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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Review ArticleAdult Brain
Open Access

Radiologic Evaluation Criteria for Chronic Subdural Hematomas: Recommendations for Clinical Trials

R. McDonough, M. Bechstein, J. Fiehler, U. Zanolini, H. Rai, A. Siddiqui, E. Shotar, A. Rouchaud, K. Kallmes, M. Goyal and S. Gellissen
American Journal of Neuroradiology November 2022, 43 (11) 1550-1558; DOI: https://doi.org/10.3174/ajnr.A7503
R. McDonough
aFrom the Department of Diagnostic and Interventional Neuroradiolog (R.M., M.B., J.F., U.Z., S.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
bResearch Committee (R.M., M.B., J.F., U.Z., E.S., S.G.), European Society of Minimally Invasive Neurological Therapy, Zürich, Switzerland
gDepartment of Radiology (R.M., M.G.), University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
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M. Bechstein
aFrom the Department of Diagnostic and Interventional Neuroradiolog (R.M., M.B., J.F., U.Z., S.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
bResearch Committee (R.M., M.B., J.F., U.Z., E.S., S.G.), European Society of Minimally Invasive Neurological Therapy, Zürich, Switzerland
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J. Fiehler
aFrom the Department of Diagnostic and Interventional Neuroradiolog (R.M., M.B., J.F., U.Z., S.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
bResearch Committee (R.M., M.B., J.F., U.Z., E.S., S.G.), European Society of Minimally Invasive Neurological Therapy, Zürich, Switzerland
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U. Zanolini
aFrom the Department of Diagnostic and Interventional Neuroradiolog (R.M., M.B., J.F., U.Z., S.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
bResearch Committee (R.M., M.B., J.F., U.Z., E.S., S.G.), European Society of Minimally Invasive Neurological Therapy, Zürich, Switzerland
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H. Rai
cDepartment of Neurosurgery (H.R., A.S.), University at Buffalo, Buffalo, New York
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A. Siddiqui
cDepartment of Neurosurgery (H.R., A.S.), University at Buffalo, Buffalo, New York
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E. Shotar
bResearch Committee (R.M., M.B., J.F., U.Z., E.S., S.G.), European Society of Minimally Invasive Neurological Therapy, Zürich, Switzerland
dNeuroradiology Department (E.S.), Pitié-Salpêtrière Hospital, Paris, France
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A. Rouchaud
eDepartment of Neuroradiology (A.R.), Dupuytren University Hospital of Limoges, Limoges Cedex, France
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K. Kallmes
fNested Knowledge, Inc (K.K.), St. Paul, Minnesota
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M. Goyal
gDepartment of Radiology (R.M., M.G.), University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
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S. Gellissen
aFrom the Department of Diagnostic and Interventional Neuroradiolog (R.M., M.B., J.F., U.Z., S.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
bResearch Committee (R.M., M.B., J.F., U.Z., E.S., S.G.), European Society of Minimally Invasive Neurological Therapy, Zürich, Switzerland
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    Fig 1.

    Sunburst diagram of data elements in the NK nest for this study. Clicking on each data element outputs a frequency of the tag associated with it, as well as frequently co-occurring tags. See https://nested-knowledge.com/nest/qualitative/461 for an interactive version of this figure.

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    Fig 2.

    The effect of SDH morphology on volume calculation using the ABC/2. The formula is derived by assuming a crescent shape (the difference between a large ellipsoid and a small ellipsoid, both of which are cut in half). A and B, L = length; W = width, difference between ellipsoids = Wa, Wb; C, Thickness (not shown) (L and C are the same for both ellipsoids). The formula thus reduces to volume of crescent-shaped cSDH = (4/3 π LWaC – 4/3 π LWbC) / 2 = (LWaC – LWbC)/ 2 = LWC/ 2 (= ABC/2). A, The assumed crescent shape allows accurate calculation due to the way the ABC/2 formula is derived (right panel). B, When the SDH is irregular, however, the ABC/2 loses accuracy and can lead to overestimation of the true volume. C, cSDH maximum width perpendicular to the maximum length marked in specific patients with unevenly shaped hematomas. Patient 1: width of the subdural hematoma measured on a section close to vertex (W) is greater than it actually is. Patient 2: inhomogeneous convex- and concave-shaped hematomas. Maximum width (W2) measurement is diagonal and not accurate. W1 would be more accurate in this case. Patient 3: maximum width measured perpendicular to length but slices hematoma diagonally.

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    Fig 3.

    Proposed MLS measurement as the mean of maximum at the level and location of the foramen of Monro (MLS-M1), the maximum displacement of the septum pellucidum relative to the midline (MLS-M2), and the maximum MLS of the septum pellucidum at the level of the highest point of the septum on coronal slices (MLS-C3). Overall MLS is determined as the mean of these 3 measurements (or 2 in cases in which coronal reconstructions are missing). MLS-M indicates axial MLS perpendicular to the midline; MLS-C, coronal MLS perpendicular to the midline.

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    Table 1.

    Expert suggestions for radiologic measurements of cSDH for volume, width, MLS, and reporting

    cSDH Volume/WidthMLSReporting
    • Preferably use computer-assisted volumetric analysis

    • In case width is measured, report detailed methodology

    • Measured perpendicular to the midline joining the most anterior and posterior visible points on the falx

    • Measurements should be conducted on axial and coronal slices

    • On axial slices measured at the level and location of the foramen of Monro and as the maximum displacement of the septum pellucidum relative to the midline

    • On coronal slices as the maximum MLS of the septum pellucidum at the level of the highest point of the septum

    • Overall MLS should then be determined as mean of these 3 (or 2 in case no coronal slices are available) measurements

    • cSDH width should always be evaluated and reported in context with cSDH volume measurements, MLS, and clinical information

    • MLS should always be assessed together with other parameters such as clinical information and cSDH volume

    • Detailed description of the used algorithms when reporting cSDH width, volume, MLS, or other quantitative radiologic measures should be provided

    • View popup
    Table 2.

    Advantages and disadvantages of singular and combinations of radiographic measurements to evaluate cSDH progression

    AdvantageDisadvantage
    WidthSimple, practical, good external applicability, sensitivity easy to adjust (2 vs 5 mm, and so forth)Too dependent on measurement technique and location, sensitivity might be low
    VolumeIntuitively the right choice, presumably most accurateLabor intensive, unlikely to be used in day-to-day practice
    Volume + widthRaises the bar for specificityMore challenging to interpret, 2 thresholds to define
    Less sensitive
    Volume + width + MLSRaises the bar for specificity even furtherEven more challenging to interpret, definition issues, 2 df (>2 mm and > 2 mm and > 20 mL)
    Low sensitivity
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American Journal of Neuroradiology: 43 (11)
American Journal of Neuroradiology
Vol. 43, Issue 11
1 Nov 2022
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Cite this article
R. McDonough, M. Bechstein, J. Fiehler, U. Zanolini, H. Rai, A. Siddiqui, E. Shotar, A. Rouchaud, K. Kallmes, M. Goyal, S. Gellissen
Radiologic Evaluation Criteria for Chronic Subdural Hematomas: Recommendations for Clinical Trials
American Journal of Neuroradiology Nov 2022, 43 (11) 1550-1558; DOI: 10.3174/ajnr.A7503

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Radiologic Evaluation Criteria for Chronic Subdural Hematomas: Recommendations for Clinical Trials
R. McDonough, M. Bechstein, J. Fiehler, U. Zanolini, H. Rai, A. Siddiqui, E. Shotar, A. Rouchaud, K. Kallmes, M. Goyal, S. Gellissen
American Journal of Neuroradiology Nov 2022, 43 (11) 1550-1558; DOI: 10.3174/ajnr.A7503
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