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Line-Scan Diffusion Tensor Imaging of the Posttraumatic Brain Stem: Changes with Neuropathologic Correlation

K. Yen, J. Weis, R. Kreis, E. Aghayev, C. Jackowski, M. Thali, C. Boesch, S.E. Maier, R. Dirnhofer and K.O. Lövblad
American Journal of Neuroradiology January 2006, 27 (1) 70-73;
K. Yen
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J. Weis
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R. Kreis
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E. Aghayev
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C. Jackowski
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M. Thali
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C. Boesch
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S.E. Maier
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R. Dirnhofer
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    Fig 1.

    A, Diffusion tensors overlaid on T2 image in the patient with cervical trauma. Disorganization of the distal brain stem white matter tracts is present.

    B, Diffusion tensors overlaid on T2 image in the patient who died after cardiac arrest shows intact fibers with an overall slight wavy configuration.

    C, Diffusion tensors overlaid on T2 image in a healthy living volunteer showing the homogenous character of the craniocaudal brain stem white matter tracts.

    The principal eigenvector of the diffusion tensor scaled by the fractional anisotropy (FA) is represented by its projection onto the sagittal plane by using red dashes and by its through-plane component by using dots (yellow dot for strong component, blue dot for intermediate component, and missing dot for a weak component). For clarity, tensors were visualized in this figure at a lower resolution than measured, displaying a single vector for every 9 pixels of the interpolated image (ie, 1.5-times lower resolution in both dimensions than measured).

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    Fig 2.

    A, Sagittal T2-weighted image showing no visible changes in the brain stem tissue. The brain stem is partially dislocated following traumatic impact because of compression by the fractured clivus.

    B, Sagittal FA map showing an area of higher anisotropy at the level of the transition between the pons and medulla, likely due to hemorrhage at the pontomedullary junction, but noise contributions cannot be ruled out.

    C, Macroscopy: sagittal autopsy specimen showing punctate hemorrhagic changes and partially disrupted brain stem tissue at the level of the transition between pons and medulla

    D, Microscopy: histologic section of brain stem fiber tract demonstrating acute hemorrhage and edema (paraffin; H&E; scale bar = 60 μm). Axonal swellings indicating a prolonged interval between the traumatic lesion and death are absent due to the immediate death of the patient.

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American Journal of Neuroradiology: 27 (1)
American Journal of Neuroradiology
Vol. 27, Issue 1
January, 2006
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K. Yen, J. Weis, R. Kreis, E. Aghayev, C. Jackowski, M. Thali, C. Boesch, S.E. Maier, R. Dirnhofer, K.O. Lövblad
Line-Scan Diffusion Tensor Imaging of the Posttraumatic Brain Stem: Changes with Neuropathologic Correlation
American Journal of Neuroradiology Jan 2006, 27 (1) 70-73;

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Line-Scan Diffusion Tensor Imaging of the Posttraumatic Brain Stem: Changes with Neuropathologic Correlation
K. Yen, J. Weis, R. Kreis, E. Aghayev, C. Jackowski, M. Thali, C. Boesch, S.E. Maier, R. Dirnhofer, K.O. Lövblad
American Journal of Neuroradiology Jan 2006, 27 (1) 70-73;
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