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Research ArticlePediatric Neuroimaging

The Clinical Value of Cranial CT Venography for Predicting Fusobacterium necrophorum as the Causative Agent in Children with Complicated Acute Mastoiditis

Shelly I. Shiran, Li-tal Pratt, Ari DeRowe, Sophie Matot, Narin Carmel Neiderman and Oshri Wasserzug
American Journal of Neuroradiology June 2024, 45 (6) 761-768; DOI: https://doi.org/10.3174/ajnr.A8217
Shelly I. Shiran
aFrom the Department of Radiology (S.I.S., L.-t.P.), Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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  • ORCID record for Shelly I. Shiran
Li-tal Pratt
aFrom the Department of Radiology (S.I.S., L.-t.P.), Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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Ari DeRowe
bPediatric Otorhinolaryngology Unit, “Dana” Children’s Hospital (A.D., O.W.), Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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Sophie Matot
cDepartment of Otolaryngology, Head & Neck and Maxillofacial Surgery (S.M., N.C.N.), Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Narin Carmel Neiderman
cDepartment of Otolaryngology, Head & Neck and Maxillofacial Surgery (S.M., N.C.N.), Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Oshri Wasserzug
bPediatric Otorhinolaryngology Unit, “Dana” Children’s Hospital (A.D., O.W.), Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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Article Figures & Data

Figures

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  • FIG 1.
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    FIG 1.

    Perisigmoid abscess classification in 4 different cases of complicated mastoiditis: class I (A), normal dura with no thickening; class II (B), linear smooth halo of thickened dura (arrows); class III (C), focal nodular dural thickening ≤4 mm thick (arrow); class IV (D), large nodular halo >4 mm thick (arrow). Classes III and IV comprise the patients considered positive for perisigmoid abscess on imaging. Note that there is an extracranial subperiosteal abscess present in B and C (arrowhead).

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    FIG 2.

    The prevalence of bacteria species in the non-F necrophorum–related disease group.

  • FIG 3.
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    FIG 3.

    A 9-month-old old boy with F necrophorum–related left-sided CAM causing otogenic Lemierre syndrome variant. Axial CTV image (A) at the level of the sigmoid sinus demonstrates an obstructing filling defect in the left sigmoid sinus consistent with SVT (white arrows), as apposed to normal contrast filling in the right sigmoid sinus (black arrow). No contrast is seen in the left IJV (white arrowhead) with normal contrast filling in the right IJV (black arrowhead). Also note extensive retroauricular soft-tissue phlegmon (asterisk). Sagittal-oblique MPR centered on the left jugular bulb (B) demonstrates extension of thrombus with complete obstruction of the jugular bulb and proximal IJV, with abrupt transition (arrow) where the thrombus ends. Coronal reformat of the sella region (C) demonstrates asymmetric contrast enhancement of the cavernous sinuses with a filling defect on the left (arrow), consistent with thrombosis. Coronal reformat of the orbits (D) demonstrates thrombophlebitis of the right superior ophthalmic vein with enhancement and fat-stranding along the obstructed vein (arrow).

  • FIG 4.
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    FIG 4.

    Extramastoid osteomyelitis–related bone changes in 3 different children with F necrophorum–related CAM. A 3-year-old girl (A) with left mastoid CAM. The mastoid air cells are opacified bilaterally, but only on the left is there demineralization of the mastoid sinus plate as well as extension of focal cortical lytic changes posteriorly along the left sigmoid plate, consistent with subtle extramastoid osteomyelitis (arrows). A 2-year-old boy (B) with right-sided CAM with more extensive destructive bone changes posterior and anterior to the mastoid (arrows). A 4-year-old boy (C) with left-sided CAM has abnormal air deposits in the nonpneumatized sphenoid bone, consistent with emphysematous osteomyelitis (circle). Note also the presence of SVT in the left jugular bulb (arrow).

  • FIG 5.
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    FIG 5.

    An 11-month-old girl with F necrophorum–related right-sided CAM with TMJ abscess. Coronal reformat (A) and axial (B) CTV images demonstrate a large subperiosteal abscess (arrows) extending to the zygomatic arch and into the glenoid fossa of the right TMJ.

  • FIG 6.
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    FIG 6.

    A 4-year-old boy with left-sided F necrophorum–related CAM complicated with a pumice bone pattern extramastoid osteomyelitis. The hallmark of this pattern is abnormal air deposits in a nonpneumatized bone without extensive cortical destruction, as seen in this child. Axial CTV image in a soft-tissue window (A) and in the bone algorithm (B) demonstrates abnormal air deposits in the nonpneumatized clivus (white arrows). A sagittal reformat (C) shows that both sphenoidal and basilar parts of the clivus are involved (arrows), distinguished from the sphenoid sinus that has mucosal thickening (asterisk). Similar changes are seen in the left petrous apex (arrow) (D) compared with the normal bone in the right petrous apex. Note also the presence of SVT in the left jugular bulb (back arrow) (A).

Tables

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    Table 1:

    Results

    FindingFusobacterium (n = 37)Other (n = 39)P Value
    Male/female ratio19:18 (1.01)23:16 (1.4).967
    Site of ear infection RT:LT ratio19:18 (1.01)22:17 (1.3).658
    Chronic ear changes6 (16%)5 (13%).674
    Intracranial perisigmoid epidural abscess27 (73%)16 (41%).036
    Intracranial middle cranial fossa epidural abscess10 (27%)4 (10%).199
    Subdural empyema1 (2.7%)1 (2.6%)1
    SVT24 (64%)4 (10%)< .001
    Extramastoid bone changes consistent with osteomyelitis20 (54%)4 (10%)< .001
    Emphysematous osteomyelitis8 (22%)0.015
    Subperiosteal abscess30 (81%)30 (77%)1
    Inflammatory phlegmon (mild and extensive)34 (92%)38 (97%).961
    TMJ abscess7 (19%)1 (2.6%).099
    Ipsilateral neck lymphadenopathy32 (87%)33 (85%)1
    Parotid hyperemia26 (70%)24 (62%).838
    Contralateral ear air cell opacification25 (68%)28 (72%)1
    Sinonasal air cell opacification (partial and complete)24 (65%)31 (79%).309
    • Note:—RT indicates right; LT, left.

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    Table 2:

    Sites of venous thrombosis

    Site of ThrombosisF necrophorum (n = 37)Other Bacteria (n = 39)
    Sigmoid sinus20 (54%)4 (10.3%)
    Transverse sinus3 (8%)0 (0%)
    Jugular fossa13 (35%)2 (5%)
    IJV8 (22%)0 (0%)
    Cavernous sinus6 (16%)0 (0%)
    Superior ophthalmic vein5 (14%)0 (0%)
    • View popup
    Table 3:

    The sensitivity, specificity, PPV, and NPV for statistically significant variables

    VariablePPVSensitivitySpecificityNPVF necrophorum (n = 37)Other Bacteria (n = 39)P Value Adjusted
    SVT0.8570.6490.8970.7324 (64%)4 (10%).000024
    Extramastoid osteomyelitis0.8330.5410.8970.6720 (54%)4 (10%).00036
    Perisigmoid epidural abscess0.630.730.590.6927 (73%)16 (43%).005
    SVT and extramastoid bone erosion10.45910.6617 (46%)0.000023
    SVT and perisigmoid epidural abscess0.8260.5140.8970.6619 (51%)4 (10%).0006
    Perisigmoid epidural abscess and extramastoid bone erosion0.8890.4320.9490.6416 (43%)2 (5%).00054
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American Journal of Neuroradiology: 45 (6)
American Journal of Neuroradiology
Vol. 45, Issue 6
1 Jun 2024
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Cite this article
Shelly I. Shiran, Li-tal Pratt, Ari DeRowe, Sophie Matot, Narin Carmel Neiderman, Oshri Wasserzug
The Clinical Value of Cranial CT Venography for Predicting Fusobacterium necrophorum as the Causative Agent in Children with Complicated Acute Mastoiditis
American Journal of Neuroradiology Jun 2024, 45 (6) 761-768; DOI: 10.3174/ajnr.A8217

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CTV for Fusobacterium Necrophorum in Mastoiditis
Shelly I. Shiran, Li-tal Pratt, Ari DeRowe, Sophie Matot, Narin Carmel Neiderman, Oshri Wasserzug
American Journal of Neuroradiology Jun 2024, 45 (6) 761-768; DOI: 10.3174/ajnr.A8217
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