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Paraplegia and Sensory Deficit Caused by Angiotropic Large Cell Lymphoma

Marc Legeais, Sophie Gallas, Jean Philippe Cottier and Denis Herbreteau
American Journal of Neuroradiology November 2004, 25 (10) 1831-1835;
Marc Legeais
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Sophie Gallas
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Jean Philippe Cottier
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Denis Herbreteau
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  • Fig 1.
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    Fig 1.

    Imaging findings at initial imaging.

    A, T2-weighted image shows a thick conus that is increased in signal intensity.

    B, Contrast-enhanced T1-weighted image shows a thick conus without enhancement.

  • Fig 2.
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    Fig 2.

    Imaging findings at 6-week follow-up.

    A, MR image shows an enlargement of the thoracic cord associated with increased signal intensity in T2-weighted images.

    B, The conus remains enlarged with signal intensity abnormality.

    C, Axial T2-weighted MR image shows a central signal intensity abnormality within the cord at the T12 level.

    D, There is still no enhancement of the conus following contrast medium injection.

  • Fig 3.
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    Fig 3.

    Imaging findings at 10-week follow-up.

    A, There is an extension of spinal cord thickening on T2-weighted images.

    B, Abnormal enhancement after Gd-DTPA injection on T1- weighted images.

    C, T2-weighted FLAIR weighted image shows appearance of a right temporal lesion.

    D, Postcontrast T1-weighted image shows lesion enhancement.

  • Fig 4.
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    Fig 4.

    Large tumor cells in the lumen of small vessels of the brain (magnification ×400; hematoxylin and eosin). Biopsy fragments were taken from the right temporal lobe.

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    Fig 5.

    Large intravascular tumor cells express the cluster of differentiation 20,which is specific for B-cell lineage lymphocyte. (magnification ×400) (method with autoantibodies immunofixation). Biopsy fragments were taken from the right temporal lobe.

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    Fig 6.

    Imaging findings at 20-week follow-up.

    A, T2-weighted FLAIR image following treatment shows disappearance of the previous signal intensity abnormality in the leptomeninges and in the right temporal lobe.

    B, Contrast-enhanced T1-weighted image shows disappearance of prior enhancement.

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    TABLE:

    The dates of examination, area examined, and the findings at each time interval.

    Initial Status6 Weeks Later10 Weeks Later20 Weeks Later
    Lumbar CordChemotherapy
        T2 Hyperintensity++++++−
        Enhancement−−++−
        Enlargement+++++
    Thoracic Cord
        T2 Hyperintensity+++++−
        Enhancement−−−−
        Enlargement−++++
    Cervical Cord
        T2 Hyperintensity+++++−
        Enhancement−−−−
        Enlargement−++++
    Brain
        T2 Hyperintensity(not performed)−+++ (toxic origin)
        Enhancement(not performed)−++−
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American Journal of Neuroradiology: 25 (10)
American Journal of Neuroradiology
Vol. 25, Issue 10
1 Nov 2004
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Cite this article
Marc Legeais, Sophie Gallas, Jean Philippe Cottier, Denis Herbreteau
Paraplegia and Sensory Deficit Caused by Angiotropic Large Cell Lymphoma
American Journal of Neuroradiology Nov 2004, 25 (10) 1831-1835;

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Paraplegia and Sensory Deficit Caused by Angiotropic Large Cell Lymphoma
Marc Legeais, Sophie Gallas, Jean Philippe Cottier, Denis Herbreteau
American Journal of Neuroradiology Nov 2004, 25 (10) 1831-1835;
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