Index by author

The Bern score quantitatively characterizes brain MR imaging changes in spontaneous intracranial hypotension. This imaging biomarker was shown to have a low correlation with clinical headache severity and, therefore, imaging findings in isolation may have limited utility as primary outcome measures when assessing treatment response.

Cerebral physiologic changes occur in response to the unique physiologic stressor of altered gravity, including a decrease in global perfusion and increase in ventricular/PVS volumes during spaceflight analog and subsequent reversal during recovery. The findings of this study contribute to our understanding of the relationships among the circulatory, glymphatic, and ventricular systems of the brain.