Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticleHead and Neck Imaging
Open Access

Glymphatic System in Ocular Diseases: Evaluation of MRI Findings

P. Manava, C. Eckrich, F. Luciani, J. Schmidbauer, M.M. Lell and K. Detmar
American Journal of Neuroradiology July 2022, 43 (7) 1012-1017; DOI: https://doi.org/10.3174/ajnr.A7552
P. Manava
aFrom the Departments of Radiology and Nuclear Medicine (P.M., C.E., M.M.L., K.D.)
cInstitute of Radiology (P.M., M.M.L.), Friedrich-Alexander University, University of Erlangen-Nuremberg, Erlangen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Manava
C. Eckrich
aFrom the Departments of Radiology and Nuclear Medicine (P.M., C.E., M.M.L., K.D.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Eckrich
F. Luciani
bOphthalmology and Visual Science (F.L., J.S.), Klinikum Nuernberg, Paracelsus Medical University, Nuernberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Schmidbauer
bOphthalmology and Visual Science (F.L., J.S.), Klinikum Nuernberg, Paracelsus Medical University, Nuernberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.M. Lell
aFrom the Departments of Radiology and Nuclear Medicine (P.M., C.E., M.M.L., K.D.)
cInstitute of Radiology (P.M., M.M.L.), Friedrich-Alexander University, University of Erlangen-Nuremberg, Erlangen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. Detmar
aFrom the Departments of Radiology and Nuclear Medicine (P.M., C.E., M.M.L., K.D.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Brinker T,
    2. Stopa E,
    3. Morrison J, et al
    . A new look at cerebrospinal fluid circulation. Fluids Barriers CNS 2014;11:10 doi:10.1186/2045-8118-11-10 pmid:24817998
    CrossRefPubMed
  2. 2.↵
    1. Deike-Hofmann K,
    2. Reuter J,
    3. Haase R, et al
    . Glymphatic pathway of gadolinium-based contrast agents through the brain: overlooked and misinterpreted. Invest Radiol 2018;54:229–37 doi:10.1097/RLI.0000000000000533 pmid:24817998
    CrossRefPubMed
  3. 3.↵
    1. Wostyn P,
    2. De Groot V,
    3. Van Dam D, et al
    . The glymphatic hypothesis of glaucoma: a unifying concept incorporating vascular, biomechanical, and biochemical aspects of the disease. Biomed Res Int 2017;2017:5123148 doi:10.1155/2017/5123148 pmid:28948167
    CrossRefPubMed
  4. 4.↵
    1. Galmiche C,
    2. Moal B,
    3. Marnat G, et al
    . Delayed gadolinium leakage in ocular structures: a potential marker for age- and vascular risk factor-related small vessel disease? Invest Radiol 2021;56:425–32 doi:10.1097/RLI.0000000000000757 pmid:33481460
    CrossRefPubMed
  5. 5.↵
    1. Förster A,
    2. Böhme J,
    3. Groden C, et al
    . Gadolinium leakage in ocular structures in optic neuritis. J Clin Neurosci 2019;68:268–70 doi:10.1016/j.jocn.2019.05.050 pmid:31204221
    CrossRefPubMed
  6. 6.↵
    1. Herrera DA,
    2. Franco S,
    3. Bustamante S, et al
    . Contrast-enhanced T2-FLAIR MR imaging in patients with uveitis. Int Ophthalmol 2017;37:507–12 doi:10.1007/s10792-016-0289-1 pmid:27405314
    CrossRefPubMed
  7. 7.↵
    1. Deike-Hofmann K,
    2. von Lampe P,
    3. Schlemmer HP, et al
    . The anterior eye chamber: entry of the natural excretion pathway of gadolinium contrast agents? Eur Radiol 2020;30:4633–40 doi:10.1007/s00330-020-06762-4 pmid:32179994
    CrossRefPubMed
  8. 8.↵
    1. Taoka T,
    2. Naganawa S
    . Gadolinium-based contrast media, cerebrospinal fluid and the glymphatic system: possible mechanisms for the deposition of gadolinium in the brain. Magn Reson Med Sci 2018;17:111–19 doi:10.2463/mrms.rev.2017-0116 pmid:29367513
    CrossRefPubMed
  9. 9.↵
    1. Pardridge WM
    . CSF, blood-brain barrier, and brain drug delivery. Expert Opin Drug Deliv 2016;13:963–75 doi:10.1517/17425247.2016.1171315 pmid:27020469
    CrossRefPubMed
  10. 10.↵
    1. Wostyn P,
    2. Van Dam D,
    3. Audenaert K, et al
    . A new glaucoma hypothesis: a role of glymphatic system dysfunction. Fluids Barriers CNS 2015;12:16 doi:10.1186/s12987-015-0012-z pmid:26118970
    CrossRefPubMed
  11. 11.↵
    1. Naganawa S,
    2. Kawai H,
    3. Taoka T, et al
    . Heavily T2-weighted 3D-FLAIR improves the detection of cochlear lymph fluid signal abnormalities in patients with sudden sensorineural hearing loss. Magn Reson Med Sci 2016;15:203–11 doi:10.2463/mrms.mp.2015-0065 pmid:26597430
    CrossRefPubMed
  12. 12.↵
    1. Hitomi E,
    2. Simpkins AN,
    3. Luby M, et al
    . Blood-ocular barrier disruption in patients with acute stroke. Neurology 2018;90:e915–23 doi:10.1212/WNL.0000000000005123 pmid:29438039
    Abstract/FREE Full Text
  13. 13.↵
    1. Jones O,
    2. Cutsforth-Gregory J,
    3. Chen J, et al
    . Idiopathic intracranial hypertension is associated with a higher burden of visible cerebral perivascular spaces: the glymphatic connection. AJNR Am J Neuroradiol 2021;42:2160–64 doi:10.3174/ajnr.A7326 pmid:34824096
    Abstract/FREE Full Text
  14. 14.↵
    1. Shinohara RT,
    2. Sweeney EM,
    3. Goldsmith J, et al
    . Statistical normalization techniques for magnetic resonance imaging. Neuroimage Clin 2014;6:9–19 doi:10.1016/j.nicl.2014.08.008 pmid:25379412
    CrossRefPubMed
  15. 15.↵
    1. Bill A
    . Capillary permeability to and extravascular dynamics of myoglobin, albumin and gammaglobulin in the uvea. Acta Physiol Scand 1968;73:204–19 doi:10.1111/j.1748-1716.1968.tb04097.x pmid:4175033
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Jacobsen HH,
    2. Ringstad G,
    3. Jørstad ØK, et al
    . The human visual pathway communicates directly with the subarachnoid space. Invest Ophthalmol Vis Sci 2019;60:2773– 80 doi:10.1167/iovs.19-26997 pmid:31247084
    CrossRefPubMed
  17. 17.↵
    1. Jacobsen HH,
    2. Sandell T,
    3. Jørstad ØK, et al
    . In vivo evidence for impaired glymphatic function in the visual pathway of patients with normal pressure hydrocephalus. Invest Ophthalmol Vis Sci 2020;61:24 doi:10.1167/iovs.61.13.24 pmid:33201186
    CrossRefPubMed
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Glymphatic System in Ocular Diseases: Evaluation of MRI Findings
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
P. Manava, C. Eckrich, F. Luciani, J. Schmidbauer, M.M. Lell, K. Detmar
Glymphatic System in Ocular Diseases: Evaluation of MRI Findings
American Journal of Neuroradiology Jul 2022, 43 (7) 1012-1017; DOI: 10.3174/ajnr.A7552

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Glymphatic System MRI in Ocular Diseases
P. Manava, C. Eckrich, F. Luciani, J. Schmidbauer, M.M. Lell, K. Detmar
American Journal of Neuroradiology Jul 2022, 43 (7) 1012-1017; DOI: 10.3174/ajnr.A7552
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Delayed Gadolinium Leakage in Ocular Structures on Brain MR Imaging: Prevalence and Associated Factors
  • Crossref (7)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood
    Matthias J. P. van Osch, Anders Wåhlin, Paul Scheyhing, Ingrid Mossige, Lydiane Hirschler, Anders Eklund, Klara Mogensen, Ryszard Gomolka, Alexander Radbruch, Sara Qvarlander, Andreas Decker, Maiken Nedergaard, Yuki Mori, Per Kristian Eide, Katerina Deike, Geir Ringstad
    NMR in Biomedicine 2024 37 9
  • Glymphatic System Dysfunction Underlying Schizophrenia Is Associated With Cognitive Impairment
    Ye Tu, Yan Fang, Guohui Li, Fei Xiong, Feng Gao
    Schizophrenia Bulletin 2024 50 5
  • Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging
    Shinji Naganawa, Rintaro Ito, Mariko Kawamura, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone
    Magnetic Resonance in Medical Sciences 2025 24 2
  • Delayed Gadolinium Leakage in Ocular Structures on Brain MR Imaging: Prevalence and Associated Factors
    Richard Olatunji, Timothy Reynold Lim, Blair Jones, Monica Tafur, Shobhit Mathur, Amy W. Lin, Aditya Bharatha, Suradech Suthiphosuwan
    American Journal of Neuroradiology 2024 45 1
  • Gadolinium-Anreicherung bei verschiedenen Augenerkrankungen in der MRT
    Neuroradiologie Scan 2023 13 01
  • Gadolinium-Anreicherung bei verschiedenen Augenerkrankungen in der MRT
    Radiologie up2date 2023 23 04
  • Gadolinium-Based Imaging and the Study of Neurofluid Dynamics
    Geir Ringstad, Per Kristian Eide, Shinji Naganawa, Nivedita Agarwal
    Neuroimaging Clinics of North America 2025 35 2

More in this TOC Section

  • Imaging Hyrtl Fissure: Congenital CSF Otorrhea
  • Vestibular Schwannoma: PostGad Signal & Hearing Loss
  • CT facial recess and hard cochlear implantation
Show more Head and Neck Imaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire