Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis

A.R. Manning; V. Letchuman; M.L. Martin; E. Gombos; T. Robert-Fitzgerald; Q. Cao; P. Raza; C.M. O’Donnell; B. Renner; L. Daboul; P. Rodrigues; M. Ramos; J. Derbyshire; C. Azevedo; A. Bar-Or; E. Caverzasi; P.A. Calabresi; B.A.C. Cree; L. Freeman; R.G. Henry; E.E. Longbrake; J. Oh; N. Papinutto; D. Pelletier; R.D. Samudralwar; S. Suthiphosuwan; M.K. Schindler; M. Bilello; J.W. Song; E.S. Sotirchos; N.L. Sicotte; O. Al-Louzi; A.J. Solomon; D.S. Reich; D. Ontaneda; P. Sati; R.T. Shinohara; the NAIMS Cooperative

doi:10.3174/ajnr.A8510

Research ArticleUltra-High-Field MRI/Imaging of Epilepsy/Demyelinating Diseases/Inflammation/Infection

Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis

A.R. Manning, V. Letchuman, M.L. Martin, E. Gombos, T. Robert-Fitzgerald, Q. Cao, P. Raza, C.M. O’Donnell, B. Renner, L. Daboul, P. Rodrigues, M. Ramos, J. Derbyshire, C. Azevedo, A. Bar-Or, E. Caverzasi, P.A. Calabresi, B.A.C. Cree, L. Freeman, R.G. Henry, E.E. Longbrake, J. Oh, N. Papinutto, D. Pelletier, R.D. Samudralwar, S. Suthiphosuwan, M.K. Schindler, M. Bilello, J.W. Song, E.S. Sotirchos, N.L. Sicotte, O. Al-Louzi, A.J. Solomon, D.S. Reich, D. Ontaneda, P. Sati, R.T. Shinohara and the NAIMS Cooperative

American Journal of Neuroradiology March 2025, 46 (3) 620-626; DOI: https://doi.org/10.3174/ajnr.A8510

A.R. Manning

aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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V. Letchuman

bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland

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M.L. Martin

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E. Gombos

cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California

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T. Robert-Fitzgerald

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Q. Cao

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P. Raza

dCleveland Clinic Lerner College of Medicine (P. Raza, L.D.), Cleveland, Ohio

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C.M. O’Donnell

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B. Renner

cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California

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L. Daboul

bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland

dCleveland Clinic Lerner College of Medicine (P. Raza, L.D.), Cleveland, Ohio

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P. Rodrigues

eQMENTA Inc. (P. Rodrigues, M.R.), Boston, Massachusetts

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M. Ramos

eQMENTA Inc. (P. Rodrigues, M.R.), Boston, Massachusetts

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J. Derbyshire

fSection on Functional Imaging Methods (J.D.), Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

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C. Azevedo

gDepartment of Neurology (C.A., D.P.), University of Southern California, Los Angeles, California

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A. Bar-Or

hDepartment of Neurology (A.B.-O., R.D.S., M.K.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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E. Caverzasi

i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California

jDepartment of Brain and Behavioral Sciences (E.C.), University of Pavia, Pavia, Italy; Neuroradiology Department, Advanced Imaging and Radiomics Center (E.C.), IRCCS Mondino Foundation, Pavia, Italy

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P.A. Calabresi

kDepartment of Neurology (P.A.C., E.S.S.), Johns Hopkins University, Baltimore, Maryland

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B.A.C. Cree

i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California

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L. Freeman

lDepartment of Neurology, Dell Medical School (L.F.), The University of Texas at Austin, Austin, Texas

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R.G. Henry

i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California

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E.E. Longbrake

mDepartment of Neurology (E.E.L.), Yale University, New Haven, Connecticut

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J. Oh

nDivision of Neurology (J.O.), Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Canada

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N. Papinutto

i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California

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D. Pelletier

gDepartment of Neurology (C.A., D.P.), University of Southern California, Los Angeles, California

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R.D. Samudralwar

hDepartment of Neurology (A.B.-O., R.D.S., M.K.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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S. Suthiphosuwan

oDepartment of Medical Imaging (S.S.), St. Michael’s Hospital, University of Toronto, Toronto, Canada

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M.K. Schindler

hDepartment of Neurology (A.B.-O., R.D.S., M.K.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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M. Bilello

pDepartment of Radiology (M.B., J.W.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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J.W. Song

pDepartment of Radiology (M.B., J.W.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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E.S. Sotirchos

kDepartment of Neurology (P.A.C., E.S.S.), Johns Hopkins University, Baltimore, Maryland

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N.L. Sicotte

cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California

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O. Al-Louzi

bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland

cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California

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A.J. Solomon

qDepartment of Neurological Sciences (A.J.S.), Larner College of Medicine at the University of Vermont, Burlington, Vermont

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D.S. Reich

bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland

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D. Ontaneda

rMellen Center for Multiple Sclerosis (D.O.), Cleveland Clinic, Cleveland, Ohio

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P. Sati

bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland

cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California

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R.T. Shinohara

sCenter for Biomedical Image Computing and Analytics (R.T.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis

American Journal of Neuroradiology Mar 2025, 46 (3) 620-626; DOI: 10.3174/ajnr.A8510

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Automated vs Manual Central Vein Sign in MS

American Journal of Neuroradiology Mar 2025, 46 (3) 620-626; DOI: 10.3174/ajnr.A8510

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