Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN TUMOR IMAGING

Differentiating Low-Grade from High-Grade Intracranial Ependymomas: Comparison of Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging

Julio Arevalo-Perez, Elena Yllera-Contreras, Kyung K. Peck, Vaios Hatzoglou, Onur Yildirim, Marc K. Rosenblum and Andrei I. Holodny
American Journal of Neuroradiology May 2024, DOI: https://doi.org/10.3174/ajnr.A8226
Julio Arevalo-Perez
aFrom the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Julio Arevalo-Perez
Elena Yllera-Contreras
aFrom the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Elena Yllera-Contreras
Kyung K. Peck
bDepartment of Medical Physics (K.K.P.), Memorial Sloan Kettering Cancer Center, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kyung K. Peck
Vaios Hatzoglou
aFrom the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Onur Yildirim
aFrom the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Onur Yildirim
Marc K. Rosenblum
cDepartment of Pathology (M.K.R.), Memorial Sloan Kettering Cancer Center, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrei I. Holodny
aFrom the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Andrei I. Holodny
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Lombardi G,
    2. Della Puppa A,
    3. Pizzi M, et al
    . An overview of intracranial ependymomas in adults. Cancers (Basel) 2021;13:6128 doi:10.3390/cancers13236128 pmid:34885237
    CrossRefPubMed
  2. 2.↵
    1. Louis DN,
    2. Perry A,
    3. Reifenberger G, et al
    . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 2016;131:803–20 doi:10.1007/s00401-016-1545-1 pmid:27157931
    CrossRefPubMed
  3. 3.↵
    1. Xing Z,
    2. Zhou X,
    3. Xiao Z, et al
    . Comparison of conventional, diffusion, and perfusion MRI between low-grade and anaplastic extraventricular ependymoma. AJR Am J Roentgenol 2020;215:978–84 doi:10.2214/AJR.20.22764 pmid:32809860
    CrossRefPubMed
  4. 4.↵
    1. Shuangshoti S,
    2. Rushing EJ,
    3. Mena H, et al
    . Supratentorial extraventricular ependymal neoplasms: a clinicopathologic study of 32 patients. Cancer 2005;103:2598–605 doi:10.1002/cncr.21111 pmid:15861411
    CrossRefPubMed
  5. 5.↵
    1. Sun S,
    2. Wang J,
    3. Zhu M, et al
    . Clinical, radiological, and histological features and treatment outcomes of supratentorial extraventricular ependymoma: 14 cases from a single center. J Neurosurg 2018;128:1396–402 doi:10.3171/2017.1.JNS161422 pmid:28686116
    CrossRefPubMed
  6. 6.↵
    1. Oya N,
    2. Shibamoto Y,
    3. Nagata Y, et al
    . Postoperative radiotherapy for intracranial ependymoma: analysis of prognostic factors and patterns of failure. J Neurooncol 2002;56:87–94 doi:10.1023/a:1014442106111 pmid:11949831
    CrossRefPubMed
  7. 7.↵
    1. Xianwang L,
    2. Lei H,
    3. Hong L, et al
    . Apparent diffusion coefficient to evaluate adult intracranial ependymomas: relationship to Ki-67 proliferation index. J Neuroimaging 2021;31:132–36 doi:10.1111/jon.12789 pmid:32961009
    CrossRefPubMed
  8. 8.↵
    1. Gupta PK,
    2. Saini J,
    3. Sahoo P, et al
    . Role of dynamic contrast-enhanced perfusion magnetic resonance imaging in grading of pediatric brain tumors on 3T. Pediatr Neurosurg 2017;52:298–305 doi:10.1159/000479283 pmid:28848203
    CrossRefPubMed
  9. 9.↵
    1. Arevalo-Perez J,
    2. Peck KK,
    3. Young RJ, et al
    . Dynamic contrast-enhanced perfusion MRI and diffusion-weighted imaging in grading of gliomas. J Neuroimaging 2015;25:792–98 doi:10.1111/jon.12239 pmid:25867683
    CrossRefPubMed
  10. 10.↵
    1. Vajapeyam S,
    2. Brown D,
    3. Johnston PR, et al
    . Multiparametric analysis of permeability and ADC histogram metrics for classification of pediatric brain tumors by tumor grade. AJNR Am J Neuroradiol 2018;39:552–57 doi:10.3174/ajnr.A5502 pmid:29301780
    Abstract/FREE Full Text
  11. 11.↵
    1. Nam JG,
    2. Kang KM,
    3. Choi SH, et al
    . Comparison between the prebolus T1 measurement and the fixed T1 value in dynamic contrast-enhanced MR imaging for the differentiation of true progression from pseudoprogression in glioblastoma treated with concurrent radiation therapy and temozolomide chemotherapy. AJNR Am J Neuroradiol 2017;38:2243–50 doi:10.3174/ajnr.A5417 pmid:29074633
    Abstract/FREE Full Text
  12. 12.↵
    1. Conte GM,
    2. Altabella L,
    3. Castellano A, et al
    . Comparison of T1 mapping and fixed T1 method for dynamic contrast-enhanced MRI perfusion in brain gliomas. Eur Radiol 2019;29:3467–79 doi:10.1007/s00330-019-06122-x pmid:30972545
    CrossRefPubMed
  13. 13.↵
    1. Tofts PS,
    2. Brix G,
    3. Buckley DL, et al
    . Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 1999;10:223–32 doi:10.1002/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S pmid:10508281
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Hilario A,
    2. Ramos A,
    3. Perez-Nunez A, et al
    . The added value of apparent diffusion coefficient to cerebral blood volume in the preoperative grading of diffuse gliomas. AJNR Am J Neuroradiol 2012;33:701–07 doi:10.3174/ajnr.A2846 pmid:22207304
    Abstract/FREE Full Text
  15. 15.↵
    1. Santarosa C,
    2. Castellano A,
    3. Conte GM, et al
    . Dynamic contrast-enhanced and dynamic susceptibility contrast perfusion MR imaging for glioma grading: preliminary comparison of vessel compartment and permeability parameters using hotspot and histogram analysis. Eur J Radiology 2016;85:1147–56 doi:10.1016/j.ejrad.2016.03.020 pmid:27161065
    CrossRefPubMed
  16. 16.↵
    1. Calli C,
    2. Kitis O,
    3. Yunten N, et al
    . Perfusion and diffusion MR imaging in enhancing malignant cerebral tumors. Eur J Radiol 2006;58:394–403 doi:10.1016/j.ejrad.2005.12.032 pmid:16527438
    CrossRefPubMed
  17. 17.↵
    1. Kono K,
    2. Inoue Y,
    3. Nakayama K, et al
    . The role of diffusion-weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol 2001;22:1081–88 pmid:11415902
    PubMedWeb of Science
  18. 18.↵
    1. Lee EJ,
    2. Lee SK,
    3. Agid R, et al
    . Preoperative grading of presumptive low-grade astrocytomas on MR imaging: diagnostic value of minimum apparent diffusion coefficient. AJNR Am J Neuroradiol 2008;29:1872–77 doi:10.3174/ajnr.A1254 pmid:18719036
    CrossRefPubMed
  19. 19.↵
    1. Kim HS,
    2. Kim SY
    . A prospective study on the added value of pulsed arterial spin-labeling and apparent diffusion coefficients in the grading of gliomas. AJNR Am J Neuroradiol 2007;28:1693–99 doi:10.3174/ajnr.A0674 pmid:17885229
    CrossRefPubMed
  20. 20.↵
    1. Vajapeyam S,
    2. Stamoulis C,
    3. Ricci K, et al
    . Automated processing of dynamic contrast-enhanced MRI: correlation of advanced pharmacokinetic metrics with tumor grade in pediatric brain tumors. AJNR Am J Neuroradiol 2017;38:170–75 doi:10.3174/ajnr.A4949 pmid:27633807
    Abstract/FREE Full Text
  21. 21.↵
    1. Cha S,
    2. Johnson G,
    3. Wadghiri YZ, et al
    . Dynamic, contrast-enhanced perfusion MRI in mouse gliomas: correlation with histopathology. Magn Reson Med 2003;49:848–55 doi:10.1002/mrm.10446 pmid:12704767
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Maia AC, Jr.,
    2. Malheiros SM,
    3. da Rocha AJ, et al
    . MR cerebral blood volume maps correlated with vascular endothelial growth factor expression and tumor grade in nonenhancing gliomas. AJNR Am J Neuroradiol 2005;26:777–83 pmid:15814920
    PubMedWeb of Science
  23. 23.↵
    1. Aronen HJ,
    2. Gazit IE,
    3. Louis DN, et al
    . Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology 1994;191:41–51 doi:10.1148/radiology.191.1.8134596 pmid:8134596
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Aronen HJ,
    2. Pardo FS,
    3. Kennedy DN, et al
    . High microvascular blood volume is associated with high glucose uptake and tumor angiogenesis in human gliomas. Clin Cancer Res 2000;6:2189–200 pmid:10873068
    Abstract/FREE Full Text
  25. 25.↵
    1. Sugahara T,
    2. Korogi Y,
    3. Kochi M, et al
    . Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas. AJR Am J Roentgenol 1998;171:1479–86 doi:10.2214/ajr.171.6.9843274 pmid:9843274
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Arevalo-Perez J,
    2. Kebede AA,
    3. Peck KK, et al
    . Dynamic contrast-enhanced MRI in low-grade versus anaplastic oligodendrogliomas. J Neuroimaging 2016;26:366–71 doi:10.1111/jon.12320 pmid:26707628
    CrossRefPubMed
  27. 27.↵
    1. Wu J,
    2. Armstrong TS,
    3. Gilbert MR
    . Biology and management of ependymomas. Neuro Oncol 2016;18:902–13 doi:10.1093/neuonc/now016 pmid:27022130
    CrossRefPubMed
  28. 28.↵
    1. Ellingson BM,
    2. Zaw T,
    3. Cloughesy TF, et al
    . Comparison between intensity normalization techniques for dynamic susceptibility contrast (DSC)-MRI estimates of cerebral blood volume (CBV) in human gliomas. J Magn Reson Imaging 2012;35:1472–77 doi:10.1002/jmri.23600 pmid:22281731
    CrossRefPubMed
  29. 29.↵
    1. Boxerman JL,
    2. Schmainda KM,
    3. Weisskoff RM
    . Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. AJNR Am J Neuroradiol 2006;27:859–67 pmid:16611779
    PubMedWeb of Science
  30. 30.↵
    1. Boxerman JL,
    2. Prah DE,
    3. Paulson ES, et al
    . The role of preload and leakage correction in gadolinium-based cerebral blood volume estimation determined by comparison with MION as a criterion standard. AJNR Am J Neuroradiol 2012;33:1081–87 doi:10.3174/ajnr.A2934 pmid:22322605
    Abstract/FREE Full Text
  31. 31.↵
    1. Hacklander T,
    2. Reichenbach JR,
    3. Modder U
    . Comparison of cerebral blood volume measurements using the T1 and T2* methods in normal human brains and brain tumors. J Comput Assist Tomogr 1997;21:857–66 doi:10.1097/00004728-199711000-00003 pmid:9386273
    CrossRefPubMed
  32. 32.↵
    1. Lee J,
    2. Choi SH,
    3. Kim JH, et al
    . Glioma grading using apparent diffusion coefficient map: application of histogram analysis based on automatic segmentation. NMR Biomed 2014;27:1046–52 doi:10.1002/nbm.3153 pmid:25042540
    CrossRefPubMed
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Differentiating Low-Grade from High-Grade Intracranial Ependymomas: Comparison of Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Julio Arevalo-Perez, Elena Yllera-Contreras, Kyung K. Peck, Vaios Hatzoglou, Onur Yildirim, Marc K. Rosenblum, Andrei I. Holodny
Differentiating Low-Grade from High-Grade Intracranial Ependymomas: Comparison of Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging
American Journal of Neuroradiology May 2024, DOI: 10.3174/ajnr.A8226

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Differentiating Low-Grade from High-Grade Intracranial Ependymomas: Comparison of Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging
Julio Arevalo-Perez, Elena Yllera-Contreras, Kyung K. Peck, Vaios Hatzoglou, Onur Yildirim, Marc K. Rosenblum, Andrei I. Holodny
American Journal of Neuroradiology May 2024, DOI: 10.3174/ajnr.A8226
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Brain Tumor Subtyping Image-Based search via MRI
  • Neuroimaging of Erdheim-Chester Disease
  • CE MRI for Brain Metastasis Detection
Show more Brain Tumor Imaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire