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Research ArticleBrain

A Longitudinal MR Study of the Presymptomatic Phase in a Patient with Clinically Definite Multiple Sclerosis

Giovanna Mastronardo, Maria A. Rocca, Giuseppe Iannucci, Clodoaldo Pereira and Massimo Filippi
American Journal of Neuroradiology July 1999, 20 (7) 1268-1272;
Giovanna Mastronardo
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Maria A. Rocca
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Giuseppe Iannucci
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Clodoaldo Pereira
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Massimo Filippi
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    Fig 1. Axial brain MR images of a patient with CDMS, obtained before the onset of clinical symptoms. On the proton density–weighted image (A), many periventricular and discrete white matter lesions are visible. Two of them enhance on the contrast-enhanced T1-weighted image (B)

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    fig 2.

    MT histograms of a patient with CDMS, obtained before the onset of clinical symptoms (gray line), and MT histograms of 10 healthy control volunteers (black line)

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    fig 3.

    Coronal MR images of the spinal cord of a patient with CDMS, obtained before the onset of clinical symptoms. On the proton density–weighted image (A), a small lesion is visible in the posterior part of the cord at C2–C3. This lesion enhances on the contrast-enhanced T1-weighted image (B).fig 4. Coronal T1-weighted MR image of the brain of a patient, obtained at the time of an acute optic neuritis when a diagnosis of CDMS was made. Enhancement is visible (arrow) in the intraorbital portion of the left optic nerve

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    TABLE 1:

    Numbers of enhancing and new lesions detected on dual-echo and post-contrast T1-weighted MR scans during the presymptomatic phase of a patient with CDMS

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    TABLE 2:

    Mean MT histogram-derived metrics from a patient with CDMS before the onset of clinical symptoms and from 10 healthy controls

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American Journal of Neuroradiology
Vol. 20, Issue 7
1 Jul 1999
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Cite this article
Giovanna Mastronardo, Maria A. Rocca, Giuseppe Iannucci, Clodoaldo Pereira, Massimo Filippi
A Longitudinal MR Study of the Presymptomatic Phase in a Patient with Clinically Definite Multiple Sclerosis
American Journal of Neuroradiology Jul 1999, 20 (7) 1268-1272;

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A Longitudinal MR Study of the Presymptomatic Phase in a Patient with Clinically Definite Multiple Sclerosis
Giovanna Mastronardo, Maria A. Rocca, Giuseppe Iannucci, Clodoaldo Pereira, Massimo Filippi
American Journal of Neuroradiology Jul 1999, 20 (7) 1268-1272;
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