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Improved Turnaround Times | Median time to first decision: 12 days

Abstract

Risk of seizures after myelography: comparison of iohexol and metrizamide.

P Maly, T Bach-Gansmo and D Elmqvist
American Journal of Neuroradiology September 1988, 9 (5) 879-883;
P Maly
Department of Diagnostic Radiology, Malmö General Hospital, Sweden.
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T Bach-Gansmo
Department of Diagnostic Radiology, Malmö General Hospital, Sweden.
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D Elmqvist
Department of Diagnostic Radiology, Malmö General Hospital, Sweden.
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Abstract

A parallel, double-blind, randomized study comparing iohexol and metrizamide--both 180 mg l/ml--in lumbar myelography was carried out in 60 consecutive patients. Eight to 15 ml of contrast medium were administered with the upper level at the middle thoracic column. A detailed neurologic examination was performed before and 24 hr after myelography. EEG recordings--evaluated visually and with fast Fourier transformation analysis--and somatosensory evoked responses were registered before, 6 hr after, and 24 hr after myelography. All patients were observed for adverse reactions for 24-48 hr. Iohexol did not produce any epileptiform activity but epileptiform activity was detected in five patients receiving metrizamide. Iohexol produced significantly less frequent and less severe EEG changes than did metrizamide both at visual evaluation (p less than .0025) and at fast Fourier transformation analysis (p less than .04). No significant changes occurred in the early components of the somatosensory evoked potentials after either contrast medium. Iohexol caused significantly (p less than .002) less frequent and less severe adverse reactions than did metrizamide. The neurologic examination revealed no changes of clinical importance with either contrast agent.

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American Journal of Neuroradiology
Vol. 9, Issue 5
1 Sep 1988
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P Maly, T Bach-Gansmo, D Elmqvist
Risk of seizures after myelography: comparison of iohexol and metrizamide.
American Journal of Neuroradiology Sep 1988, 9 (5) 879-883;

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Risk of seizures after myelography: comparison of iohexol and metrizamide.
P Maly, T Bach-Gansmo, D Elmqvist
American Journal of Neuroradiology Sep 1988, 9 (5) 879-883;
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