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Research ArticleBrain

A Longitudinal MR Study of the Presymptomatic Phase in a Patient with Clinically Definite Multiple Sclerosis

Giovanna Mastronardo, Maria A. Rocca, Giuseppe Iannucci, Clodoaldo Pereira and Massimo Filippi
American Journal of Neuroradiology July 1999, 20 (7) 1268-1272;
Giovanna Mastronardo
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Maria A. Rocca
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Giuseppe Iannucci
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Clodoaldo Pereira
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Massimo Filippi
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References

  1. ↵
    Georgi W. Multiple sklerose. Pathologisch-anatomische befund multiple sklerose bei klinisch diagnostizierten krankheiten. Wochenschrift 1961;91:605-607
  2. Mackay RP, Hirano A. Forms of benign multiple sclerosis. Report of two “clinically silent” cases discovered at autopsy. Arch Neurol 1967;17:588-600
    CrossRefPubMedWeb of Science
  3. Moriaru M, Klatzow WF. Subclinical multiple sclerosis. J Neurol 1976;213:71-76
    CrossRefPubMedWeb of Science
  4. Gilbert JJ, Sadler M. Unsuspected multiple sclerosis. Arch Neurol 1983;40:533-536
    CrossRefPubMedWeb of Science
  5. Engell T. A clinical patho-anatomical study of clinically silent multiple sclerosis. Acta Neurol Scand 1989;79:428-430
    CrossRefPubMedWeb of Science
  6. ↵
    Morrissey SP, Miller DH, Kendall BE, et al. The significance of magnetic resonance imaging abnormalities at presentation with clinically isolated syndromes suggestive of MS. Brain 1993;116:135-146
    Abstract/FREE Full Text
  7. Filippi M, Horsfield MA, Morrissey SP, et al. Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis. Neurology 1994;44:635-641
    Abstract/FREE Full Text
  8. Miller DH, Albert PS, Barkhof F, et al. Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis. Ann Neurol 1996;39:6-16
    CrossRefPubMedWeb of Science
  9. ↵
    Thompson AJ, Polman CH, Miller DH, et al. Primary progressive multiple sclerosis. Brain 1997;120:1085-1096
    Abstract/FREE Full Text
  10. ↵
    Rao SM, Cognitive Function Study Group NMSS. A manual for the brief repeatable battery of neuropsychological tests in multiple sclerosis.. New York: National Multiple Sclerosis Society; 1990
  11. ↵
    Miller DH, Barkhof F, Berry I, Kappos L, Scotti G, Thompson AJ. Magnetic resonance imaging in monitoring the treatment of multiple sclerosis. Concerted action guidelines. J Neurol Neurosurg Psychiatry 1991;54:683-688
    Abstract/FREE Full Text
  12. ↵
    Filippi M, Yousry TA, Alkadhi H, Stehling M, Horsfield MA, Voltz R. Spinal cord MRI in multiple sclerosis with multicoil arrays. A comparison between fast spin echo and fast FLAIR. J Neurol Neurosurg Psychiatry 1996;61:632-635
    Abstract/FREE Full Text
  13. ↵
    Yousry TA, Filippi M, Becker C, Horsfield MA, Voltz R. Comparison of MR pulse sequences in the detection of multiple sclerosis lesions. AJNR Am J Neuroradiol 1997;18:959-963
    Abstract/FREE Full Text
  14. ↵
    Rovaris M, Filippi M, Calori G, et al. Intra-observer reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis. A comparison with conventional T2-weighted images. J Neurol 1997;244:266-270
    CrossRefPubMedWeb of Science
  15. ↵
    Rovaris M, Filippi M, Falautano M, et al. Relationship between brain MR abnormalities and patterns of cognitive impairment in patients with multiple sclerosis. Neurology 1998;50:1601-1608
    Abstract/FREE Full Text
  16. ↵
    Filippi M, Rocca MA, Rizzo G, et al. Magnetization transfer ratios in MS lesions enhancing after different doses of gadolinium-DTPA. Neurology 1998;50:1289-1293
    Abstract/FREE Full Text
  17. ↵
    van Buchem MA, McGowan JC, Kolson DL, Polansky M, Grossman RI. Quantitative volumetric magnetization transfer analysis in multiple sclerosis. Estimation of macroscopic and microscopic disease burden. Magn Reson Med 1996;36:632-636
    PubMedWeb of Science
  18. ↵
    Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis. Guidelines for research protocols. Ann Neurol 1983;13:227-231
    CrossRefPubMedWeb of Science
  19. ↵
    Paty DW, Oger JJF, Kastrukoff LF, et al. MRI in the diagnosis of MS. A perspective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT. Neurology 1988;38:180-185
    Abstract/FREE Full Text
  20. Fazekas F, Offenbacher H, Fuchs S, et al. Criteria for an increased specificity of MRI interpretation in elderly subjects with suspected multiple sclerosis. Neurology 1988;38:1822-1825
    Abstract/FREE Full Text
  21. Barkhof F, Filippi M, Miller DH, et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 1997;120:2059-2069
    Abstract/FREE Full Text
  22. ↵
    Campi A, Filippi M, Comi G, et al. Acute transverse myelopathy. Spinal and cranial MR study with clinical follow-up. AJNR Am J Neuroradiol 1995;16:115-123
    Abstract
  23. Tartaglino LM, Friedman DP, Flanders AE, Lublin FD, Knobler RL, Liem M. Multiple sclerosis in the spinal cord. MR appearance and correlations with clinical parameters. Radiology 1995;195:725-732
    PubMedWeb of Science
  24. ↵
    Thorpe JW, Kidd D, Moseley IF, et al. Serial gadolinium-enhanced MRI of the brain and spinal cord in early relapsing-remitting multiple sclerosis. Neurology 1996;46:373-378
    Abstract/FREE Full Text
  25. ↵
    Miller DH. Magnetic resonance in monitoring the treatment of multiple sclerosis. Ann Neurol 1994;36:S91-S94
  26. Filippi M, Rossi P, Campi A, Colombo B, Pereira C, Comi G. Serial contrast-enhanced MR in patients with multiple sclerosis and varying levels of disability. AJNR Am J Neuroradiol 1997;18:1549-1556
    Abstract
  27. McDonald WI, Miller DH, Barnes D. The pathological evolution of multiple sclerosis. Neuropathol Appl Neurobiol 1992;18:319-334
    PubMedWeb of Science
  28. ↵
    Filippi M, Sormani MP, Rovaris M, Comi G. How does brain MRI lesion volume change in patients with multiple sclerosis? Magn Reson Imaging 1998;16:1181-1183
    CrossRefPubMed
  29. ↵
    O'Riordan JI, Losseff NA, Phatouros C, et al. Asymptomatic spinal cord lesions in clinically isolated optic nerve, brain stem, and spinal cord syndromes suggestive of demyelination. J Neurol Neurosurg Psychiatry 1998;64:353-357
    Abstract/FREE Full Text
  30. ↵
    Barbosa S, Blumhardt LD, Roberts N, Lock T, Edwards RH. Magnetic resonance relaxation time mapping in multiple sclerosis. Normal appearing white matter and the “invisible” lesion load. Magn Reson Imaging 1994;12:33-42
    CrossRefPubMedWeb of Science
  31. ↵
    Filippi M, Campi A, Dousset V, et al. A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis. Neurology 1995;45:478-482
    Abstract/FREE Full Text
  32. Loevner LA, Grossman RI, Cohen JA, Lexa FJ, Kessler D, Kolson DL. Microscopic disease in normal-appearing white matter on conventional MR images in patients with multiple sclerosis. Assessment with magnetization-transfer measurements. Radiology 1995;96:511-515
  33. Fu L, Matthews PM, De Stefano N, et al. Imaging of axonal damage of normal appearing white matter in multiple sclerosis. Brain 1998;121:103-113
    Abstract/FREE Full Text
  34. ↵
    van Walderveen MAA, Kamphorst W, Scheltens P, et al. Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis. Neurology 1998;50:1282-1288
    Abstract/FREE Full Text
  35. Bruck W, Bitsch A, Kolenda H, et al. Inflammatory central nervous system demyelination. Correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 1997;42:783-793
    CrossRefPubMedWeb of Science
  36. Grossman RI. Magnetization transfer in multiple sclerosis. Ann Neurol 1994;36:S97-S99
  37. van Waesberghe JHTM, van Walderveen MAA, de Groot C, David R, Lycklama à Nijeholt GJ. Postmortem correlation between axonal loss, MTR, and hypointensity on T1 SE in MS. Proceedings of the International Society for Magnetic Resonance in Medicine 1998;2:1334
  38. ↵
    van Walderveen MAA, Barkhof F, Hommes OR, Brück Y, Stiefel M, Lassmann H. Correlating MRI and clinical disease activity in multiple sclerosis. Relevance of hypointense lesions on short TR/short TE (T1-weighted) spin-echo images. Neurology 1995;45:1684-1690
    Abstract/FREE Full Text
  39. Truyen L, van Waesberghe JHTM, van Walderveen MAA, et al. Accumulation of hypointense lesions (“black holes”) on T1 spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology 1996;47:1469-1476
    Abstract/FREE Full Text
  40. Filippi M, Rocca MA, Horsfield MA, et al. Increased spatial resolution using a three-dimensional T1-weighted gradient-echo MR sequence results in greater hypointense lesion volumes in multiple sclerosis. AJNR Am J Neuroradiol 1998;19:235-238
    Abstract
  41. ↵
    De Stefano N, Matthews PM, Narayanan S, Francis GS, Antel JP, Arnold DL. Axonal dysfunction and disability in a relapse of multiple sclerosis. Longitudinal study of a patient. Neurology 1997;49:1138-1141
    Abstract/FREE Full Text
  42. De Stefano N, Matthews PM, Fu L, et al. Axonal change correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain 1998;121:1469-1477
    Abstract/FREE Full Text
  43. ↵
    Moreau T, Coles A, Wing M, et al. Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis. Brain 1996;119:457-463
    Abstract/FREE Full Text
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Giovanna Mastronardo, Maria A. Rocca, Giuseppe Iannucci, Clodoaldo Pereira, Massimo Filippi
A Longitudinal MR Study of the Presymptomatic Phase in a Patient with Clinically Definite Multiple Sclerosis
American Journal of Neuroradiology Jul 1999, 20 (7) 1268-1272;

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A Longitudinal MR Study of the Presymptomatic Phase in a Patient with Clinically Definite Multiple Sclerosis
Giovanna Mastronardo, Maria A. Rocca, Giuseppe Iannucci, Clodoaldo Pereira, Massimo Filippi
American Journal of Neuroradiology Jul 1999, 20 (7) 1268-1272;
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