Article Figures & Data
Figures
- FIG 1.
Brain MR imaging pathologic features of CAA pathology. A, Axial T2* image from a 76-year-old male patient shows left frontal cortical siderosis and multiple foci of microhemorrhages of the predominant frontal location bilaterally. B, Axial T2 FLAIR image from a 73-year-old woman shows centrum semiovale white matter T2-hyperintense lesions attributed to chronic small-vessel ischemia. C, Axial T2 image from a 78-year-old female patient shows EPVS in the centrum semiovale.
- FIG 2.
Regional brain atrophy as measured by the visual rating score compared across cognition levels: normal, MCI, dementia. The regions evaluated are the anterior cingulate (A), orbitofrontal (B), anterior temporal (C), frontoinsular (D), medial temporal (E), and posterior (F) . Statistical significance is considered at P values < .05 (asterisk). CN indicates cognitively unimpaired; Dem, dementia; ns, not significant.
- FIG 3.
MTA as measured by the visual rating scale across dementia groups and sex: Male no Dem; Female no Dem; Male Dem; Female Dem. Statistical significance is considered at P values < .05. Dem indicates dementia.
- FIG 4.
Determinants of MTA in CAA. A, MTA as measured by visual rating across the presence (1) or absence (0) of cSS. B, Spearman correlation analysis of MTA with basal ganglia age-related white matter changes (BG ARWMC). C, Spearman correlation analysis of MTA with centrum semiovale age-related white matter changes (CS ARWMC). Statistical significance is considered at P values < .05 (asterisk). MT indicates medial temporal lobe.
- FIG 5.
EPVS across cognition groups. A, Basal ganglia EPVS. B, Centrum semiovale EPVS. C, Centrum semiovale EPVS across dementia by sex groups. Statistical significance is considered at P values < .05 (asterisk). CN indicates cognitively unimpaired; Dem, dementia; ns, not significant.
