Article Figures & Data
Figures
- FIG 1.
Lesions with DWI reversal assessed by MR imaging DWI/ADC, DWI, ADC, and MRA images show a subtotal reversal of the left frontal ischemic lesion 24 hours after MT for M1 occlusion. The ADC values (mean, maximum, minimum) with reversal are measured in the ROIs (white circled area with a continuous line) in the pretreatment MR imaging, and each parameter is averaged. The ADC values (mean, maximum, minimum) without reversal are measured in the ROI (white circled area with a dotted line) at the pretreatment MR imaging. The ADC values of lesions with DWI reversal (mean, maximum, minimum) are 525 × 10−6 mm2/s, 748 × 10−6 mm2/s, and 368 × 10−6 mm2/s, respectively. The ADC values of lesions without DWI reversal (mean, maximum, minimum) are 434 × 10−6 mm2/s, 560 × 10−6 mm2/s, and 311 × 10−6 mm2/s, respectively.
- FIG 2.
Flowchart of the study process.
- FIG 3.
The ADC values of the initial DWI lesion (mean, maximum, minimum) according to the presence or absence of DWI reversal areas. Eighty-three percent (35 of 42) of patients with DWI reversal areas had mean ADC values of ≥520 × 10−6 mm2/s, and 71% (54 of 76) of patients without DWI reversal areas had ADC values of <520 × 10−6 mm2/s. Seventy-four percent (31 of 42) of patients with DWI reversal areas had maximum ADC values of ≥700 × 10−6 mm2/s, and 66% (50 of 76) of patients without DWI reversal areas had ADC values of <700 × 10−6 mm2/s. Seventy-four percent (31 of 42) of patients with DWI reversal areas had minimum ADC values of ≥400 × 10−6 mm2/s, and 68% (52 of 76) of patients without DWI reversal areas had ADC values of <400 × 10−6 mm2/s. The ADC values (mean, maximum, minimum) were significantly higher in patients with DWI reversal areas than in those without DWI reversal areas (P < .0001). The receiver operating characteristic curve for the collected data of this study (mean, maximum, minimum) shows that the ADC reflects areas that could be reversed by reperfusion therapy. The areas under the curves (mean, maximum, minimum) are 0.82, 0.75, and 0.78, respectively. The optimal mean, maximum, and minimum ADC thresholds for discriminating reversibility from DWI lesions are 520 × 10−6 mm2/s, 700 × 10−6 mm2/s, and 400 × 10−6 mm2/s with sensitivities of 71%, 68%, and 68% and specificities of 83%, 74%, and 74%, respectively.
- Fig 4.
mRS score 3 months after treatment. The rate of functional independence (mRS = 0–2) was significantly higher in patients with DWI reversal than in patients without DWI reversal (P = .011).
