Convolutional Neural Network–Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury

D.B. McCoy; S.M. Dupont; C. Gros; J. Cohen-Adad; R.J. Huie; A. Ferguson; X. Duong-Fernandez; L.H. Thomas; V. Singh; J. Narvid; L. Pascual; N. Kyritsis; M.S. Beattie; J.C. Bresnahan; S. Dhall; W. Whetstone; J.F. Talbott

doi:10.3174/ajnr.A6020

Research ArticleSpine Imaging and Spine Image-Guided Interventions

Open Access

Convolutional Neural Network–Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury

D.B. McCoy, S.M. Dupont, C. Gros, J. Cohen-Adad, R.J. Huie, A. Ferguson, X. Duong-Fernandez, L.H. Thomas, V. Singh, J. Narvid, L. Pascual, N. Kyritsis, M.S. Beattie, J.C. Bresnahan, S. Dhall, W. Whetstone and J.F. Talbott

American Journal of Neuroradiology March 2019, DOI: https://doi.org/10.3174/ajnr.A6020

D.B. McCoy

aFrom the Departments of Radiology and Biomedical Imaging (D.B.M., S.M.D., J.N., J.F.T.)

cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)

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S.M. Dupont

aFrom the Departments of Radiology and Biomedical Imaging (D.B.M., S.M.D., J.N., J.F.T.)

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C. Gros

fNeuroPoly Lab (C.G., J.C.-A.), Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, Quebec, Canada.

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J. Cohen-Adad

fNeuroPoly Lab (C.G., J.C.-A.), Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, Quebec, Canada.

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R.J. Huie

bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)

cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)

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A. Ferguson

bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)

cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)

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X. Duong-Fernandez

bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)

cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)

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L.H. Thomas

bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)

cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)

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V. Singh

dDepartments of Neurology (V.S.)

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J. Narvid

aFrom the Departments of Radiology and Biomedical Imaging (D.B.M., S.M.D., J.N., J.F.T.)

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L. Pascual

eOrthopedic Surgery (L.P.), Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California

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N. Kyritsis

bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)

cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)

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M.S. Beattie

bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)

cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)

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J.C. Bresnahan

bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)

cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)

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S. Dhall

bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)

cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)

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W. Whetstone

bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)

cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)

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J.F. Talbott

aFrom the Departments of Radiology and Biomedical Imaging (D.B.M., S.M.D., J.N., J.F.T.)

bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)

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DOI

https://doi.org/10.3174/ajnr.A6020

PubMed

30923086

Published By

American Journal of Neuroradiology

Print ISSN

0195-6108

Online ISSN

1936-959X

History

Received November 9, 2018
Accepted after revision February 11, 2019
Published online March 28, 2019.

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Author Information

D.B. McCoya,c,
S.M. Duponta,
C. Grosf,
J. Cohen-Adadf,
R.J. Huieb,c,
A. Fergusonb,c,
X. Duong-Fernandezb,c,
L.H. Thomasb,c,
V. Singhd,
J. Narvida,
L. Pascuale,
N. Kyritsisb,c,
M.S. Beattieb,c,
J.C. Bresnahanb,c,
S. Dhallb,c,
W. Whetstoneb,c and
J.F. Talbotta,b

^aFrom the Departments of Radiology and Biomedical Imaging (D.B.M., S.M.D., J.N., J.F.T.)
^bNeurological Surgery (R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W., J.F.T.)
^cBrain and Spinal Injury Center (D.B.M., R.J.H., A.F., X.D.-F., L.H.T., N.K., M.S.B., J.C.B., S.D., W.W.)
^dDepartments of Neurology (V.S.)
^eOrthopedic Surgery (L.P.), Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California
^fNeuroPoly Lab (C.G., J.C.-A.), Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, Quebec, Canada.

Please address correspondence to Jason F. Talbott, MD, PhD, Zuckerberg San Francisco General Hospital, 1001 Potrero Ave, Room 1X57C, San Francisco, CA 94110; e-mail: jason.talbott{at}ucsf.edu

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Funding

Department of Defense
SC120259
Craig H. Neilsen Foundation

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Convolutional Neural Network–Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury

American Journal of Neuroradiology Mar 2019, DOI: 10.3174/ajnr.A6020

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Convolutional Neural Network–Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury

American Journal of Neuroradiology Mar 2019, DOI: 10.3174/ajnr.A6020

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Convolutional Neural Network–Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury

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