Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Getting new auth cookie, if you see this message a lot, tell someone!
Research ArticleSpine
Open Access

Filtered Diffusion-Weighted MRI of the Human Cervical Spinal Cord: Feasibility and Application to Traumatic Spinal Cord Injury

S.A. Murphy, R. Furger, S.N. Kurpad, V.E. Arpinar, A. Nencka, K. Koch and M.D. Budde
American Journal of Neuroradiology November 2021, 42 (11) 2101-2106; DOI: https://doi.org/10.3174/ajnr.A7295
S.A. Murphy
aFrom the Department of Neurosurgery (S.A.M., R.F., S.N.K., M.D.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.A. Murphy
R. Furger
aFrom the Department of Neurosurgery (S.A.M., R.F., S.N.K., M.D.B.)
bCenter for Neurotrauma Research (R.F., S.N.K., M.D.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Furger
S.N. Kurpad
aFrom the Department of Neurosurgery (S.A.M., R.F., S.N.K., M.D.B.)
bCenter for Neurotrauma Research (R.F., S.N.K., M.D.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.N. Kurpad
V.E. Arpinar
cCenter for Imaging Research (V.E.A., A.N., K.K.), Medical College of Wisconsin, Milwaukee, Wisconsin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for V.E. Arpinar
A. Nencka
cCenter for Imaging Research (V.E.A., A.N., K.K.), Medical College of Wisconsin, Milwaukee, Wisconsin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Nencka
K. Koch
cCenter for Imaging Research (V.E.A., A.N., K.K.), Medical College of Wisconsin, Milwaukee, Wisconsin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K. Koch
M.D. Budde
aFrom the Department of Neurosurgery (S.A.M., R.F., S.N.K., M.D.B.)
bCenter for Neurotrauma Research (R.F., S.N.K., M.D.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.D. Budde
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Zhao C,
    2. Rao JS,
    3. Pei XJ, et al
    . Longitudinal study on diffusion tensor imaging and diffusion tensor tractography following spinal cord contusion injury in rats. Neuroradiology 2016;58:607–14 doi:10.1007/s00234-016-1660-7 pmid:26931783
    CrossRefPubMed
  2. 2.↵
    1. Kim JH,
    2. Loy DN,
    3. Wang Q, et al
    . Diffusion tensor imaging at 3 hours after traumatic spinal cord injury predicts long-term locomotor recovery. J Neurotrauma 2010;27:587–98 doi:10.1089/neu.2009.1063 pmid:20001686
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Skinner NP,
    2. Kurpad SN,
    3. Schmit BD, et al
    . Rapid in vivo detection of rat spinal cord injury with double-diffusion-encoded magnetic resonance spectroscopy. Magn Reson Med 2017;77:1639–49 doi:10.1002/mrm.26243 pmid:27080726
    CrossRefPubMed
  4. 4.↵
    1. Patel SP,
    2. Smith TD,
    3. VanRooyen JL, et al
    . Serial diffusion tensor imaging in vivo predicts long-term functional recovery and histopathology in rats following different severities of spinal cord injury. J Neurotrauma 2016;33:917–28 doi:10.1089/neu.2015.4185 pmid:26650623
    CrossRefPubMed
  5. 5.↵
    1. Chiang CW,
    2. Wang Y,
    3. Sun P, et al
    . Quantifying white matter tract diffusion parameters in the presence of increased extra-fiber cellularity and vasogenic edema. Neuroimage 2014;101:310–19 doi:10.1016/j.neuroimage.2014.06.064 pmid:25017446
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Jirjis MB,
    2. Kurpad SN,
    3. Schmit BD
    . Ex vivo diffusion tensor imaging of spinal cord injury in rats of varying degrees of severity. J Neurotrauma 2013;30:1577–86 doi:10.1089/neu.2013.2897 pmid:23782233
    CrossRefPubMed
  7. 7.↵
    1. Cheran S,
    2. Shanmuganathan K,
    3. Zhuo J, et al
    . Correlation of MR diffusion tensor imaging parameters with ASIA motor scores in hemorrhagic and nonhemorrhagic acute spinal cord injury. J Neurotrauma 2011;28:1881–92 doi:10.1089/neu.2010.1741 pmid:21875333
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Cohen-Adad J,
    2. Buchbinder B,
    3. Oaklander AL
    . Cervical spinal cord injection of epidural corticosteroids: comprehensive longitudinal study including multiparametric magnetic resonance imaging. Pain 2012;153:2292–99 doi:10.1016/j.pain.2012.07.028 pmid:22964435
    CrossRefPubMed
  9. 9.↵
    1. Vedantam A,
    2. Eckardt G,
    3. Wang MC, et al
    . Clinical correlates of high cervical fractional anisotropy in acute cervical spinal cord injury. World Neurosurg 2015;83:824–28 doi:10.1016/j.wneu.2013.09.017 pmid:24055569
    CrossRefPubMed
  10. 10.↵
    1. Shanmuganathan K,
    2. Zhuo J,
    3. Bodanapally UK, et al
    . Comparison of acute diffusion tensor imaging and conventional magnetic resonance parameters in predicting long-term outcome after blunt cervical spinal cord injury. J Neurotrauma 2020;37:458–65 doi:10.1089/neu.2019.6394 pmid:31190610
    CrossRefPubMed
  11. 11.↵
    1. Budde MD,
    2. Skinner NP,
    3. Muftuler LT, et al
    . Optimizing filter-probe diffusion weighting in the rat spinal cord for human translation. Front Neurosci 2017;11:706 doi:10.3389/fnins.2017.00706 pmid:29311786
    CrossRefPubMed
  12. 12.↵
    1. Skinner NP,
    2. Kurpad SN,
    3. Schmit BD, et al
    . Detection of acute nervous system injury with advanced diffusion-weighted MRI: a simulation and sensitivity analysis. NMR Biomed 2015;28:1489–506 doi:10.1002/nbm.3405 pmid:26411743
    CrossRefPubMed
  13. 13.↵
    1. Budde MD,
    2. Frank JA
    . Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke. Proc Natl Acad Sci U S A 2010;107:14472–77 doi:10.1073/pnas.1004841107 pmid:20660718
    Abstract/FREE Full Text
  14. 14.↵
    1. Steffensen AB,
    2. Sword J,
    3. Croom D, et al
    . Chloride cotransporters as a molecular mechanism underlying spreading depolarization-induced dendritic beading. J Neurosci 2015;35:12172–87 doi:10.1523/JNEUROSCI.0400-15.2015 pmid:26338328
    Abstract/FREE Full Text
  15. 15.↵
    1. Sundberg LM,
    2. Herrera JJ,
    3. Narayana PA
    . In vivo longitudinal MRI and behavioral studies in experimental spinal cord injury. J Neurotrauma 2010;27:1753–67 doi:10.1089/neu.2010.1369 pmid:20649481
    CrossRefPubMed
  16. 16.↵
    1. Sliker CW,
    2. Mirvis SE,
    3. Shanmuganathan K
    . Assessing cervical spine stability in obtunded blunt trauma patients: review of medical literature. Radiology 2005;234:733–39 doi:10.1148/radiol.2343031768 pmid:15734929
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Leypold BG,
    2. Flanders AE,
    3. Schwartz ED, et al
    . The impact of methylprednisolone on lesion severity following spinal cord injury. Spine (Phila Pa 1976) 2007;32:373–78; discussion 379–81 doi:10.1097/01.brs.0000253964.10701.00] pmid:17268271
    CrossRefPubMed
  18. 18.↵
    1. Biering-Sørensen F,
    2. Alai S,
    3. Anderson K, et al
    . Common data elements for spinal cord injury clinical research: a National Institute for Neurological Disorders and Stroke project. Spinal Cord 2015;53:265–77 doi:10.1038/sc.2014.246 pmid:25665542
    CrossRefPubMed
  19. 19.↵
    1. Surey S,
    2. Berry M,
    3. Logan A, et al
    . Differential cavitation, angiogenesis and wound-healing responses in injured mouse and rat spinal cords. Neuroscience 2014;275:62–80 doi:10.1016/j.neuroscience.2014.06.003 pmid:24929066
    CrossRefPubMed
  20. 20.↵
    1. Medana IM,
    2. Esiri MM
    . Axonal damage: a key predictor of outcome in human CNS diseases. Brain 2003;126:515–30 doi:10.1093/brain/awg061 pmid:12566274
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Fieremans E,
    2. Jensen JH,
    3. Helpern JA
    . White matter characterization with diffusional kurtosis imaging. Neuroimage 2011;58:177–88 doi:10.1016/j.neuroimage.2011.06.006 pmid:21699989
    CrossRefPubMed
  22. 22.↵
    1. Shanmuganathan K,
    2. Zhuo J,
    3. Chen HH, et al
    . Diffusion tensor imaging parameter obtained during acute blunt cervical spinal cord injury in predicting long-term outcome. J Neurotrauma 2017;34:2964–71 doi:10.1089/neu.2016.4901 pmid:28385062
    CrossRefPubMed
  23. 23.↵
    1. Leypold BG,
    2. Flanders AE,
    3. Burns AS
    . The early evolution of spinal cord lesions on MR imaging following traumatic spinal cord injury. AJNR Am J Neuroradiol 2008;29:1012–16 doi:10.3174/ajnr.A0962 pmid:18296550
    CrossRefPubMed
  24. 24.↵
    1. Williams PR,
    2. Marincu BN,
    3. Sorbara CD, et al
    . A recoverable state of axon injury persists for hours after spinal cord contusion in vivo. Nat Commun 2014;5:5683 doi:10.1038/ncomms6683 pmid:25511170
    CrossRefPubMed
  25. 25.↵
    1. Grussu F,
    2. Schneider T,
    3. Zhang H, et al
    . Neurite orientation dispersion and density imaging of the healthy cervical spinal cord in vivo. Neuroimage 2015;111:590–601 doi:10.1016/j.neuroimage.2015.01.045 pmid:25652391
    CrossRefPubMed
  26. 26.↵
    1. By S,
    2. Xu J,
    3. Box BA, et al
    . Application and evaluation of NODDI in the cervical spinal cord of multiple sclerosis patients. Neuroimage Clin 2017;15:333–42 doi:10.1016/j.nicl.2017.05.010 pmid:28560158
    CrossRefPubMed
  27. 27.↵
    1. Budde MD,
    2. Skinner NP
    . Diffusion MRI in acute nervous system injury. J Magn Reson 2018;292:137–48 doi:10.1016/j.jmr.2018.04.016 pmid:29773299
    CrossRefPubMed
  28. 28.↵
    1. Nukala M,
    2. Abraham J,
    3. Khandige G, et al
    . Efficacy of diffusion tensor imaging in identification of degenerative cervical spondylotic myelopathy. Eur J Radiol Open 2019;6:16–23 doi:10.1016/j.ejro.2018.08.006 pmid:30581892
    CrossRefPubMed
  29. 29.↵
    1. Farrell JA,
    2. Smith SA,
    3. Gordon-Lipkin EM, et al
    . High b-value q-space diffusion-weighted MRI of the human cervical spinal cord in vivo: feasibility and application to multiple sclerosis. Magn Reson Med 2008;59:1079–89 doi:10.1002/mrm.21563 pmid:18429023
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 42 (11)
American Journal of Neuroradiology
Vol. 42, Issue 11
1 Nov 2021
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Filtered Diffusion-Weighted MRI of the Human Cervical Spinal Cord: Feasibility and Application to Traumatic Spinal Cord Injury
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
S.A. Murphy, R. Furger, S.N. Kurpad, V.E. Arpinar, A. Nencka, K. Koch, M.D. Budde
Filtered Diffusion-Weighted MRI of the Human Cervical Spinal Cord: Feasibility and Application to Traumatic Spinal Cord Injury
American Journal of Neuroradiology Nov 2021, 42 (11) 2101-2106; DOI: 10.3174/ajnr.A7295

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Filtered Diffusion-Weighted MRI of the Human Cervical Spinal Cord: Feasibility and Application to Traumatic Spinal Cord Injury
S.A. Murphy, R. Furger, S.N. Kurpad, V.E. Arpinar, A. Nencka, K. Koch, M.D. Budde
American Journal of Neuroradiology Nov 2021, 42 (11) 2101-2106; DOI: 10.3174/ajnr.A7295
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Contrast-enhanced ultrasound for assessing tissue perfusion and predicting functional recovery following acute traumatic spinal injury: translation from rat model to humans
  • Influence of preprocessing, distortion correction and cardiac triggering on the quality of diffusion MR images of spinal cord
  • Crossref (10)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Differential Trajectory of Diffusion and Perfusion Magnetic Resonance Imaging of Rat Spinal Cord Injury
    Briana P. Meyer, Seung-Yi Lee, Shekar N. Kurpad, Matthew D. Budde
    Journal of Neurotrauma 2023 40 9-10
  • Diffusion Imaging of the Spinal Cord
    Jason F. Talbott, Vinil Shah, Allen Q. Ye
    Radiologic Clinics of North America 2024 62 2
  • Influence of preprocessing, distortion correction and cardiac triggering on the quality of diffusion MR images of spinal cord
    Kurt G. Schilling, Anna J.E. Combes, Karthik Ramadass, Francois Rheault, Grace Sweeney, Logan Prock, Subramaniam Sriram, Julien Cohen-Adad, John C. Gore, Bennett A. Landman, Seth A. Smith, Kristin P. O'Grady
    Magnetic Resonance Imaging 2024 108
  • Perfusion imaging metrics after acute traumatic spinal cord injury are associated with injury severity in rats and humans
    Zin Z. Khaing, Jannik Leyendecker, Jennifer N. Harmon, Sananthan Sivakanthan, Lindsay N. Cates, Jeffrey E. Hyde, Melissa Krueger, Robb W. Glenny, Matthew Bruce, Christoph P. Hofstetter
    Science Translational Medicine 2024 16 765
  • Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury
    Rakib Uddin Ahmed, Daniel Medina‐Aguinaga, Shawns Adams, Chase A. Knibbe, Monique Morgan, Destiny Gibson, Joo‐won Kim, Mayur Sharma, Manpreet Chopra, Steven Davison, Leslie C. Sherwood, M.J. Negahdar, Robert Bert, Beatrice Ugiliweneza, Charles Hubscher, Matthew D. Budde, Junqian Xu, Maxwell Boakye
    Annals of Clinical and Translational Neurology 2023 10 9
  • Beurteilung traumatischer Rückenmarksverletzungen mit der gefilterten DWI
    Radiologie up2date 2023 23 02
  • Beurteilung traumatischer Rückenmarksverletzungen mit der gefilterten DWI
    Neuroradiologie Scan 2022 12 04
  • Cross-hemicord spinal fiber reorganization associates with cortical sensory and motor network expansion in the rat model of hemicontusion cervical spinal cord injury
    Jelena M. Mihailovic, Basavaraju G. Sanganahalli, Fahmeed Hyder, Jyothsna Chitturi, Stella Elkabes, Robert F. Heary, Sridhar S. Kannurpatti
    Neuroscience Letters 2024 820
  • Differentiation Between Parotid Adenolymphoma and Malignant Tumor Based on Multimodal Functional MRI of Radiomics and Intratumoral Vascular ITSS Classification
    Baoting Yu, Chencui Huang, Xiaofei Fan, Dongyao Liu, Yuting Zhang, Jun Ding
    Annals of Surgical Oncology 2025
  • Imaging of Cervical Spine Trauma
    Melissa Warstadt, Blair Winegar, Lubdha M. Shah
    Clinical Spine Surgery 2024 37 9

More in this TOC Section

  • Bern Score Validity for SIH
  • MP2RAGE 7T in MS Lesions of the Cervical Spine
  • Resisted Inspiration for CSF-Venous Fistula
Show more Spine

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire