More articles from FUNCTIONAL
- Deep Learning–Based Detection of Intracranial Aneurysms in 3D TOF-MRA
In a retrospective study, the authors established a system for the detection of intracranial aneurysms from 3D TOF-MRA data. The system is based on an open-source neural network, originally developed for segmentation of anatomic structures in medical images. Eighty-five datasets of patients with a total of 115 intracranial aneurysms were used to train the system and evaluate its performance. Manual annotation of aneurysms based on radiologic reports and critical revision of image data served as the reference standard. The highest overall sensitivity of this system for the detection of intracranial aneurysms was 90% with a sensitivity of 96% for aneurysms with a diameter of 3–7 mm and 100% for aneurysms of >7 mm. The best location-dependent performance was in the posterior circulation.
- Radiomics-Based Intracranial Thrombus Features on CT and CTA Predict Recanalization with Intravenous Alteplase in Patients with Acute Ischemic Stroke
Sixty-seven patients with ICA/M1 MCA segment thrombus treated with IV alteplase were included in this analysis. Three hundred twenty-six radiomics features were extracted from each thrombus on both NCCT and CTA images. Linear discriminative analysis was applied to select features most strongly associated with early recanalization with IV alteplase. These features were then used to train a linear support vector machine classifier. Thrombus radiomics features derived from NCCT and CTA are more predictive of recanalization with IV alteplase in patients with acute ischemic stroke with proximal occlusion than previously known thrombus imaging features such as length, volume, and permeability.
- Improved White Matter Cerebrovascular Reactivity after Revascularization in Patients with Steno-Occlusive Disease
Thirty-five patients with steno-occlusive disease (Moyamoya disease [n = 24], Moyamoya syndrome [n = 3], atherosclerosis [n = 6], vasculitis [n = 1], and idiopathic stenosis [n = 1]) who underwent unilateral brain revascularization using a direct superficial temporal artery–to-MCA bypass were evaluated. WM cerebrovascular reactivity was measured preoperatively and postoperatively using BOLD MR imaging during iso-oxic hypercapnic changes in end-tidal carbon dioxide. WM cerebrovascular reactivity significantly improved after direct unilateral superficial temporal artery–to-MCA bypass in the revascularized hemisphere in the MCA territory and in the anterior cerebral artery territory.
- Abnormal Cerebral Perfusion Profile in Older Adults with HIV-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin-Labeling
CBF data from the UCSF HIV Over 60 Cohort and the Alzheimer Disease Neuroimaging Initiative were retrospectively evaluated to identify 19 HIV+ older adults, all with plasma viral suppression (including 5 with HIV-associated neurocognitive disorder); 13 healthy, age-matched controls; and 19 participants with early mild cognitive impairment. When accounting for age, education, sex, and vascular risk factors, the HIV+ participants demonstrated alterations in regional cerebral perfusion, including hypoperfusion of bilateral temporal, parietal, and occipital brain regions. This study found significant changes in specific CBF patterns associated with HIV status despite viral suppression.