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Research ArticleAdult Brain
Open Access

Unsupervised Deep Learning for Stroke Lesion Segmentation on Follow-up CT Based on Generative Adversarial Networks

H. van Voorst, P.R. Konduri, L.M. van Poppel, W. van der Steen, P.M. van der Sluijs, E.M.H. Slot, B.J. Emmer, W.H. van Zwam, Y.B.W.E.M. Roos, C.B.L.M. Majoie, G. Zaharchuk, M.W.A. Caan and H.A. Marquering on behalf of the CONTRAST Consortium Collaborators
American Journal of Neuroradiology August 2022, 43 (8) 1107-1114; DOI: https://doi.org/10.3174/ajnr.A7582
H. van Voorst
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
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P.R. Konduri
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
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L.M. van Poppel
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
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  • ORCID record for L.M. van Poppel
W. van der Steen
dDepartments of Neurology (W.v.d.S., P.M.v.d.S.)
eRadiology and Nuclear Medicine (W.v.d.S., P.M.v.d.S.), Erasmus University Medical Center, Rotterdam, the Netherlands
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P.M. van der Sluijs
dDepartments of Neurology (W.v.d.S., P.M.v.d.S.)
eRadiology and Nuclear Medicine (W.v.d.S., P.M.v.d.S.), Erasmus University Medical Center, Rotterdam, the Netherlands
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E.M.H. Slot
fDepartment of Neurology and Neurosurgery (E.M.H.S.), University Medical Center Utrecht, Utrecht, the Netherlands
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B.J. Emmer
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
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W.H. van Zwam
gDepartment of Radiology and Nuclear Medicine (W.H.v.Z.), Maastricht University Medical Center, Maastricht, the Netherlands
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Y.B.W.E.M. Roos
cNeurology (Y.B.W.E.M.R.), Faculty of Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands
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C.B.L.M. Majoie
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
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G. Zaharchuk
hDepartment of Radiology (G.Z.), Stanford University, Stanford, California
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M.W.A. Caan
bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
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H.A. Marquering
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
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Article Information

vol. 43 no. 8 1107-1114
DOI 
https://doi.org/10.3174/ajnr.A7582
PubMed 
35902122

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received January 27, 2022
  • Accepted after revision June 2, 2022
  • Published online August 8, 2022.

Copyright & Usage 
© 2022 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. H. van Voorsta,b,
  2. P.R. Konduria,b,
  3. L.M. van Poppela,b,
  4. W. van der Steend,e,
  5. P.M. van der Sluijsd,e,
  6. E.M.H. Slotf,
  7. B.J. Emmera,
  8. W.H. van Zwamg,
  9. Y.B.W.E.M. Roosc,
  10. C.B.L.M. Majoiea,
  11. G. Zaharchukh,
  12. M.W.A. Caanb and
  13. H.A. Marqueringa,b on behalf of the CONTRAST Consortium Collaborators
  1. aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
  2. bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
  3. cNeurology (Y.B.W.E.M.R.), Faculty of Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands
  4. dDepartments of Neurology (W.v.d.S., P.M.v.d.S.)
  5. eRadiology and Nuclear Medicine (W.v.d.S., P.M.v.d.S.), Erasmus University Medical Center, Rotterdam, the Netherlands
  6. fDepartment of Neurology and Neurosurgery (E.M.H.S.), University Medical Center Utrecht, Utrecht, the Netherlands
  7. gDepartment of Radiology and Nuclear Medicine (W.H.v.Z.), Maastricht University Medical Center, Maastricht, the Netherlands
  8. hDepartment of Radiology (G.Z.), Stanford University, Stanford, California
    1. 1Erasmus MC University Medical Center, Rotterdam, the Netherlands
    2. 2Leiden University Medical Center, Leiden, the Netherlands
    3. 3Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands
    4. 4Cardiovascular Research Institute Maastricht (CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    5. 5University Medical Center Utrecht, Brain Center Rudolf Magnus, Utrecht, the Netherlands
    6. 6Catharina Hospital, Eindhoven, the Netherlands
    7. 7Haaglanden Medical Centre, the Hague, the Netherlands
    8. 8Rijnstate Hospital, Arnhem, the Netherlands
    9. 9St. Antonius Hospital, Nieuwegein, the Netherlands
    10. 10Radboud University Medical Center, Nijmegen, the Netherlands
    11. 11HagaZiekenhuis, the Hague, the Netherlands
    12. 12Isala, Zwolle, the Netherlands
    13. 13Amphia Hospital, Breda, the Netherlands
    14. 14Albert Schweitzer Hospital, Dordrecht, the Netherlands
    15. 15University Medical Center Groningen, Groningen, the Netherlands
    16. 16Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands
    17. 17University Hospital of Nancy, Nancy, France
    18. 18Foch Hospital, Suresnes, France
    19. 19Fondation Rothschild Hospital, Paris, France
    20. 20University Hospital of Bordeaux, Bordeaux, France
    21. 21Pitié-Salpêtrière University hospital, Paris, France
    22. 22John Radcliffe Hospital, Oxford, United Kingdom
    23. 23University of Washington, Seattle, Washington, United States
    24. 24Lygature, Utrecht, the Netherlands
    25. 25School for Mental Health and Sciences (Mhens, Maastricht University Medical Center, Maastricht, The Netherlands
    26. 26Texas Stroke Institute, Dallas-Fort Worth, Texas, United States of America
    27. 27Medisch Spectrum Twente, Enschede, The Netherlands
    28. 28TerGooi, Hilversum, The Netherlands
    1. Please address correspondence to Henk van Voorst, MD, Amsterdam UMC locatie AMC, Meibergdreef 9, 1105 AZ Amsterdam, Noord-Holland, the Netherlands, Department of Biomedical Engineering and Physics, Department of Radiology and Nuclear Medicine, Room L0147, 020 566 9111; e-mail: h.vanvoorst{at}amsterdamumc.nl
    View Full Text

    Funding

    • Hartstichting

      CVON2015-01: CONTRAST
    • Stryker

    • Dutch Ministry of Economic Affairs

      LSHM17016
    • Cerenovus

    • Brain Foundation Netherlands

      HA2015.01.06
    • Medtronic

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    H. van Voorst, P.R. Konduri, L.M. van Poppel, W. van der Steen, P.M. van der Sluijs, E.M.H. Slot, B.J. Emmer, W.H. van Zwam, Y.B.W.E.M. Roos, C.B.L.M. Majoie, G. Zaharchuk, M.W.A. Caan, H.A. Marquering
    Unsupervised Deep Learning for Stroke Lesion Segmentation on Follow-up CT Based on Generative Adversarial Networks
    American Journal of Neuroradiology Aug 2022, 43 (8) 1107-1114; DOI: 10.3174/ajnr.A7582

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    Unsupervised DL for Stroke Lesion Segmentation
    H. van Voorst, P.R. Konduri, L.M. van Poppel, W. van der Steen, P.M. van der Sluijs, E.M.H. Slot, B.J. Emmer, W.H. van Zwam, Y.B.W.E.M. Roos, C.B.L.M. Majoie, G. Zaharchuk, M.W.A. Caan, H.A. Marquering
    American Journal of Neuroradiology Aug 2022, 43 (8) 1107-1114; DOI: 10.3174/ajnr.A7582
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    • Endovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial
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