MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment

H.J. Kim; H. Cho; M. Park; J.W. Kim; S.J. Ahn; C.H. Lyoo; S.H. Suh; Y.H. Ryu

doi:10.3174/ajnr.A7155

Research ArticleAdult Brain

Open Access

MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment

H.J. Kim, H. Cho, M. Park, J.W. Kim, S.J. Ahn, C.H. Lyoo, S.H. Suh and Y.H. Ryu

American Journal of Neuroradiology July 2021, 42 (7) 1231-1238; DOI: https://doi.org/10.3174/ajnr.A7155

H.J. Kim

aFrom the Department of Nuclear Medicine (H.J.K., Y.H.R.)

dDepartment of Nuclear Medicine (H.J.K.), Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, South Korea

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for H.J. Kim

H. Cho

bNeurology (H.C., C.H.L.)

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for H. Cho

M. Park

cRadiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for M. Park

J.W. Kim

cRadiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for J.W. Kim

S.J. Ahn

cRadiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for S.J. Ahn

C.H. Lyoo

bNeurology (H.C., C.H.L.)

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for C.H. Lyoo

S.H. Suh

cRadiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for S.H. Suh

Y.H. Ryu

aFrom the Department of Nuclear Medicine (H.J.K., Y.H.R.)

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Y.H. Ryu

Article
Figures & Data
Supplemental
Info & Metrics
Responses
References
PDF

Article Information

vol. 42 no. 7 1231-1238

DOI

https://doi.org/10.3174/ajnr.A7155

PubMed

33985952

Published By

American Journal of Neuroradiology

Print ISSN

0195-6108

Online ISSN

1936-959X

History

Received June 18, 2020
Accepted after revision January 21, 2021
Published online July 13, 2021.

Author Information

H.J. Kima,d,
H. Chob,
M. Parkc,
J.W. Kimc,
S.J. Ahnc,
C.H. Lyoob,
S.H. Suhc and
Y.H. Ryua

^aFrom the Department of Nuclear Medicine (H.J.K., Y.H.R.)
^bNeurology (H.C., C.H.L.)
^cRadiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
^dDepartment of Nuclear Medicine (H.J.K.), Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, South Korea

Please address correspondence to Mina Park, MD, Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Eonjuro 211, Gangnam-gu, Seoul, South Korea; e-mail: to.minapark{at}yuhs.ac

View Full Text

Funding

National Research Foundation of Korea
Basic Science Research Program 2017R1D1A1B03034388; 2020R1C1C1005724
Yonsei University College of Medicine
Faculty research grant

Altmetrics

Cited By...

24 Citations
28 Citations
Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

Blood–Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights

Paulien H. M. Voorter, Maud van Dinther, Willemijn J. Jansen, Alida A. Postma, Julie Staals, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Merel M. van der Thiel, Walter H. Backes

Journal of Magnetic Resonance Imaging 2024 59 2
Lighter sleep is associated with higher enlarged perivascular spaces burden in middle-aged and elderly individuals

Andrée-Ann Baril, Adlin A. Pinheiro, Jayandra J. Himali, Alexa Beiser, Erlan Sanchez, Matthew P. Pase, Sudha Seshadri, Serkalem Demissie, Jose R. Romero

Sleep Medicine 2022 100
Enlarged Perivascular Spaces and Age-Related Clinical Diseases

Yuyuan Yang, Meng Wang, Moxin Luan, Xiaoqian Song, Yajuan Wang, Lulu Xu, Meixiang Zhong, Xueping Zheng

Clinical Interventions in Aging 2023 Volume 18
Effects of sleep on brain perivascular space in a cognitively healthy population

Nien-Chu Shih, Giuseppe Barisano, Karen D. Lincoln, Wendy J. Mack, Farshid Sepehrband, Jeiran Choupan

Sleep Medicine 2023 111
Enlarged Perivascular Spaces Are Negatively Associated With Montreal Cognitive Assessment Scores in Older Adults

Timothy J. Libecap, Valentinos Zachariou, Christopher E. Bauer, Donna M. Wilcock, Gregory A. Jicha, Flavius D. Raslau, Brian T. Gold

Frontiers in Neurology 2022 13
Enlarged Perivascular Spaces in Relation to Cumulative Blood Pressure Exposure and Cognitive Impairment

Huijing Shi, Liufu Cui, Ying Hui, Shouling Wu, Xiaoshuai Li, Rong Shu, Haicheng Song, Jierui Wang, Ping Yu, Shuohua Chen, Jing Li, Ling Yang, Zhenchang Wang, Qing Yang, Yuxia Gao

Hypertension 2023 80 10
Fluid dynamics in aging-related dementias

Thierno M. Bah, Dominic A. Siler, Aseel H. Ibrahim, Justin S. Cetas, Nabil J. Alkayed

Neurobiology of Disease 2023 177
Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET

Liangdong Zhou, Thanh D. Nguyen, Gloria C. Chiang, Xiuyuan H. Wang, Ke Xi, Tsung‐Wei Hu, Emily B. Tanzi, Tracy A. Butler, Mony J. de Leon, Yi Li

Alzheimer's & Dementia 2024 20 3
Combined Score of Perivascular Space Dilatation and White Matter Hyperintensities in Patients with Normal Cognition, Mild Cognitive Impairment, and Dementia

Nauris Zdanovskis, Ardis Platkājis, Andrejs Kostiks, Kristīne Šneidere, Ainārs Stepens, Roberts Naglis, Guntis Karelis

Medicina 2022 58 7
Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study

Oluchi Ekenze, Adlin Pinheiro, Serkalem Demissie, Andreas Charidimou, Alexa S. Beiser, Ramachandran S. Vasan, Emelia J. Benjamin, Charles DeCarli, Sudha Seshadri, Jose R. Romero

Neurobiology of Aging 2023 127
Association between enlarged perivascular spaces and cerebrospinal fluid aquaporin-4 and tau levels: report from a memory clinic

Luca Sacchi, Marina Arcaro, Tiziana Carandini, Anna Margherita Pietroboni, Giorgio Giulio Fumagalli, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Caterina Visconte, Manuela Pintus, Giorgio Conte, Valeria Elisa Contarino, Elio Scarpini, Fabio Triulzi, Daniela Galimberti, Andrea Arighi

Frontiers in Aging Neuroscience 2023 15
Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia

Arunima Kapoor, Aimée Gaubert, Belinda Yew, Jung Yun Jang, Shubir Dutt, Yanrong Li, John Paul M. Alitin, Amy Nguyen, Jean K. Ho, Anna E. Blanken, Isabel J. Sible, Anisa Marshall, Fatemah Shenasa, Kathleen E. Rodgers, Alessandra C. Martini, Elizabeth Head, Daniel A. Nation

Neurobiology of Aging 2023 128
Imaging features of small vessel disease in cerebral amyloid angiopathy among patients with Alzheimer’s disease

Nandakumar Nagaraja, Steven DeKosky, Ranjan Duara, Lan Kong, Wei-en Wang, David Vaillancourt, Mehmet Albayram

NeuroImage: Clinical 2023 38
A “glympse” into neurodegeneration: Diffusion MRI and cerebrospinal fluid aquaporin‐4 for the assessment of glymphatic system in Alzheimer's disease and other dementias

Luca Sacchi, Federico D'Agata, Corrado Campisi, Marina Arcaro, Tiziana Carandini, Balázs Örzsik, Vera Pacoova Dal Maschio, Chiara Fenoglio, Anna Margherita Pietroboni, Laura Ghezzi, Maria Serpente, Manuela Pintus, Giorgio Conte, Fabio Triulzi, Leonardo Lopiano, Daniela Galimberti, Mara Cercignani, Marco Bozzali, Andrea Arighi

Human Brain Mapping 2024 45 12
An Enlarged Perivascular Space: Clinical Relevance and the Role of Imaging in Aging and Neurologic Disorders

Younghee Yim, Won-Jin Moon

Journal of the Korean Society of Radiology 2022 83 3
Perivascular Space Predicts Brain Hypometabolism of Individuals with Underlying Amyloid Pathology

Xiaolei Shi, Nan Zhou, Bin Sun, Yongshun Wu, Yachun Hu, Yuping Ning

Journal of Alzheimer's Disease 2022 90 3
Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease

Daniele Botta, Ioana Hutuca, Elyas El Ghoul, Lukas Sveikata, Frédéric Assal, Karl-Olof Lövblad, Felix T. Kurz

Journal of Neuroradiology 2025 52 3
Quantitative assessment of enlarged perivascular spaces via deep-learning in community-based older adults reveals independent associations with vascular neuropathologies, vascular risk factors and cognition

Carles Javierre-Petit, Marinos Kontzialis, Sue E Leurgans, David A Bennett, Julie A Schneider, Konstantinos Arfanakis

Brain Communications 2024 6 4
Lifetime history of head injury is associated with reduced perivascular space number in acute mild traumatic brain injury

Kiersten J Garcia, Grace Brolly, Daniel Ng, Maria Bederson, Pedro Martinez, Mark D Whiting

Brain Communications 2024 6 5
Neuroinflammation modifies the relationship between stress and perivascular spaces in an elderly population with different levels of cognitive impairment

Francesca Sibilia, Nasim Sheikh-Bahaei, Wendy J. Mack, Giuseppe Barisano, Jeiran Choupan

Frontiers in Cellular Neuroscience 2024 18
Perivascular Spaces: Neuroimaging, Microanatomy, Homeostasis, and Pathophysiologic Mechanisms of Disease

E. Zamora, C. Zamora

Neurographics 2024 14 2
Validation of the Boston Criteria Version 2.0 for Cerebral Amyloid Angiopathy in Patients Presenting With Intracerebral Hemorrhage

Margaret H. Downes, Roshini Kalagara, Christina P. Rossitto, Vikram Vasan, Devarshi Vasa, Susmita Chennareddy, Daniel R. Lefton, Sema Yildiz, Melissa Umphlett, Carolyn Brockington, Christopher P. Kellner

Neurology 2025 104 7
Association between Perivascular Spaces Burden and Future Stroke Risk in Ischemic Stroke and Transient Ischemic Attack: A Systematic Review and Meta-Analysis

Hanhan Lei, Xiaomin Wu, Gareth Ambler, David Werring, Shuangfang Fang, Huiyin Lin, Huapin Huang, Nan Liu, Houwei Du

European Neurology 2024 87 3
Association between apolipoprotein E gene polymorphism and early MR findings in individuals with acute intracerebral hemorrhage: A retrospective cohort analysis

Zhenjie Yang, Qiuxia Xiong, Rui He, Chuyue Wu, Yu Huang, Qian Li, Xinghua Liu

Journal of Stroke and Cerebrovascular Diseases 2025 34 1
Association of MRI-Visible Perivascular Spaces and Incident Depression in the Framingham Heart Study

Sara Medved, Adlin Pinheiro, Pedram Parva, Andreas Charidimou, Jayandra J. Himali, Charles S. Decarli, Alexa S. Beiser, Sudha Seshadri, Serkalem Demissie, Jose Rafael Romero

Neurology Open Access 2025 1 3
Brain glymphatic fluid mapping in Alzheimer’s disease: a human MRI and PET study

Liangdong Zhou, Thanh D Nguyen, Gloria C Chiang, Samantha A Keil, Xiuyuan Hugh Wang, Tsung-Wei Hu, Haoyu Lan, Ke Xi, Ana Paula Costa, Emily B Tanzi, Lidia Glodzik, Jarek Wegiel, Tracy Butler, Mony J de Leon, Yi Li

Brain Communications 2025 7 3
Clinical Relevance of Enlarged Perivascular Spaces in Neurodegenerative Disease

Yu-Ri Je, Hong-Gi Ham, Yu-Hyun Park, Tae-Yun Kim, Min-su Go, Hye-In Lee, Da Eun Kim, Na-Yeon Jung, Myung Jun Lee, Sang-Won Seo, Eun-Joo Kim

Journal of the Korean Neurological Association 2023 41 4
Enlarged perivascular spaces correlate with blood-brain barrier leakage and cognitive impairment in Alzheimer's disease

Chen Wen, Jing-Huan Gan, Shuai Liu, Hao Lu, Li-Chen Wang, Hao Wu, Zhi-Hong Shi, Yong Ji

Journal of Alzheimer’s Disease 2025 104 2

PreviousNext

In this issue

American Journal of Neuroradiology

Vol. 42, Issue 7

1 Jul 2021

Table of Contents
Index by author
Complete Issue (PDF)

Download PDF

Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment

Message Subject (Your Name) has sent you a message from American Journal of Neuroradiology

Message Body (Your Name) thought you would like to see the American Journal of Neuroradiology web site.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Cite this article

H.J. Kim, H. Cho, M. Park, J.W. Kim, S.J. Ahn, C.H. Lyoo, S.H. Suh, Y.H. Ryu

MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment

American Journal of Neuroradiology Jul 2021, 42 (7) 1231-1238; DOI: 10.3174/ajnr.A7155

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

0 Responses

Respond to this article

Bookmark this article

User Name *

Password *

Remember my user name & password.

MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment

H.J. Kim, H. Cho, M. Park, J.W. Kim, S.J. Ahn, C.H. Lyoo, S.H. Suh, Y.H. Ryu

American Journal of Neuroradiology Jul 2021, 42 (7) 1231-1238; DOI: 10.3174/ajnr.A7155

Share This Article:

Tweet Widget
Facebook Like
Google Plus One

Purchase

Jump to section

Article
Figures & Data
Supplemental
Info & Metrics
Responses
References
PDF

PubMed
Google Scholar

Cited By...

The association between enlarged perivascular spaces and muscle sympathetic nerve activity in normotensive and hypertensive humans
Perivascular spaces in Alzheimers disease are associated with inflammatory, stress-related, and hypertension biomarkers

Crossref (28)
Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

Blood–Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights

Paulien H. M. Voorter, Maud van Dinther, Willemijn J. Jansen, Alida A. Postma, Julie Staals, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Merel M. van der Thiel, Walter H. Backes

Journal of Magnetic Resonance Imaging 2024 59 2
Lighter sleep is associated with higher enlarged perivascular spaces burden in middle-aged and elderly individuals

Andrée-Ann Baril, Adlin A. Pinheiro, Jayandra J. Himali, Alexa Beiser, Erlan Sanchez, Matthew P. Pase, Sudha Seshadri, Serkalem Demissie, Jose R. Romero

Sleep Medicine 2022 100
Enlarged Perivascular Spaces and Age-Related Clinical Diseases

Yuyuan Yang, Meng Wang, Moxin Luan, Xiaoqian Song, Yajuan Wang, Lulu Xu, Meixiang Zhong, Xueping Zheng

Clinical Interventions in Aging 2023 Volume 18
Effects of sleep on brain perivascular space in a cognitively healthy population

Nien-Chu Shih, Giuseppe Barisano, Karen D. Lincoln, Wendy J. Mack, Farshid Sepehrband, Jeiran Choupan

Sleep Medicine 2023 111
Enlarged Perivascular Spaces Are Negatively Associated With Montreal Cognitive Assessment Scores in Older Adults

Timothy J. Libecap, Valentinos Zachariou, Christopher E. Bauer, Donna M. Wilcock, Gregory A. Jicha, Flavius D. Raslau, Brian T. Gold

Frontiers in Neurology 2022 13
Enlarged Perivascular Spaces in Relation to Cumulative Blood Pressure Exposure and Cognitive Impairment

Huijing Shi, Liufu Cui, Ying Hui, Shouling Wu, Xiaoshuai Li, Rong Shu, Haicheng Song, Jierui Wang, Ping Yu, Shuohua Chen, Jing Li, Ling Yang, Zhenchang Wang, Qing Yang, Yuxia Gao

Hypertension 2023 80 10
Fluid dynamics in aging-related dementias

Thierno M. Bah, Dominic A. Siler, Aseel H. Ibrahim, Justin S. Cetas, Nabil J. Alkayed

Neurobiology of Disease 2023 177
Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET

Liangdong Zhou, Thanh D. Nguyen, Gloria C. Chiang, Xiuyuan H. Wang, Ke Xi, Tsung‐Wei Hu, Emily B. Tanzi, Tracy A. Butler, Mony J. de Leon, Yi Li

Alzheimer's & Dementia 2024 20 3
Combined Score of Perivascular Space Dilatation and White Matter Hyperintensities in Patients with Normal Cognition, Mild Cognitive Impairment, and Dementia

Nauris Zdanovskis, Ardis Platkājis, Andrejs Kostiks, Kristīne Šneidere, Ainārs Stepens, Roberts Naglis, Guntis Karelis

Medicina 2022 58 7
Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study

Oluchi Ekenze, Adlin Pinheiro, Serkalem Demissie, Andreas Charidimou, Alexa S. Beiser, Ramachandran S. Vasan, Emelia J. Benjamin, Charles DeCarli, Sudha Seshadri, Jose R. Romero

Neurobiology of Aging 2023 127

Main menu

User menu

Search

American Journal of Neuroradiology

MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment

Article Information

Author Information

Funding

National Research Foundation of Korea

Yonsei University College of Medicine

Altmetrics

Cited By...

In this issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Similar Articles

Indexed Content

Cases

Special Collections

Resources

Multimedia

About Us

American Society of Neuroradiology