Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticleAdult Brain
Open Access

Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline

I.K. Martikainen, N. Kemppainen, J. Johansson, J. Teuho, S. Helin, Y. Liu, S. Helisalmi, H. Soininen, R. Parkkola, T. Ngandu, M. Kivipelto and J.O. Rinne
American Journal of Neuroradiology January 2019, 40 (1) 80-85; DOI: https://doi.org/10.3174/ajnr.A5891
I.K. Martikainen
aFrom the Department of Radiology (I.K.M.), Medical Imaging Center, Tampere University Hospital, Tampere, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for I.K. Martikainen
N. Kemppainen
bDivision of Clinical Neurosciences (N.K., J.O.R.), Turku University Hospital, Turku, Finland
cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Kemppainen
J. Johansson
cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Johansson
J. Teuho
cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Teuho
S. Helin
cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Helin
Y. Liu
dDepartment of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland
eNeurocenter (Y.L., H.S., M.K.), Neurology, Kuopio University Hospital, Kuopio, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y. Liu
S. Helisalmi
dDepartment of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Helisalmi
H. Soininen
dDepartment of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland
eNeurocenter (Y.L., H.S., M.K.), Neurology, Kuopio University Hospital, Kuopio, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for H. Soininen
R. Parkkola
fDepartment of Radiology (R.P.), University of Turku and Turku University Hospital, Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Parkkola
T. Ngandu
gDepartment of Public Health Solutions (T.N., M.K.), Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
hDivision of Clinical Geriatrics (T.N., M.K.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T. Ngandu
M. Kivipelto
dDepartment of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland
eNeurocenter (Y.L., H.S., M.K.), Neurology, Kuopio University Hospital, Kuopio, Finland
gDepartment of Public Health Solutions (T.N., M.K.), Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
hDivision of Clinical Geriatrics (T.N., M.K.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Kivipelto
J.O. Rinne
bDivision of Clinical Neurosciences (N.K., J.O.R.), Turku University Hospital, Turku, Finland
cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.O. Rinne
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Sevigny J,
    2. Chiao P,
    3. Bussière T, et al
    . The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature 2016;537:50–56 doi:10.1038/nature19323 pmid:27582220
    CrossRefPubMed
  2. 2.↵
    1. Kemppainen NM,
    2. Aalto S,
    3. Wilson IA, et al
    . PET amyloid ligand [11C] PIB uptake is increased in mild cognitive impairment. Neurology 2007;68:1603–06 doi:10.1212/01.wnl.0000260969.94695.56 pmid:17485647
    Abstract/FREE Full Text
  3. 3.↵
    1. Archer HA,
    2. Edison P,
    3. Brooks DJ, et al
    . Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study. Ann Neurol 2006;60:145–47 doi:10.1002/ana.20889 pmid:16802294
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Tosun D,
    2. Schuff N,
    3. Mathis CA, et al
    ; Alzheimer's Disease Neuroimaging Initiative. Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment. Brain 2011;134:1077–88 doi:10.1093/brain/awr044 pmid:21429865
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Oh H,
    2. Madison C,
    3. Villeneuve S, et al
    . Association of gray matter atrophy with age, β-amyloid, and cognition in aging. Cereb Cortex 2014;24:1609–18 doi:10.1093/cercor/bht017 pmid:23389995
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Storandt M,
    2. Mintun MA,
    3. Head D, et al
    . Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition. Arch Neurol 2009;66:1476–81 pmid:20008651
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Chételat G,
    2. Villemagne VL,
    3. Pike KE, et al
    ; Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) Research Group. Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain 2010;133:3349–58 doi:10.1093/brain/awq187 pmid:20739349
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Jack CR Jr.,
    2. Lowe VJ,
    3. Weigand SD, et al
    ; Alzheimer's Disease Neuroimaging Initiative. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain 2009;132:1355–65 doi:10.1093/brain/awp062 pmid:19339253
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Insel PS,
    2. Mattsson N,
    3. Donohue MC, et al
    . The transitional association between β-amyloid pathology and regional brain atrophy. Alzheimers Dement 2015;11:1171–79 doi:10.1016/j.jalz.2014.11.002 pmid:25499535
    CrossRefPubMed
  10. 10.↵
    1. Kivipelto M,
    2. Ngandu T,
    3. Laatikainen T, et al
    . Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol 2006;5:735–41 doi:10.1016/S1474-4422(06)70537-3 pmid:16914401
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Kivipelto M,
    2. Solomon A,
    3. Ahtiluoto S, et al
    . The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress. Alzheimers Dement 2013;9:657–65 doi:10.1016/j.jalz.2012.09.012 pmid:23332672
    CrossRefPubMed
  12. 12.↵
    1. Ngandu T,
    2. Lehtisalo J,
    3. Solomon A, et al
    . A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 2015;385:2255–63 doi:10.1016/S0140-6736(15)60461-5 pmid:25771249
    CrossRefPubMed
  13. 13.↵
    1. Ngandu T,
    2. Lehtisalo J,
    3. Levälahti E, et al
    . Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-a randomized controlled lifestyle trial. Int J Environ Res Public Health 2014;11:9345–60 doi:10.3390/ijerph110909345 pmid:25211775
    CrossRefPubMed
  14. 14.↵
    1. Harrison J,
    2. Minassian SL,
    3. Jenkins L, et al
    . A neuropsychological test battery for use in Alzheimer disease clinical trials. Arch Neurol 2007;64:1323–29 doi:10.1001/archneur.64.9.1323 pmid:17846273
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. De la Vega FM,
    2. Lazaruk KD,
    3. Rhodes MD, et al
    . Assessment of two flexible and compatible SNP genotyping platforms: TaqMan SNP Genotyping Assays and the SNPlex Genotyping System. Mutat Res 2005;573:111–35 doi:10.1016/j.mrfmmm.2005.01.008 pmid:15829242
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Snellman A,
    2. Rokka J,
    3. López-Picón FR, et al
    . Applicability of [(11)C]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment effects in APP23 mouse model. Neurobiol Aging 2017;57:84–94 doi:10.1016/j.neurobiolaging.2017.05.008 pmid:28605642
    CrossRefPubMed
  17. 17.↵
    1. Schulz V,
    2. Torres-Espallardo I,
    3. Renisch S, et al
    . Automatic, three-segment, MR-based attenuation correction for whole-body PET/MR data. Eur J Nucl Med Mol Imaging 2011;38:138–52 doi:10.1007/s00259-010-1603-1 pmid:20922522
    CrossRefPubMed
  18. 18.↵
    1. Fischl B,
    2. Salat DH,
    3. Busa E, et al
    . Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 2002;33:341–55 doi:10.1016/S0896-6273(02)00569-X pmid:11832223
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Ashburner J,
    2. Friston KJ
    . Unified segmentation. Neuroimage 2005;26:839–51 doi:10.1016/j.neuroimage.2005.02.018 pmid:15955494
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Hayasaka S,
    2. Phan KL,
    3. Liberzon I, et al
    . Nonstationary cluster-size inference with random field and permutation methods. Neuroimage 2004;22:676–87 doi:10.1016/j.neuroimage.2004.01.041 pmid:15193596
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Fazekas F,
    2. Chawluk JB,
    3. Alavi A, et al
    . MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987;149:351–56 doi:10.2214/ajr.149.2.351 pmid:3496763
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Jack CR Jr.,
    2. Lowe VJ,
    3. Senjem ML, et al
    . 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain 2008;131:665–80 doi:10.1093/brain/awm336 pmid:18263627
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Mormino EC,
    2. Kluth JT,
    3. Madison CM, et al
    ; Alzheimer's Disease Neuroimaging Initiative. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain 2009;132:1310–23 doi:10.1093/brain/awn320 pmid:19042931
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Bourgeat P,
    2. Chételat G,
    3. Villemagne VL, et al
    ; AIBL Research Group. Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology 2010;74:121–27 doi:10.1212/WNL.0b013e3181c918b5 pmid:20065247
    Abstract/FREE Full Text
  25. 25.↵
    1. Chételat G,
    2. Villemagne VL,
    3. Bourgeat P, et al
    ; Australian Imaging Biomarkers and Lifestyle Research Group. Relationship between atrophy and beta-amyloid deposition in Alzheimer disease. Ann Neurol 2010;67:317–24 doi:10.1002/ana.21955 pmid:20373343
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Mormino EC,
    2. Betensky RA,
    3. Hedden T, et al
    . Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals. JAMA Neurol 2014;71:1379–85 doi:10.1001/jamaneurol.2014.2031 pmid:25222039
    CrossRefPubMed
  27. 27.↵
    1. Dickerson BC,
    2. Bakkour A,
    3. Salat DH, et al
    . The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex 2009;19:497–510 doi:10.1093/cercor/bhn113 pmid:18632739
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Lerch JP,
    2. Pruessner JC,
    3. Zijdenbos A, et al
    . Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy. Cereb Cortex 2005;15:995–1001 doi:10.1093/cercor/bhh200 pmid:15537673
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Mattsson N,
    2. Insel PS,
    3. Nosheny R, et al
    . Emerging β-amyloid pathology and accelerated cortical atrophy. JAMA Neurol 2014;71:725–34 doi:10.1001/jamaneurol.2014.446 pmid:24781145
    CrossRefPubMed
  30. 30.↵
    1. Galasko D,
    2. Chang L,
    3. Motter R, et al
    . High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype. Arch Neurol 1998;55:937–45 doi:10.1001/archneur.55.7.937 pmid:9678311
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Honea RA,
    2. Vidoni E,
    3. Harsha A, et al
    . Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study. J Alzheimers Dis 2009;18:553–64 doi:10.3233/JAD-2009-1163 pmid:19584447
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Liu Y,
    2. Paajanen T,
    3. Westman E, et al
    ; AddNeuroMed Consortium. Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. J Alzheimers Dis 2010;21:947–66 doi:10.3233/JAD-2010-100201 pmid:20693633
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Becker JA,
    2. Hedden T,
    3. Carmasin J, et al
    . Amyloid-β associated cortical thinning in clinically normal elderly. Ann Neurol 2011;69:1032–42 doi:10.1002/ana.22333 pmid:21437929
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. Falahati F,
    2. Ferreira D,
    3. Muehlboeck JS, et al
    . Monitoring disease progression in mild cognitive impairment: associations between atrophy patterns, cognition, APOE and amyloid. Neuroimage Clin 2017;16:418–28 doi:10.1016/j.nicl.2017.08.014 pmid:28879083
    CrossRefPubMed
  35. 35.↵
    1. Chételat G,
    2. Fouquet M
    . Neuroimaging biomarkers for Alzheimer's disease in asymptomatic APOE4 carriers. Rev Neurol (Paris) 2013;169:729–36 doi:10.1016/j.neurol.2013.07.025 pmid:24016463
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 40 (1)
American Journal of Neuroradiology
Vol. 40, Issue 1
1 Jan 2019
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
I.K. Martikainen, N. Kemppainen, J. Johansson, J. Teuho, S. Helin, Y. Liu, S. Helisalmi, H. Soininen, R. Parkkola, T. Ngandu, M. Kivipelto, J.O. Rinne
Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline
American Journal of Neuroradiology Jan 2019, 40 (1) 80-85; DOI: 10.3174/ajnr.A5891

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline
I.K. Martikainen, N. Kemppainen, J. Johansson, J. Teuho, S. Helin, Y. Liu, S. Helisalmi, H. Soininen, R. Parkkola, T. Ngandu, M. Kivipelto, J.O. Rinne
American Journal of Neuroradiology Jan 2019, 40 (1) 80-85; DOI: 10.3174/ajnr.A5891
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Amyloid PET predicts atrophy in non-demented individuals: Results from the AMYPAD-PNHS
  • Early life factors and dementia risk: A study of adverse childhood experiences and later-life cognition and behaviour
  • Crossref (13)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Molecular Targets in Alzheimer’s Disease
    Geir Bjørklund, Jan Aaseth, Maryam Dadar, Salvatore Chirumbolo
    Molecular Neurobiology 2019 56 10
  • Electroacupuncture Enhances Cognition by Promoting Brain Glucose Metabolism and Inhibiting Inflammation in the APP/PS1 Mouse Model of Alzheimer’s Disease: A Pilot Study
    Anping Xu, Yinshan Tang, Qingtao Zeng, Xin Wang, Huiling Tian, You Zhou, Zhigang Li
    Journal of Alzheimer's Disease 2020 77 1
  • Modeling the Inhibition Kinetics of Curcumin, Orange G, and Resveratrol with Amyloid-β Peptide
    Chandra Mouli R. Madhuranthakam, Arash Shakeri, Praveen P. N. Rao
    ACS Omega 2021 6 12
  • Acupuncture Effect Assessment in APP/PS1 Transgenic Mice: On Regulating Learning-Memory Abilities, Gut Microbiota, and Microbial Metabolites
    Bo Yang, Min He, Xinhua Chen, Mengmeng Sun, Ting Pan, Xiaohong Xu, Xuesong Zhang, Qing Gong, Ye Zhao, Ziqi Jin, Zedong Cheng, Min Tang
    Computational and Mathematical Methods in Medicine 2022 2022
  • Association between brain amyloid accumulation and neuropsychological characteristics in elders with depression and mild cognitive impairment
    HyunChul Youn, Suji Lee, Changsu Han, Seung‐Hyun Kim, Hyun‐Ghang Jeong
    International Journal of Geriatric Psychiatry 2019 34 12
  • Serum Cathepsin D Is a Potential Biomarker for Alzheimer’s Disease Dementia and Cognitive Decline
    Yuek Ling Chai, Nathan Hao Ping Liang, Joyce R. Chong, Narayanaswamy Venketasubramanian, Boon Yeow Tan, Saima Hilal, Christopher P. Chen, Mitchell K. P. Lai
    Journal of Alzheimer's Disease 2023 91 3
  • An Exploratory Study of Cognitive Involvement in Hereditary Transthyretin Amyloidosis
    Hacer Durmuş, Arman Çakar, Hasan Demirci, Merve Alaylioglu, Duygu Gezen‐Ak, Erdinc Dursun, Yeşim Gülşen Parman
    Acta Neurologica Scandinavica 2021 144 6
  • A UK-Wide Study Employing Natural Language Processing to Determine What Matters to People about Brain Health to Improve Drug Development: The Electronic Person-Specific Outcome Measure (ePSOM) Programme
    Stina Saunders, G. Muniz-Terrera, S. Sheehan, C.W. Ritchie, S. Luz
    The Journal of Prevention of Alzheimer's Disease 2021 8 4
  • In Vitro Assessment of the Neuroprotective Effects of Pomegranate (Punica granatum L.) Polyphenols Against Tau Phosphorylation, Neuroinflammation, and Oxidative Stress
    Mehdi Alami, Kaoutar Boumezough, Echarki Zerif, Nada Zoubdane, Abdelouahed Khalil, Ton Bunt, Benoit Laurent, Jacek Witkowski, Charles Ramassamy, Samira Boulbaroud, Tamas Fulop, Hicham Berrougui
    Nutrients 2024 16 21
  • A New Era in Alzheimer' s Research
    Manisha Nahar, Aamir Khan, Ravina Rai, Deepali Jat
    2025

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Cerebral ADC Changes in Fabry Disease
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire