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Research ArticleNeurodegenerative Disorder Imaging

Brainstem Chipmunk Sign: A Diagnostic Imaging Clue across All Subtypes of Alexander Disease

Thaís Armangue, Matthew T. Whitehead, Davide Tonduti, Laura Farina, Ali Reza Tavasoli, Arastoo Vossough, Mariko L. Bennett, Ylenia Vaia, Geneviève Bernard, Ettore Salsano, Saadet Mercimek-Andrews, Amy Waldman and Adeline Vanderver
American Journal of Neuroradiology June 2024, 45 (6) 769-772; DOI: https://doi.org/10.3174/ajnr.A8220
Thaís Armangue
aFrom the Neuroimmunology Program (T.A.), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic, University of Barcelona, Barcelona, Spain
bNeurology Department (T.A.), Neuroimmunology Unit, Sant Joan de Deu Children’s Hospital, University of Barcelona, Barcelona, Spain
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Matthew T. Whitehead
cDepartment of Radiology (M.T.W., A.Vossough), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
dPerelman School of Medicine (M.T.W., A.Vossough, A.W., A.Vanderver), University of Pennsylvania, Philadelphia, Pennsylvania
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  • ORCID record for Matthew T. Whitehead
Davide Tonduti
eUnit of Pediatric Neurology (D.T., Y.V.), Center for Diagnosis and Treatment of Leukodystrophies, V. Buzzi Children’s Hospital, University of Milan, Milan, Italy
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Laura Farina
fNeuroimaging Laboratory (L.F.), IRCCS Fondazione Santa Lucia, Rome, Italy
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Ali Reza Tavasoli
gDepartment of Neurology (A.R.T.), Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
hDepartment of Neurology (A.R.T.), Barrow Neurological Institute, Phoenix Children’s Hospital, Phoenix, Arizona
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  • ORCID record for Ali Reza Tavasoli
Arastoo Vossough
cDepartment of Radiology (M.T.W., A.Vossough), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
dPerelman School of Medicine (M.T.W., A.Vossough, A.W., A.Vanderver), University of Pennsylvania, Philadelphia, Pennsylvania
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Mariko L. Bennett
oDivision of Neurology (M.L.B., Y.V., A.W., A.Vanderver), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.
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Ylenia Vaia
eUnit of Pediatric Neurology (D.T., Y.V.), Center for Diagnosis and Treatment of Leukodystrophies, V. Buzzi Children’s Hospital, University of Milan, Milan, Italy
oDivision of Neurology (M.L.B., Y.V., A.W., A.Vanderver), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.
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Geneviève Bernard
iDepartments of Neurology and Neurosurgery, Pediatrics, and Human Genetics (G.B.), McGill University, Montreal, Quebec, Canada
jDepartment of Specialized Medicine (G.B.), Division of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada
kChild Health and Human Development Program (G.B.), Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
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Ettore Salsano
lUnit of Rare Neurological Diseases (E.S.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
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Saadet Mercimek-Andrews
mDepartment of Medical Genetics (S.M.-A.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
nThe Hospital for Sick Children (S.M.-A.), Toronto, Ontario, Canada
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Amy Waldman
dPerelman School of Medicine (M.T.W., A.Vossough, A.W., A.Vanderver), University of Pennsylvania, Philadelphia, Pennsylvania
oDivision of Neurology (M.L.B., Y.V., A.W., A.Vanderver), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.
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Adeline Vanderver
dPerelman School of Medicine (M.T.W., A.Vossough, A.W., A.Vanderver), University of Pennsylvania, Philadelphia, Pennsylvania
oDivision of Neurology (M.L.B., Y.V., A.W., A.Vanderver), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.
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Article Information

vol. 45 no. 6 769-772
DOI 
https://doi.org/10.3174/ajnr.A8220
PubMed 
38697787

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received November 29, 2023
  • Accepted after revision February 1, 2024
  • Published online June 7, 2024.

Copyright & Usage 
© 2024 by American Journal of Neuroradiology

Author Information

  1. Thaís Armanguea,b,
  2. Matthew T. Whiteheadc,d,
  3. Davide Tondutie,
  4. Laura Farinaf,
  5. Ali Reza Tavasolig,h,
  6. Arastoo Vossoughc,d,
  7. Mariko L. Bennetto,
  8. Ylenia Vaiae,o,
  9. Geneviève Bernardi,j,k,
  10. Ettore Salsanol,
  11. Saadet Mercimek-Andrewsm,n,
  12. Amy Waldmand,o and
  13. Adeline Vanderverd,o
  1. aFrom the Neuroimmunology Program (T.A.), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic, University of Barcelona, Barcelona, Spain
  2. bNeurology Department (T.A.), Neuroimmunology Unit, Sant Joan de Deu Children’s Hospital, University of Barcelona, Barcelona, Spain
  3. cDepartment of Radiology (M.T.W., A.Vossough), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
  4. dPerelman School of Medicine (M.T.W., A.Vossough, A.W., A.Vanderver), University of Pennsylvania, Philadelphia, Pennsylvania
  5. eUnit of Pediatric Neurology (D.T., Y.V.), Center for Diagnosis and Treatment of Leukodystrophies, V. Buzzi Children’s Hospital, University of Milan, Milan, Italy
  6. fNeuroimaging Laboratory (L.F.), IRCCS Fondazione Santa Lucia, Rome, Italy
  7. gDepartment of Neurology (A.R.T.), Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  8. hDepartment of Neurology (A.R.T.), Barrow Neurological Institute, Phoenix Children’s Hospital, Phoenix, Arizona
  9. iDepartments of Neurology and Neurosurgery, Pediatrics, and Human Genetics (G.B.), McGill University, Montreal, Quebec, Canada
  10. jDepartment of Specialized Medicine (G.B.), Division of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada
  11. kChild Health and Human Development Program (G.B.), Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
  12. lUnit of Rare Neurological Diseases (E.S.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
  13. mDepartment of Medical Genetics (S.M.-A.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
  14. nThe Hospital for Sick Children (S.M.-A.), Toronto, Ontario, Canada
  15. oDivision of Neurology (M.L.B., Y.V., A.W., A.Vanderver), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.
  1. Please address correspondence to Adeline Vanderver, MD, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Research Center 516H, Philadelphia, PA 19104; e-mail: Vandervera{at}chop.edu
View Full Text

Funding

  • Children’s National Medical Center, Department of Neurology (AV)

  • Carlos III Spanish Health Institute

    (CM14/00081, CV15/00021) (TA)

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  • Radiopaedia.org
    Frank Gaillard, Rohit Sharma, Travis Fahrenhorst-Jones
    2008
  • Diagnosing Alexander disease in adults
    David S Lynch, Charles Wade, Alise K Carlson, Frederik Barkhof, Tomokatsu Yoshida, Abigail Collins, Michael R Edwards, Amy T Waldman
    Practical Neurology 2025
  • Radiopaedia.org
    Frank Gaillard
    2024
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Cite this article
Thaís Armangue, Matthew T. Whitehead, Davide Tonduti, Laura Farina, Ali Reza Tavasoli, Arastoo Vossough, Mariko L. Bennett, Ylenia Vaia, Geneviève Bernard, Ettore Salsano, Saadet Mercimek-Andrews, Amy Waldman, Adeline Vanderver
Brainstem Chipmunk Sign: A Diagnostic Imaging Clue across All Subtypes of Alexander Disease
American Journal of Neuroradiology Jun 2024, 45 (6) 769-772; DOI: 10.3174/ajnr.A8220

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Brainstem Chipmunk Sign in Alexander Disease
Thaís Armangue, Matthew T. Whitehead, Davide Tonduti, Laura Farina, Ali Reza Tavasoli, Arastoo Vossough, Mariko L. Bennett, Ylenia Vaia, Geneviève Bernard, Ettore Salsano, Saadet Mercimek-Andrews, Amy Waldman, Adeline Vanderver
American Journal of Neuroradiology Jun 2024, 45 (6) 769-772; DOI: 10.3174/ajnr.A8220
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Cited By...

  • Diagnosing Alexander disease in adults
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Radiopaedia.org
    Frank Gaillard, Rohit Sharma, Travis Fahrenhorst-Jones
    2008
  • Diagnosing Alexander disease in adults
    David S Lynch, Charles Wade, Alise K Carlson, Frederik Barkhof, Tomokatsu Yoshida, Abigail Collins, Michael R Edwards, Amy T Waldman
    Practical Neurology 2025
  • Radiopaedia.org
    Frank Gaillard
    2024

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