CerPed L62474 (11.9)0 (0)0 (0)0 (0)
     PLIC R845198 (23.4)74 (8.8)0 (0)0 (0)
     PLIC L85820 (2.3)18 (2.1)0 (0)0 (0)
     SCR R1294451 (34.9)387 (29.9)0 (0)0 (0)
     SCR L127994 (7.3)25 (2.0)0 (0)0 (0)
    CC
     Genu17580 (0)0 (0)54 (3.1)0 (0)
     Body31381177 (37.5)692 (22.1)874 (27.9)0 (0)
     Splenium2298904 (39.3)615 (26.8)686 (29.9)0 (0)
    Whole brain126,00038,251 (30.4)18,136 (14.4)2779 (2.2)0 (0)
    • Note:—L indicates left; R, right.

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American Journal of Neuroradiology: 42 (11)
American Journal of Neuroradiology
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A. Vuong, E.G. Fowler, J. Matsumoto, L.A. Staudt, H. Yokota, S.H. Joshi
Selective Motor Control is a Clinical Correlate of Brain Motor Tract Impairment in Children with Spastic Bilateral Cerebral Palsy
American Journal of Neuroradiology Nov 2021, 42 (11) 2054-2061; DOI: 10.3174/ajnr.A7272

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Selective Motor Control is a Clinical Correlate of Brain Motor Tract Impairment in Children with Spastic Bilateral Cerebral Palsy
A. Vuong, E.G. Fowler, J. Matsumoto, L.A. Staudt, H. Yokota, S.H. Joshi
American Journal of Neuroradiology Nov 2021, 42 (11) 2054-2061; DOI: 10.3174/ajnr.A7272
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