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Research ArticleSpine

Contribution of the MP2RAGE 7T Sequence in MS Lesions of the Cervical Spinal Cord

B. Testud, N. Fabiani, S. Demortière, S. Mchinda, N.L. Medina, J. Pelletier, M. Guye, B. Audoin, J.P. Stellmann and V. Callot
American Journal of Neuroradiology September 2023, 44 (9) 1101-1107; DOI: https://doi.org/10.3174/ajnr.A7964
B. Testud
aFrom the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
bAssistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France
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N. Fabiani
aFrom the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
bAssistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France
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S. Demortière
aFrom the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
bAssistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France
cDepartment of Neurology (S.D., J.P., B.A.), Assistance Publique-Hopitaux de Marseille, Hôpital Universitaire Timone, Marseille, France.
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S. Mchinda
aFrom the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
bAssistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France
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N.L. Medina
aFrom the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
bAssistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France
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J. Pelletier
aFrom the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
bAssistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France
cDepartment of Neurology (S.D., J.P., B.A.), Assistance Publique-Hopitaux de Marseille, Hôpital Universitaire Timone, Marseille, France.
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M. Guye
aFrom the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
bAssistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France
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B. Audoin
aFrom the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
bAssistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France
cDepartment of Neurology (S.D., J.P., B.A.), Assistance Publique-Hopitaux de Marseille, Hôpital Universitaire Timone, Marseille, France.
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J.P. Stellmann
aFrom the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
bAssistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France
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V. Callot
aFrom the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
bAssistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France
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    FIG 1.

    Proportion of lesion detection by sequence (A) and by sequence per vertebral level (B) for the patients having the 4 imaging sets (14 patients). The number of lesions (n) is detected for each cervical level.

  • FIG 2.
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    FIG 2.

    Axial presentation at the C4 level for patient P11. Images were acquired with the T2*-WI GRE (A), 3T UNI MP2RAGE (B), 7T isotropic UNI MP2RAGE (C), and 7T anisotropic UNI MP2RAGE (D) sequences. The posterior lesion was visible on each image, the right lateral lesion was not visible on the 3T UNI MP2RAGE sequence (B), and the left lateral lesion (white arrowhead) was only detected with the 7T anisotropic UNI MP2RAGE sequence (D).

  • FIG 3.
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    FIG 3.

    A patient P13 presenting with a C4 left lateral lesion (arrowhead). The lesion was not detected on axial T2*-WI GRE image (A), the 3T UNI MP2RAGE (B), nor the 7T isotropic UNI MP2RAGE (C). It was only detected using the 7T anisotropic UNI MP2RAGE (D).

  • FIG 4.
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    FIG 4.

    Patient P17 presented with a small lesion (arrowhead) in contact with the anterior fissure of the spinal cord at the C1–C2 level. The lesion was seen on a T2*-WI GRE (A) image, not seen on 3T UNI MP2RAGE (B), and easily seen on 7T anisotropic UNI MP2RAGE (C) image.

  • FIG 5.
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    FIG 5.

    Patient P3 presented with a small posterior lesion (white arrowhead) at the C1 level that was not seen on axial T2*-WI GRE (A) image nor with 3T UNI MP2RAGE (B). At 7T, the lesion was seen on the axial plane of the isotropic UNI MP2RAGE sequence (C), but it was not seen on the anisotropic 7T UNI MP2RAGE image (D). The sagittal plane (E) of the 7T isotropic UNI MP2RAGE sequence shows that this lesion (white arrowhead) has a small height. This lesion is not seen on the sagittal 3T UNI MP2RAGE (F). Additional lesions (white arrows) can be seen at the C3 and C5 levels on both sagittal planes (E and F).

Tables

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    Table 1:

    Main sequence parameters

    Magnetic Field3T7T
    SequenceT2*-WIT2WISTIR-WIMP2RAGEMP2RAGE IsotropicMP2RAGE Anisotropic
    Dimension/orientation2D2D2D3D3D3D
    AxialSagittalSagittalSagittalCoronalAxial
    TR (sec)0.543.2455
    TE (ms)27113532.482.153.05
    FOV (mm)180280320300260256
    Resolution (mm3)0.5 × 0.5 × 51.1 × 0.9 × 20.9 × 0.7 × 30.9 × 0.9 × 0.90.7 × 0.7 × 0.70.3 × 0.3 × 4
    Slices9 Per slab,17619264 Slices per slab,
    2 Slabsa1 or 2 Slabsa,b
    Acq. time (min)5.261.542.187.188.476.02/Slab
    • Note:—Acq. indicates acquisition.

    • ↵a Placed perpendicular to the cord.

    • ↵b Depending on cord curvature.

    • View popup
    Table 2:

    Demographic and clinical characteristics

    PatientsAge (yr)SexDisease CourseDisease Duration (mo)EDSSLesion Count
    P140MRR9527
    P2a20FRR582.53
    P330FRR871.56
    P427FRR1736
    P523FRR4705
    P631FRR600
    P735FRR3313
    P828FRR603
    P938FRR710
    P1033MRR1703
    P1131FRR189012
    P1241FRR4517
    P1326MRR1203
    P1420MRR4400
    P1530FRR1010
    P16a35MRR11212
    P17a26FRR1018
    • Note:—RR indicates relapsing-remitting; F, female; M, male; EDSS, Expanded Disability Status Scale.

    • ↵a The patients who could not have the examination with the 7T isotropic MP2RAGE sequence.

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American Journal of Neuroradiology: 44 (9)
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Vol. 44, Issue 9
1 Sep 2023
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B. Testud, N. Fabiani, S. Demortière, S. Mchinda, N.L. Medina, J. Pelletier, M. Guye, B. Audoin, J.P. Stellmann, V. Callot
Contribution of the MP2RAGE 7T Sequence in MS Lesions of the Cervical Spinal Cord
American Journal of Neuroradiology Sep 2023, 44 (9) 1101-1107; DOI: 10.3174/ajnr.A7964

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MP2RAGE 7T in MS Lesions of the Cervical Spine
B. Testud, N. Fabiani, S. Demortière, S. Mchinda, N.L. Medina, J. Pelletier, M. Guye, B. Audoin, J.P. Stellmann, V. Callot
American Journal of Neuroradiology Sep 2023, 44 (9) 1101-1107; DOI: 10.3174/ajnr.A7964
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