Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

Sex-Specific Patterns of Cerebral Atrophy and Enlarged Perivascular Spaces in Patients with Cerebral Amyloid Angiopathy and Dementia

J. Pinho, F.C. Almeida, J.M. Araújo, Á. Machado, A.S. Costa, F. Silva, A. Francisco, M. Quintas-Neves, C. Ferreira, J.P. Soares-Fernandes and T.G. Oliveira
American Journal of Neuroradiology June 2023, DOI: https://doi.org/10.3174/ajnr.A7900
J. Pinho
aFrom the Department of Neurology (J.P., A.S.C.), University Hospital RWTH Aachen, Aachen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Pinho
F.C. Almeida
bLife and Health Sciences Research Institute (F.C.A., M.Q.-N., T.G.O.), School of Medicine
dLife and Health Sciences Research Institute/3Bs (F.C.A., M.Q.-N., T.G.O.), Portuguese Government Associate Laboratory, Braga/Guimarães, Portugal
eDepartment of Neuroradiology (F.C.A.), Centro Hospitalar Universitário do Porto, Porto, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.M. Araújo
fDepartments of Neurology (J.M.A., Á.M., C.F.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Á. Machado
fDepartments of Neurology (J.M.A., Á.M., C.F.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A.S. Costa
aFrom the Department of Neurology (J.P., A.S.C.), University Hospital RWTH Aachen, Aachen, Germany
hJARA Institute Molecular Neuroscience and Neuroimaging (A.S.C.), Forschungszentrum Jülich and RWTH Aachen University, Aachen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.S. Costa
F. Silva
cAlgoritmi Center (F.S., A.F.), University of Minho, Braga, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Francisco
cAlgoritmi Center (F.S., A.F.), University of Minho, Braga, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Quintas-Neves
bLife and Health Sciences Research Institute (F.C.A., M.Q.-N., T.G.O.), School of Medicine
dLife and Health Sciences Research Institute/3Bs (F.C.A., M.Q.-N., T.G.O.), Portuguese Government Associate Laboratory, Braga/Guimarães, Portugal
gNeuroradiology (M.Q.-N., J.P.S.-F., T.G.O.), Hospital de Braga, Braga, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Quintas-Neves
C. Ferreira
fDepartments of Neurology (J.M.A., Á.M., C.F.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.P. Soares-Fernandes
gNeuroradiology (M.Q.-N., J.P.S.-F., T.G.O.), Hospital de Braga, Braga, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T.G. Oliveira
bLife and Health Sciences Research Institute (F.C.A., M.Q.-N., T.G.O.), School of Medicine
dLife and Health Sciences Research Institute/3Bs (F.C.A., M.Q.-N., T.G.O.), Portuguese Government Associate Laboratory, Braga/Guimarães, Portugal
gNeuroradiology (M.Q.-N., J.P.S.-F., T.G.O.), Hospital de Braga, Braga, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T.G. Oliveira
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Greenberg SM,
    2. Bacskai BJ,
    3. Hernandez-Guillamon M, et al
    . Cerebral amyloid angiopathy and Alzheimer disease: one peptide, two pathways. Nat Rev Neurol 2020;16:30–42 doi:10.1038/s41582-019-0281-2 pmid:31827267
    CrossRefPubMed
  2. 2.↵
    1. Greenberg SM,
    2. Charidimou A
    . Diagnosis of cerebral amyloid angiopathy: evolution of the Boston criteria. Stroke 2018;49:491–97 doi:10.1161/STROKEAHA.117.016990 pmid:29335334
    FREE Full Text
  3. 3.↵
    1. Charidimou A,
    2. Boulouis G,
    3. Frosch MP, et al
    . The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study. Lancet Neurol 2022;21:714–25 doi:10.1016/S1474-4422(22)00208-3 pmid:35841910
    CrossRefPubMed
  4. 4.↵
    1. Subotic A,
    2. McCreary CR,
    3. Saad F, et al
    . Cortical thickness and its association with clinical cognitive and neuroimaging markers in cerebral amyloid angiopathy. J Alzheimers Dis 2021;81:1663–71 doi:10.3233/JAD-210138 pmid:33998545
    CrossRefPubMed
  5. 5.↵
    1. Fotiadis P,
    2. van Rooden S,
    3. van der Grond J, et al
    ; Alzheimer’s Disease Neuroimaging Initiative. Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study. Lancet Neurol 2016;15:811–19 doi:10.1016/S1474-4422(16)30030-8 pmid:27180034
    CrossRefPubMed
  6. 6.↵
    1. Attems J,
    2. Jellinger KA,
    3. Lintner F
    . Alzheimer’s disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy. Acta Neuropathol 2005;110:222–31 doi:10.1007/s00401-005-1064-y pmid:16133541
    CrossRefPubMed
  7. 7.↵
    1. Pfeifer LA,
    2. White LR,
    3. Ross GW, et al
    . Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study. Neurology 2002;58:1629–34 doi:10.1212/wnl.58.11.1629 pmid:12058090
    CrossRefPubMed
  8. 8.↵
    1. Boyle PA,
    2. Yu L,
    3. Nag S, et al
    . Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons. Neurology 2015;85:1930–36 doi:10.1212/WNL.0000000000002175 pmid:26537052
    Abstract/FREE Full Text
  9. 9.↵
    1. Xiong L,
    2. Davidsdottir S,
    3. Reijmer YD, et al
    . Cognitive profile and its association with neuroimaging markers of non-demented cerebral amyloid angiopathy patients in a stroke unit. J Alzheimers Dis 2016;52:171–78 doi:10.3233/JAD-150890 pmid:27060947
    CrossRefPubMed
  10. 10.↵
    1. Moulin S,
    2. Labreuche J,
    3. Bombois S, et al
    . Dementia risk after spontaneous intracerebral haemorrhage: a prospective cohort study. Lancet Neurol 2016;15:820–29 doi:10.1016/S1474-4422(16)00130-7 pmid:27133238
    CrossRefPubMed
  11. 11.↵
    1. Case NF,
    2. Charlton A,
    3. Zwiers A, et al
    . Cerebral amyloid angiopathy is associated with executive dysfunction and mild cognitive impairment. Stroke 2016;47:2010–16 doi:10.1161/STROKEAHA.116.012999 pmid:27338926
    Abstract/FREE Full Text
  12. 12.↵
    1. Costa AS,
    2. Pinho J,
    3. Kučikienė D, et al
    . Cerebral amyloid angiopathy in amyloid-positive patients from a memory clinic cohort. J Alzheimers Dis 2021;79:1661–72 doi:10.3233/JAD-201218 pmid:33492291
    CrossRefPubMed
  13. 13.↵
    1. Shinohara M,
    2. Murray ME,
    3. Frank RD, et al
    . Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease. Acta Neuropathol 2016;132:225–34 doi:10.1007/s00401-016-1580-y pmid:27179972
    CrossRefPubMed
  14. 14.↵
    1. Perosa V,
    2. Oltmer J,
    3. Munting LP, et al
    . Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex. Acta Neuropathol 2022;143:331–48 doi:10.1007/s00401-021-02393-1 pmid:34928427
    CrossRefPubMed
  15. 15.↵
    1. Tsai HH,
    2. Pasi M,
    3. Tsai LK, et al
    . Centrum semiovale perivascular space and amyloid deposition in spontaneous intracerebral hemorrhage. Stroke 2021;52:2356–62 doi:10.1161/STROKEAHA.120.032139 pmid:33874751
    CrossRefPubMed
  16. 16.↵
    1. Bouvy WH,
    2. van Veluw SJ,
    3. Kuijf HJ, et al
    ; Utrecht Vascular Cognitive Impairment (VCI) Study Group. Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer’s disease: A 7 Tesla MRI study. J Cereb Blood Flow Metab 2020;40:739–46 doi:10.1177/0271678X19838087 pmid:30890076
    CrossRefPubMed
  17. 17.↵
    1. Charidimou A,
    2. Boulouis G,
    3. Pasi M, et al
    . MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy. Neurology 2017;88:1157–64 doi:10.1212/WNL.0000000000003746 pmid:28228568
    Abstract/FREE Full Text
  18. 18.↵
    1. Charidimou A,
    2. Meegahage R,
    3. Fox Z, et al
    . Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study. J Neurol Neurosurg Psychiatry 2013;84:624–29 doi:10.1136/jnnp-2012-304434 pmid:23412074
    Abstract/FREE Full Text
  19. 19.↵
    1. Albert MS,
    2. DeKosky ST,
    3. Dickson D, et al
    . The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:270–79 doi:10.1016/j.jalz.2011.03.008 pmid:21514249
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Morris JC,
    2. Edland S,
    3. Clark C, et al
    . The consortium to establish a registry for Alzheimer's disease (CERAD), Part IV: rates of cognitive change in the longitudinal assessment of probable Alzheimer’s disease. Neurology 1993;43:2457–65 doi:10.1212/wnl.43.12.2457 pmid:8255439
    Abstract/FREE Full Text
  21. 21.↵
    1. Wahlund LO,
    2. Barkhof F,
    3. Fazekas F, et al
    . A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke 2001;32:1318–22 doi:10.1161/01.str.32.6.1318 pmid:11387493
    Abstract/FREE Full Text
  22. 22.↵
    1. Potter GM,
    2. Chappell FM,
    3. Morris Z, et al
    . Cerebral perivascular spaces visible on magnetic resonance imaging: development of a qualitative rating scale and its observer reliability. Cerebrovasc Dis 2015;39:224–31 doi:10.1159/000375153 pmid:25823458
    CrossRefPubMed
  23. 23.↵
    1. Harper L,
    2. Fumagalli GG,
    3. Barkhof F, et al
    . MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases. Brain 2016;139:1211–25 doi:10.1093/brain/aww005 pmid:26936938
    CrossRefPubMed
  24. 24.↵
    1. Brenowitz WD,
    2. Nelson PT,
    3. Besser LM, et al
    . Cerebral amyloid angiopathy and its co-occurrence with Alzheimer’s disease and other cerebrovascular neuropathologic changes. Neurobiol Aging 2015;36:2702–08 doi:10.1016/j.neurobiolaging.2015.06.028 pmid:26239176
    CrossRefPubMed
  25. 25.↵
    1. Xiong L,
    2. Boulouis G,
    3. Charidimou A, et al
    . Dementia incidence and predictors in cerebral amyloid angiopathy patients without intracerebral hemorrhage. J Cereb Blood Flow Metab 2018;38:241–49 doi:10.1177/0271678X17700435 pmid:28318355
    CrossRefPubMed
  26. 26.↵
    1. Koemans EA,
    2. Castello JP,
    3. Rasing I, et al
    . Sex differences in onset and progression of cerebral amyloid angiopathy. Stroke 2023;54:306–14 doi:10.1161/STROKEAHA.122.040823 pmid:36689586
    CrossRefPubMed
  27. 27.↵
    1. Gouveia-Freitas K,
    2. Bastos-Leite AJ
    . Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology. Neuroradiology 2021;63:1581–97 doi:10.1007/s00234-021-02718-7 pmid:34019111
    CrossRefPubMed
  28. 28.↵
    1. Jeong SH,
    2. Cha J,
    3. Park M, et al
    . Association of enlarged perivascular spaces with amyloid burden and cognitive decline in Alzheimer disease continuum. Neurology 2022 Aug 19. [Epub ahead of print] doi:10.1212/WNL.0000000000200989 pmid:35985826
    CrossRefPubMed
  29. 29.↵
    1. Charidimou A,
    2. Jäger RH,
    3. Peeters A, et al
    . White matter perivascular spaces are related to cortical superficial siderosis in cerebral amyloid angiopathy. Stroke 2014;45:2930–35 doi:10.1161/STROKEAHA.114.005568 pmid:25116879
    Abstract/FREE Full Text
  30. 30.↵
    1. Ingala S,
    2. van Maurik IS,
    3. Altomare D, et al
    . Clinical applicability of quantitative atrophy measures on MRI in patients suspected of Alzheimer’s disease. Eur Radiol 2022;32:7789–99 doi:10.1007/s00330-021-08503-7 pmid:35639148
    CrossRefPubMed
  31. 31.↵
    1. Wahlund LO,
    2. Julin P,
    3. Johansson SE, et al
    . Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging in dementia: a comparative study. J Neurol Neurosurg Psychiatry 2000;69:630–35 doi:10.1136/jnnp.69.5.630 pmid:11032615
    Abstract/FREE Full Text
  32. 32.↵
    1. Ferreira D,
    2. Cavallin L,
    3. Granberg T, et al
    ; AddNeuroMed Consortium and for the Alzheimer’s Disease Neuroimaging Initiative. Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition. Eur Radiol 2016;26:2597–610 doi:10.1007/s00330-015-4101-9 pmid:26560730
    CrossRefPubMed
  33. 33.↵
    1. Barisano G,
    2. Lynch KM,
    3. Sibilia F, et al
    . Imaging perivascular space structure and function using brain MRI. Neuroimage 2022;257:119329 doi:10.1016/j.neuroimage.2022.119329 pmid:35609770
    CrossRefPubMed
  34. 34.↵
    1. Chesebro AG,
    2. Amarante E,
    3. Lao PJ, et al
    . Automated detection of cerebral microbleeds on T2*-weighted MRI. Sci Rep 2021;11:4004 doi:10.1038/s41598-021-83607-0 pmid:33597663
    CrossRefPubMed
  35. 35.↵
    1. Schmidt P,
    2. Gaser C,
    3. Arsic M, et al
    . An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis. Neuroimage 2012;59:3774–83 doi:10.1016/j.neuroimage.2011.11.032 pmid:22119648
    CrossRefPubMed
  36. 36.↵
    1. Griffanti L,
    2. Zamboni G,
    3. Khan A, et al
    . BIANCA (Brain Intensity AbNormality Classification Algorithm): a new tool for automated segmentation of white matter hyperintensities. Neuroimage 2016;141:191–205 doi:10.1016/j.neuroimage.2016.07.018 pmid:27402600
    CrossRefPubMed
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Sex-Specific Patterns of Cerebral Atrophy and Enlarged Perivascular Spaces in Patients with Cerebral Amyloid Angiopathy and Dementia
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
J. Pinho, F.C. Almeida, J.M. Araújo, Á. Machado, A.S. Costa, F. Silva, A. Francisco, M. Quintas-Neves, C. Ferreira, J.P. Soares-Fernandes, T.G. Oliveira
Sex-Specific Patterns of Cerebral Atrophy and Enlarged Perivascular Spaces in Patients with Cerebral Amyloid Angiopathy and Dementia
American Journal of Neuroradiology Jun 2023, DOI: 10.3174/ajnr.A7900

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Sex-Specific Patterns of Cerebral Atrophy and Enlarged Perivascular Spaces in Patients with Cerebral Amyloid Angiopathy and Dementia
J. Pinho, F.C. Almeida, J.M. Araújo, Á. Machado, A.S. Costa, F. Silva, A. Francisco, M. Quintas-Neves, C. Ferreira, J.P. Soares-Fernandes, T.G. Oliveira
American Journal of Neuroradiology Jun 2023, DOI: 10.3174/ajnr.A7900
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • MR Imaging Findings in Anti-Leucine-Rich Glioma Inactivated Protein 1 Encephalitis: A Systematic Review and Meta-analysis
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire