Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Unsupervised Deep Learning for Stroke Lesion Segmentation on Follow-up CT Based on Generative Adversarial Networks

H. van Voorst, P.R. Konduri, L.M. van Poppel, W. van der Steen, P.M. van der Sluijs, E.M.H. Slot, B.J. Emmer, W.H. van Zwam, Y.B.W.E.M. Roos, C.B.L.M. Majoie, G. Zaharchuk, M.W.A. Caan and H.A. Marquering on behalf of the CONTRAST Consortium Collaborators
American Journal of Neuroradiology August 2022, 43 (8) 1107-1114; DOI: https://doi.org/10.3174/ajnr.A7582
H. van Voorst
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for H. van Voorst
P.R. Konduri
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L.M. van Poppel
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L.M. van Poppel
W. van der Steen
dDepartments of Neurology (W.v.d.S., P.M.v.d.S.)
eRadiology and Nuclear Medicine (W.v.d.S., P.M.v.d.S.), Erasmus University Medical Center, Rotterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for W. van der Steen
P.M. van der Sluijs
dDepartments of Neurology (W.v.d.S., P.M.v.d.S.)
eRadiology and Nuclear Medicine (W.v.d.S., P.M.v.d.S.), Erasmus University Medical Center, Rotterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E.M.H. Slot
fDepartment of Neurology and Neurosurgery (E.M.H.S.), University Medical Center Utrecht, Utrecht, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B.J. Emmer
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B.J. Emmer
W.H. van Zwam
gDepartment of Radiology and Nuclear Medicine (W.H.v.Z.), Maastricht University Medical Center, Maastricht, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for W.H. van Zwam
Y.B.W.E.M. Roos
cNeurology (Y.B.W.E.M.R.), Faculty of Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y.B.W.E.M. Roos
C.B.L.M. Majoie
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C.B.L.M. Majoie
G. Zaharchuk
hDepartment of Radiology (G.Z.), Stanford University, Stanford, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Zaharchuk
M.W.A. Caan
bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.W.A. Caan
H.A. Marquering
aFrom the Departments of Radiology and Nuclear Medicine (H.v.V., P.R.K., L.M.v.P., B.J.E., C.B.L.M.M., H.A.M.)
bBiomedical Engineering and Physics (H.v.V., P.R.K., L.M.v.P., M.W.A.C., H.A.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for H.A. Marquering
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Katramados AM,
    2. Hacein-Bey L,
    3. Varelas PN
    . What to look for on post-stroke neuroimaging. Neuroimaging Clin N Am 2018;28:649–62 doi:10.1016/j.nic.2018.06.007 pmid:30322600
    CrossRefPubMed
  2. 2.↵
    1. Park TH,
    2. Lee JK,
    3. Park MS, et al
    . Neurologic deterioration in patients with acute ischemic stroke or transient ischemic attack. Neurology 2020;95:e2178–91 doi:10.1212/WNL.0000000000010603 pmid:32817184
    CrossRefPubMed
  3. 3.↵
    1. Seners P,
    2. Turc G,
    3. Oppenheim C, et al
    . Incidence, causes and predictors of neurological deterioration occurring within 24 h following acute ischaemic stroke: a systematic review with pathophysiological implications. J Neurol Neurosurg Psychiatry 2015;86:87–94 doi:10.1136/jnnp-2014-308327 pmid:24970907
    Abstract/FREE Full Text
  4. 4.↵
    1. Karthik R,
    2. Menaka R,
    3. Johnson A, et al
    . Neuroimaging and deep learning for brain stroke detection: a review of recent advancements and future prospects. Comput Methods Programs Biomed 2020;197:105728 doi:10.1016/j.cmpb.2020.105728 pmid:32882591
    CrossRefPubMed
  5. 5.↵
    1. Yeo M,
    2. Tahayori B,
    3. Kok HK, et al
    . Review of deep learning algorithms for the automatic detection of intracranial hemorrhages on computed tomography head imaging. J Neurointerv Surg 2020;13:369–78 doi:10.1136/neurintsurg-2020-01709]9 pmid:33479036
    CrossRefPubMed
  6. 6.↵
    1. Boers AM,
    2. Jansen IG,
    3. Beenen LF, et al
    . Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials. J Neurointerv Surg 2018;10:1137–42 doi:10.1136/neurintsurg-2017-013724 pmid:29627794
    Abstract/FREE Full Text
  7. 7.↵
    1. Hemphill JC,
    2. Greenberg SM,
    3. Anderson CS
    , et al; Council on Clinical Cardiology. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: a Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke 2015;46:2032–60 doi:10.1161/STR.0000000000000069 pmid:26022637
    Abstract/FREE Full Text
  8. 8.↵
    1. Barros RS,
    2. van der Steen WE,
    3. Boers AMM, et al
    . Automated segmentation of subarachnoid hemorrhages with convolutional neural networks. Informatics Med Unlocked 2020;19:100321 doi:10.1016/j.imu.2020.100321
    CrossRef
  9. 9.↵
    1. Barros RS,
    2. Tolhuisen ML,
    3. Boers AM, et al
    . Automatic segmentation of cerebral infarcts in follow-up computed tomography images with convolutional neural networks. J Neurointerv Surg 2020;12:848–52 doi:10.1136/neurintsurg-2019-015471 pmid:31871069
    Abstract/FREE Full Text
  10. 10.↵
    1. Zhao X,
    2. Chen K,
    3. Wu G, et al
    . Deep learning shows good reliability for automatic segmentation and volume measurement of brain hemorrhage, intraventricular extension, and peripheral edema. Eur Radiol 2021;31:5012–20 doi:10.1007/s00330-020-07558-2 pmid:33409788
    CrossRefPubMed
  11. 11.↵
    1. Goodfellow I,
    2. Bengio Y,
    3. Courville A
    . Deep learning. MIT Press 2016. deeplearningbook.org. Accessed July 11, 2022
  12. 12.↵
    1. Yi X,
    2. Walia E,
    3. Babyn P
    . Generative adversarial network in medical imaging: a review. Med Image Anal 2019;58:101552 doi:10.1016/j.media.2019.101552] pmid:31521965
    CrossRefPubMed
  13. 13.↵
    1. Goodfellow IJ,
    2. Pouget-Abadie J,
    3. Mirza M, et al
    . Generative adversarial nets. Adv Neural Inf Process Syst 2014;3:2672–80
  14. 14.↵
    1. Baumgartner CF,
    2. Koch LM,
    3. Tezcan KM, et al
    . Visual Feature Attribution using Wasserstein GANs. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, Salt Lake City, Utah. June 18–23, 2018:8309–19
  15. 15.↵
    1. Treurniet KM,
    2. LeCouffe NE,
    3. Kappelhof M, et al
    ; MR CLEAN-NO IV Investigators. MR CLEAN-NO IV: intravenous treatment followed by endovascular treatment versus direct endovascular treatment for acute ischemic stroke caused by a proximal intracranial occlusion—study protocol for a randomized clinical trial. Trials 2021;22:1–15 doi:10.1186/s13063-021-05063-5 pmid:33397449
    CrossRefPubMed
  16. 16.↵
    1. Chalos V,
    2. Van De Graaf RA,
    3. Roozenbeek B, et al
    ; MR CLEAN-MED investigators. Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke: the effect of periprocedural medication—acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design. Trials 2020;21:1–17 doi:10.1186/s13063-020-04514-9 pmid:31898511
    CrossRefPubMed
  17. 17.↵
    1. Pirson FA,
    2. Hinsenveld WH,
    3. Goldhoorn R-JB, et al
    ; MR CLEAN-LATE investigators. MR CLEAN-LATE study protocol. Trials 2021;22:160 doi:10.1186/s13063-021-05092-0 33627168 pmid:33627168
    CrossRefPubMed
  18. 18.↵
    1. Konduri P,
    2. van Kranendonk K,
    3. Boers A, et al
    ; MR CLEAN Trial Investigators (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). The role of edema in subacute lesion progression after treatment of acute ischemic stroke. Front Neurol 2021;12:705221 doi:10.3389/fneur.2021.705221 pmid:34354669
    CrossRefPubMed
  19. 19.↵
    1. Hssayeni MD,
    2. Croock MS,
    3. Salman AD, et al
    . Intracranial hemorrhage segmentation using a deep convolutional model. Data 2020;5:14–18 doi:10.3390/data5010014
    CrossRef
  20. 20.↵
    1. Van Kranendonk KR,
    2. Treurniet KM,
    3. Boers AM
    , et al; MR CLEAN investigators. Hemorrhagic transformation is associated with poor functional outcome in patients with acute ischemic stroke due to a large vessel occlusion. J Neurointerv Surg 2019;11:464–68 doi:10.1136/neurintsurg-2018-014141 pmid:30297537
    Abstract/FREE Full Text
  21. 21.↵
    1. Berkhemer OA,
    2. Fransen PS,
    3. Beumer D
    , et al. MR CLEAN Investigators, A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 2015;372:11–20 doi:10.1056/NEJMoa1411587 pmid:25517348
    CrossRefPubMedWeb of Science
  22. 22.↵
    dcm2niix. 2021. https://github.com/rordenlab/dcm2niix. Accessed November 3, 2021
  23. 23.↵
    1. Klein S,
    2. Staring M,
    3. Murphy K, et al
    . Elastix: a toolbox for intensity-based medical image registration. IEEE Trans Med Imaging 2010;29:196–205 doi:10.1109/TMI.2009.2035616 pmid:19923044
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Isensee F,
    2. Jaeger PF,
    3. Kohl SA, et al
    . nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation. Nat Methods 2021;18:203–11 doi:10.1038/s41592-020-01008-z pmid:33288961
    CrossRefPubMed
  25. 25.↵
    1. Kuang H,
    2. Menon BK,
    3. Qiu W
    . Automated stroke lesion segmentation in non-contrast CT scans using dense multi-path contextual generative adversarial network. Phys Med Biol 2020;65:215013 doi:10.1088/1361-6560/aba166 pmid:32604080
    CrossRefPubMed
  26. 26.↵
    1. Lin TY,
    2. Goyal P,
    3. Girshick R, et al
    . Focal loss for dense object detection. IEEE Trans Pattern Anal Mach Intel 2020;42:318–27 doi:10.1109/TPAMI.2018.285882]6 pmid:30040631
    CrossRefPubMed
  27. 27.↵
    1. Flanders AE,
    2. Prevedello LM,
    3. Shih G, et al
    ; RSNA-ASNR 2019 Brain Hemorrhage CT Annotators. Construction of a Machine Learning Dataset through Collaboration: The RSNA 2019 Brain CT Hemorrhage Challenge. Radiology Artif Intell 2020;2:e209002 doi:10.1148/ryai.2020209002 pmid:33939782
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 43 (8)
American Journal of Neuroradiology
Vol. 43, Issue 8
1 Aug 2022
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Unsupervised Deep Learning for Stroke Lesion Segmentation on Follow-up CT Based on Generative Adversarial Networks
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
H. van Voorst, P.R. Konduri, L.M. van Poppel, W. van der Steen, P.M. van der Sluijs, E.M.H. Slot, B.J. Emmer, W.H. van Zwam, Y.B.W.E.M. Roos, C.B.L.M. Majoie, G. Zaharchuk, M.W.A. Caan, H.A. Marquering
Unsupervised Deep Learning for Stroke Lesion Segmentation on Follow-up CT Based on Generative Adversarial Networks
American Journal of Neuroradiology Aug 2022, 43 (8) 1107-1114; DOI: 10.3174/ajnr.A7582

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Unsupervised DL for Stroke Lesion Segmentation
H. van Voorst, P.R. Konduri, L.M. van Poppel, W. van der Steen, P.M. van der Sluijs, E.M.H. Slot, B.J. Emmer, W.H. van Zwam, Y.B.W.E.M. Roos, C.B.L.M. Majoie, G. Zaharchuk, M.W.A. Caan, H.A. Marquering
American Journal of Neuroradiology Aug 2022, 43 (8) 1107-1114; DOI: 10.3174/ajnr.A7582
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

Adult Brain

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Functional

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • WM Neuroaxonal Loss in Type 1 Diabetes
Show more Functional

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire