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Research ArticleBRAIN

Abnormal Perfusion of the Pituitary Gland Secondary to Dural Arteriovenous Fistulas in the Cavernous Sinus: Dynamic MR Findings

Yoshinori Shigematsu, Yukunori Korogi, Mika Kitajima, Akihiko Ishii, Luxia Liang, Masayuki Yamura, Kouich Kawanaka and Mutsumasa Takahashi
American Journal of Neuroradiology May 2003, 24 (5) 930-936;
Yoshinori Shigematsu
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Yukunori Korogi
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Mika Kitajima
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Akihiko Ishii
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Luxia Liang
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Masayuki Yamura
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Kouich Kawanaka
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Mutsumasa Takahashi
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  • Fig 1.
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    Fig 1.

    ROIs on a coronal dynamic image. The ROIs were located at the center and bilateral peripheral areas of the anterior pituitary gland for dynamic curve analyses.

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    Fig 2.

    Images in a 50-year-old woman with a dural AVF draining into the right cavernous sinus (case 7).

    A, Digital subtraction angiogram reveals the AVF draining into the right cavernous sinus.

    B–E, Pretreatment dynamic MR images. In phase 0 (B) and in the first (C), second (D), and third (E) phases, the enhancement of the right side of the pituitary gland is delayed (arrow in C–E).

    F–I, Posttreatment dynamic MR images in phase 0 (F) and in the first (G), second (H), and third (I) phases. After treatment of the disease, the pituitary gland is symmetrically enhancing on both the right and left sides, and the height of the pituitary gland decreased from 7 to 5 mm. Part of the posterior pituitary gland is seen as a hyperintense area in phase 0.

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    Fig 3.

    Dynamic curves in a 50-year-old woman with a dural AVF draining into the right cavernous sinus (case 7).

    A, Pretreatment dynamic curves. The three ROIs were located at the center and bilateral peripheral areas of the pituitary gland (Fig 1). On the right side of the pituitary gland, the peak of the enhancement was not found within the imaging time before treatment.

    B, Posttreatment dynamic curves. On the right side, the peak-enhanced phase was shortened and found within the 10 phases.

  • Fig 4.
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    Fig 4.

    Images in a 62-year-old woman with a dural AVF draining into the left cavernous sinus (case 6).

    A, Digital subtraction angiogram reveals the AVF draining into the left cavernous sinus.

    B–E, Pretreatment dynamic MR images of the anterior pituitary gland. In phase 0 (B) and in the first (C), second (D), and third (E) phases, the enhancement of the left side of the pituitary gland is delayed (arrow in C–E). In phase 0, the left cavernous sinus is already enhancing because of the AVFs, but no enhancement can be seen in the pituitary gland; this is why this image was defined as phase 0.

    F–I, Posttreatment dynamic MR images in phase 0 (F) and in the first (G), second (H), and third (I) phases. After treatment of the disease, the laterality of the enhancement on early dynamic images became less prominent, and the height of the pituitary gland decreased from 8 to 7 mm. In this case only, the laterality of the enhancement somewhat remained after treatment (arrow in G).

  • Fig 5.
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    Fig 5.

    Dynamic curves in a 62-year-old woman with a dural AVF draining into the left cavernous sinus (case 6).

    A, Pretreatment dynamic curves. The peaks of the dynamic curves were in phase 9 for the central area, phase 6 for the right side, and out of the imaging time for the left side.

    B, Posttreatment dynamic curves. The peaks of the dynamic curves are shortened at both the central and bilateral peripheral areas of the pituitary gland.

Tables

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    TABLE 1:

    Summary of patients with a dural AVF in the cavernous sinus

    Patient No./Age, y/SexFistula*Dilated Draining Vein*EmbolizationRadiation Therapy
    Cavernous Sinus Coil PackingExternal Carotid Artery
    1/68/FD/DSOV, CV/SOV, CVNoYesYes
    2/58/FD/–IPS/IPSYesYesYes
    3/68/FD/DIPS, SOV/IPS, SOVNoYesYes
    4/62/F–/DNone/SOVNoNoYes
    5/77/FD/DSOV, IPS/SOV, CVNoYesYes
    6/62/F–/DCV/SOV, SPS, CVYesYesNo
    7/50/FD/–SOV/noneYesYesNo
    8/69/FD/–SOV, IPS, SPS/noneYesYesNo
    9/62/FD/–SOV, SPS/noneYesYesNo
    • * Data are for the right side/left side. CV indicates cortical vein; IPS, inferior petrosal vein; SOV, superior ophthalmic vein; SPS, superior petrosal vein; D, type D fistula; –, no fistula.

    • View popup
    TABLE 2:

    Finding on dynamic MR images of the pituitary gland before and after therapy

    PatientSide of Fistula on AngiographyLaterality of Enhancement, Delayed SidePhase with Homogenous Enhancement*Height of Pituitary Gland, mm†
    Before TherapyAfter TherapyBefore TherapyAfter TherapyBefore TherapyAfter Therapy
    1BilateralNoneNone4433
    2RightNoneNone3373
    3BilateralLeftNone3294
    4LeftNoneNone3366
    5BilateralRightNone3244
    6LeftLeftLeft8587
    7RightRightNone>10875
    8RightNoneNone2266
    9RightRightNone6387
    • * Mean, 4.7 before therapy and 3.6 after therapy.

    • † Mean, 6.4 before therapy and 5.0 after therapy.

    • View popup
    TABLE 3:

    Peak enhancement phase on dynamic curves*

    GroupCenterPeriphery
    Patients before treatment6.0 ± 1.77.5 ± 2.5†
    Patients after treatment4.2 ± 2.65.4 ± 3.1
    Control subjects4.0 ± 1.44.2 ± 1.4
    • * Data are the mean ± SD.

    • † P < .01, compared with posttreatment and control values.

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American Journal of Neuroradiology: 24 (5)
American Journal of Neuroradiology
Vol. 24, Issue 5
1 May 2003
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Cite this article
Yoshinori Shigematsu, Yukunori Korogi, Mika Kitajima, Akihiko Ishii, Luxia Liang, Masayuki Yamura, Kouich Kawanaka, Mutsumasa Takahashi
Abnormal Perfusion of the Pituitary Gland Secondary to Dural Arteriovenous Fistulas in the Cavernous Sinus: Dynamic MR Findings
American Journal of Neuroradiology May 2003, 24 (5) 930-936;

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Abnormal Perfusion of the Pituitary Gland Secondary to Dural Arteriovenous Fistulas in the Cavernous Sinus: Dynamic MR Findings
Yoshinori Shigematsu, Yukunori Korogi, Mika Kitajima, Akihiko Ishii, Luxia Liang, Masayuki Yamura, Kouich Kawanaka, Mutsumasa Takahashi
American Journal of Neuroradiology May 2003, 24 (5) 930-936;
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