- Multisite Benchmark Study for Standardized Relative CBV in Untreated Brain Metastases Using the DSC-MRI Consensus Acquisition Protocol
This multisite study found that the consensus DSC-MRI acquisition protocol confirmed the utility of standardized rCBV (srCBV) to identify biologically active, treatment-naïve brain metastases as distinguished from normal-appearing white matter and GBM. The data demonstrated that brain metastases of different primary origins have srCBV values that in general are significantly greater than normal-appearing white matter but significantly lower than srCBV for GBM.
- AI-Generated Synthetic STIR of the Lumbar Spine from T1 and T2 MRI Sequences Trained with Open-Source Algorithms
This proof-of-concept investigation used open-source generative adversarial networks to create synthetic lumbar spine MRI STIR from T1 and T2 sequences. Evaluating radiologists found the synthetic volumes were of equal or better quality in 77% of test patients and demonstrated equivalent or decreased motion artifacts in 78% of test patients. The synthetic volumes had high positive predictive value (75%-100%) but lower sensitivity (0%-67%) for common pathologies. The results from this study are a promising first step toward expediting imaging protocols.
- Vestibular Schwannoma–Related Increased Labyrinthine Postgadolinium 3D-FLAIR Signal Intensity and Association with Hearing Impairment
Increased 3D-FLAIR postgadolinium signal intensity of the ipsilateral labyrinth associated with vestibular schwannoma was shown to be correlated with sensorineural hearing loss. The study found that measured intralabyrinthine signal is associated with greater degrees of sensorineural hearing loss on audiometry.
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