Effect of Clot Burden Score on Safety and Efficacy of Intravenous Alteplase Prior to Mechanical Thrombectomy in Acute Ischemic Stroke: A Subgroup Analysis of a Randomized Phase 3 Trial

REFERENCES

1. 1.↵
   1. Goyal M,
   2. Menon BK,
   3. van Zwam WH

   ; HERMES Collaborators, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 2016;387:1723–31 doi:10.1016/S0140-6736(16)00163-X pmid:26898852

   CrossRefPubMed
2. 2.↵
   1. Rohan V,
   2. Baxa J,
   3. Tupy R, et al

   . Length of occlusion predicts recanalization and outcome after intravenous thrombolysis in middle cerebral artery stroke. Stroke 2014;45:2010–17 doi:10.1161/STROKEAHA.114.005731 pmid:24916912

   Abstract/FREE Full Text
3. 3.↵
   1. Riedel CH,
   2. Zimmermann P,
   3. Jensen-Kondering U, et al

   . The importance of size: successful recanalization by intravenous thrombolysis in acute anterior stroke depends on thrombus length. Stroke 2011;42:1775–77 doi:10.1161/STROKEAHA.110.609693 pmid:21474810

   Abstract/FREE Full Text
4. 4.↵
   1. Li G,
   2. Wu G,
   3. Qin Z, et al

   . Prognostic value of clot burden score in acute ischemic stroke after reperfusion therapies: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis 2019;28:104293 doi:10.1016/j.jstrokecerebrovasdis.2019.07.009 pmid:31383621

   CrossRefPubMed
5. 5.↵
   1. Legrand L,
   2. Naggara O,
   3. Turc G, et al

   . Clot burden score on admission T2*-MRI predicts recanalization in acute stroke. Stroke 2013;44:1878–84 doi:10.1161/STROKEAHA.113.001026 pmid:23704103

   Abstract/FREE Full Text
6. 6.↵
   1. Yogendrakumar V,
   2. Al-Ajlan F,
   3. Najm M, et al

   . Clot burden score and early ischemia predict intracranial hemorrhage following endovascular therapy. AJNR Am J Neuroradiol 2019;40:655–60

   Abstract/FREE Full Text
7. 7.↵
   1. Treurniet KM,
   2. Yoo AJ,
   3. Berkhemer OA

   ; MR CLEAN Investigators, et al. Clot burden score on baseline computerized tomographic angiography and intra-arterial treatment effect in acute ischemic stroke. Stroke 2016;47:2972–78 doi:10.1161/STROKEAHA.116.014565 pmid:27827328

   Abstract/FREE Full Text
8. 8.↵
   1. Yang P,
   2. Treurniet KM,
   3. Zhang L

   ; DIRECT-MT Investigators, et al. Direct intra-arterial thrombectomy in order to revascularize AIS patients with large vessel occlusion efficiently in Chinese tertiary hospitals: a multicenter randomized clinical trial (DIRECT-MT)-protocol. Int J Stroke 2020;15:689–98 doi:10.1177/1747493019882837 pmid:31663831

   CrossRefPubMed
9. 9.↵
   1. Yang P,
   2. Zhang Y,
   3. Zhang L

   ; DIRECT-MT Investigators, et al. Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med 2020;382:1981–93 doi:10.1056/NEJMoa2001123 pmid:32374959

   CrossRefPubMed
10. 10.↵
    1. Puetz V,
    2. Dzialowski I,
    3. Hill MD

    ; Calgary CTA Study Group, et al. Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden score. Int J Stroke 2008;3:230–36 doi:10.1111/j.1747-4949.2008.00221.x pmid:18811738

    CrossRefPubMedWeb of Science
11. 11.↵
    1. von Kummer R,
    2. Broderick JP,
    3. Campbell BC, et al

    . The Heidelberg Bleeding Classification: classification of bleeding events after ischemic stroke and reperfusion therapy. Stroke 2015;46:2981–86 doi:10.1161/STROKEAHA.115.010049 pmid:26330447

    FREE Full Text
12. 12.
    1. Eilaghi A,
    2. Brooks J,
    3. d’Esterre C, et al

    . Reperfusion is a stronger predictor of good clinical outcome than recanalization in ischemic stroke. Radiology 2013;269:240–48 doi:10.1148/radiol.13122327 pmid:23716707

    CrossRefPubMedWeb of Science
13. 13.
    1. Derraz I,
    2. Pou M,
    3. Labreuche J

    ; ASTER and the THRACE Trials Investigators, et al. Clot burden score and collateral status and their impact on functional outcome in acute ischemic stroke. AJNR Am J Neuroradiol 2021;42:42–48 doi:10.3174/ajnr.A6865 pmid:33184069

    Abstract/FREE Full Text
14. 14.
    1. Derraz I,
    2. Bourcier R,
    3. Soudant M

    ; THRACE Investigators, et al. Does clot burden score on baseline T2*-MRI impact clinical outcome in acute ischemic stroke treated with mechanical thrombectomy? J Stroke 2019;21:91–100 doi:10.5853/jos.2018.01921 pmid:30732444

    CrossRefPubMed
15. 15.↵
    1. Zhou Y,
    2. Xing P,
    3. Li Z

    ; DIRECT-MT Investigators, et al. Effect of occlusion site on the safety and efficacy of intravenous alteplase before endovascular thrombectomy: a prespecified subgroup analysis of DIRECT-MT. Stroke 2022;53:7–16 doi:10.1161/STROKEAHA.121.035267 pmid:34915738

    CrossRefPubMed
16. 16.↵
    1. Zhou Y,
    2. Zhang L,
    3. Ospel J

    ; DIRECT-MT Investigators, et al. Association of intravenous alteplase, early reperfusion, and clinical outcome in patients with large vessel occlusion stroke: post hoc analysis of the randomized DIRECT-MT trial. Stroke 2022;53:1828–36 doi:10.1161/STROKEAHA.121.037061 pmid:35240861

    CrossRefPubMed
17. 17.↵
    1. Boeckh-Behrens T,
    2. Kleine JF,
    3. Zimmer C, et al

    . Thrombus histology suggests cardioembolic cause in cryptogenic stroke. Stroke 2016;47:1864–71 doi:10.1161/STROKEAHA.116.013105 pmid:27197854

    Abstract/FREE Full Text
18. 18.↵
    1. Nguyen TN,
    2. Fischer U

    . Treatment effect of intravenous thrombolysis bridging to mechanical thrombectomy on vessel occlusion site. Stroke 2022;53:17–19 doi:10.1161/STROKEAHA.121.037603 pmid:34915740

    CrossRefPubMed
19. 19.↵
    1. Gerschenfeld G,
    2. Muresan IP,
    3. Blanc R, et al

    . Two paradigms for endovascular thrombectomy after intravenous thrombolysis for acute ischemic stroke. JAMA Neurol 2017;74:549–56 doi:10.1001/jamaneurol.2016.5823 pmid:28319240

    CrossRefPubMed
20. 20.↵
    1. Mueller L,
    2. Pult F,
    3. Meisterernst J, et al

    . Impact of intravenous thrombolysis on recanalization rates in patients with stroke treated with bridging therapy. Eur J Neurol 2017;24:1016–21 doi:10.1111/ene.13330 pmid:28649759

    CrossRefPubMed
21. 21.↵
    1. LeCouffe NE,
    2. Kappelhof M,
    3. Treurniet KM

    ; MR CLEAN–NO IV Investigators, et al. A randomized trial of intravenous alteplase before endovascular treatment for stroke. N Engl J Med 2021;385:1833–44 doi:10.1056/NEJMoa2107727 pmid:34758251

    CrossRefPubMed
22. 22.↵
    1. Suzuki K,
    2. Matsumaru Y,
    3. Takeuchi M

    ; SKIP Study Investigators, et al. Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized clinical trial. JAMA 2021;325:244–53 doi:10.1001/jama.2020.23522 pmid:33464334

    CrossRefPubMed
23. 23.↵
    1. Seners P,
    2. Turc G,
    3. Maier B, et al

    . Incidence and predictors of early recanalization after intravenous thrombolysis: a systematic review and meta-analysis. Stroke 2016;47:2409–12 doi:10.1161/STROKEAHA.116.014181 pmid:27462117

    Abstract/FREE Full Text
24. 24.↵
    1. Arrarte Terreros N,
    2. Bruggeman AA,
    3. Swijnenburg IS, et al

    . Early recanalization in large-vessel occlusion stroke patients transferred for endovascular treatment. J Neurointerv Surg 2022;14:480–84 doi:10.1136/neurintsurg-2021-017441 pmid:33986112

    Abstract/FREE Full Text
25. 25.↵
    1. Menon BK,
    2. Al-Ajlan FS,
    3. Najm M

    ; INTERRSeCT Study Investigators, et al. Association of clinical, imaging, and thrombus characteristics with recanalization of visible intracranial occlusion in patients with acute ischemic stroke. JAMA 2018;320:1017–26 doi:10.1001/jama.2018.12498 pmid:30208455

    CrossRefPubMed
26. 26.↵
    1. Mistry EA,
    2. Mistry AM,
    3. Nakawah MO, et al

    . Mechanical thrombectomy outcomes with and without intravenous thrombolysis in stroke patients: a meta-analysis. Stroke 2017;48:2450–56 doi:10.1161/STROKEAHA.117.017320 pmid:28747462

    Abstract/FREE Full Text
27. 27.↵
    1. Shehabeldin M,
    2. Eby B,
    3. Wallace AN, et al

    . Effect of intravenous thrombolysis on clot survival during mechanical thrombectomy in acute large vessel occlusion strokes. Neurosurgery 2021;89:1027–32 doi:10.1093/neuros/nyab344 pmid:34528088

    CrossRefPubMed
28. 28.↵
    1. Rossi R,
    2. Fitzgerald S,
    3. Molina S, et al

    . The administration of rtPA before mechanical thrombectomy in acute ischemic stroke patients is associated with a significant reduction of the retrieved clot area but it does not influence revascularization outcome. J Thromb Thrombolysis 2021;51:545–51 doi:10.1007/s11239-020-02279-1 pmid:32936433

    CrossRefPubMed
29. 29.↵
    1. Goyal N,
    2. Tsivgoulis G,
    3. Pandhi A, et al

    . Impact of pretreatment with intravenous thrombolysis on reperfusion status in acute strokes treated with mechanical thrombectomy. J Neurointerv Surg 2019;11:1073–79 doi:10.1136/neurintsurg-2019-014746 pmid:31088941

    Abstract/FREE Full Text
30. 30.↵
    1. van der Steen W,
    2. van de Graaf RA,
    3. Chalos V

    ; MR CLEAN-MED Investigators, et al. Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial. Lancet 2022;399:1059–69 doi:10.1016/S0140-6736(22)00014-9 pmid:35240044

    CrossRefPubMed