Article Figures & Data
Figures
- Fig 1
Images show region of interest placement for the posterior limb of the internal capsule. B0, image without diffusion weighting; DWI, diffusion-weighted image; FA, fractional anisotropy image; ADC, apparent diffusion coefficient map.
- Fig 2
Average FA histograms by clinical subgroup. N, normal neurologic outcome; AN abnormal neurologic outcome.
- Fig 3
Average ADC histograms by clinical subgroup. N, normal neurologic outcome; AN abnormal neurologic outcome.
Tables
GA ≤ 33 weeks Birthweight < 1800 g Initial population n = 137 Age at time of MR imaging, with 34–42 weeks 30 with incomplete follow-ups Outcome analysis n = 107 17 with category > 2 DTI population n = 90 27 with incomplete DTI DTI study group nc = 63 Note.—GA indicates gestational age; DTI, diffusion tensor imaging.
- TABLE 2:
Neurologic outcome and conventional MR imaging category for 63 infants fully studied
MR Imaging Category Normal AN 1 32 11 2 18 2 Note.—Normal indicates normal neurologic outcome; AN, abnormal neurologic outcome; Category 1, no abnormality; category 2, minimal subependymal hemorrhage or mineralization.
FA Mean SD Range P Value Corpus callosum genu N .449 .082 .255–.621 .98 AN .448 .078 .332–.580 Corpus callosum splenium N .451 .079 .273–.616 .16 AN .416 .075 .238–.519 Internal capsule anterior L N .259 .054 .153–.381 .14 AN .230 .026 .197–.267 Internal capsule anterior R N .267 .054 .148–.384 .91 AN .265 .079 .171–.411 Internal capsule posterior L N .397 .059 .280–.539 .08 AN .365 .049 .305–.488 Internal capsule posterior R N .411 .046 .284–.509 .0002 AN .351 .061 .259–.499 Cerebral white matter L N .188 .041 .028–.277 .13 AN .169 .030 .113–.208 Cerebral white matter R N .184 .033 .114–.290 .16 AN .170 .031 .120–.220 Note.—FA indicates fractional anisotropy; N, normal neurologic outcome; AN, abnormal neurologic outcome; L, left; R, right.
- TABLE 4:
Region of interest apparent diffusion coefficient (μ mm2/s) values by pooled clinical subgroup
ADC Mean SD Range P Value Corpus callosum genu N 1.312 .132 1.024–1.703 0.84 AN 1.320 .122 1.100–1.499 Corpus callosum splenium N 1.268 .145 1.050–2.055 0.09 AN 1.340 .071 1.211–1.461 Internal capsule anterior L N 1.216 .092 1.039–1.426 0.10 AN 1.122 .320 0.359–1.376 Internal capsule anterior R N 1.209 .108 1.001–1.429 0.33 AN 1.248 .088 1.126–1.363 Internal capsule posterior L N 1.095 .071 0.970–1.329 0.51 AN 1.080 .057 0.983–1.200 Internal capsule posterior R N 1.091 .075 0.893–1.289 0.92 AN 1.093 .068 0.965–1.208 Cerebral white matter L N 1.413 .117 1.186–1.687 0.23 AN 1.458 .130 1.287–1.741 Cerebral white matter R N 1.424 .134 1.205–1.818 0.20 AN 1.478 .135 1.274–1.736 Note.—ADC indicates apparent diffusion coefficient; N, normal neurologic outcome; AN, abnormal neurologic outcome; L, left; R, right.
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