Article Figures & Data
Figures
- Fig 1.
Diagram of a typical rosette demonstrating a halo of cells surrounding a central lumen. Adapted from Ellison et al (2004)34 with permission.
- Fig 2.
Example of a cathedral rose window. Photo courtesy of the Cathedral Basilica of St. Louis, used with permission.
- Fig 3.
Diagram of Homer Wright rosette. A halo of cells surrounds a central hub that contains a meshwork of fibers. Adapted from Ellison et al (2004)34 with permission.
- Fig 4.
Photomicrograph from a PNET demonstrating multiple Homer Wright rosettes. The halo-like cluster of cells in each rosette surrounds a central area of fiber-rich neuropil (H&E; original magnification 400×).
- Fig 5.
Diagram of Flexner-Wintersteiner rosette. A halo of cells surrounds a largely empty central hub. Small cytoplasmic extensions from the cells project into the lumen. Adapted from Ellison et al (2004)34 with permission.
- Fig 6.
Photomicrograph from a retinoblastoma showing multiple Flexner-Wintersteiner rosettes. The halo-like cluster of cells in each rosette surrounds a nearly empty appearing central lumen containing fine cytoplasmic processes (H&E; original magnification 400×). Photomicrograph generously donated by Dr. Morton Smith, Ophthalmic Pathology, Washington University, St. Louis.
- Fig 7.
Diagram of true ependymal rosette. A halo of cells surrounds an empty lumen. Adapted from Ellison et al (2004)34 with permission.
- Fig 8.
Photomicrograph from an ependymoma showing several true ependymal rosettes. The halo-like cluster of cells in each rosette surrounds an empty central lumen (H&E; original magnification 400×).
- Fig 9.
Diagram of perivascular pseudorosette. A halo of cells surrounds a blood vessel. Adapted from Ellison et al (2004)34 with permission.
- Fig 10.
Photomicrograph from an ependymoma showing 2 prominent perivascular pseudorosettes. The halo-like cluster of cells in each rosette surrounds a blood vessel. Note the several smaller true ependymal rosettes (H&E; original magnification 200×).
- Fig 11.
Diagram of neurocytic rosette. This rosette is similar to the Homer Wright rosette, but the central fiber-rich neuropil island is larger and more irregular. Adapted from Ellison et al (2004)34 with permission.
- Fig 12.
Photomicrograph from a central neurocytoma containing an irregularly shaped neurocytic rosette with central neuropil (H&E; original magnification 400×).
Tables
Summary of rosette patterns and associated tumors
Rosette Type Associated Tumors Homer Wright rosette Neuroblastoma, medulloblastoma, primitive neuroectodermal tumor, pineoblastoma Flexner-Wintersteiner rosette Retinoblastoma, pineoblastoma, medulloepithelioma True ependymal rosette Ependymoma Perivascular pseudorosette Ependymoma, medulloblastoma, primitive neuroectodermal tumor, central neurocytoma, glioblastoma, monomorphous pilomyxoid astrocytomas Pineocytomatous rosette Pineocytoma Neurocytic rosette Central neurocytoma
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