Correlation between 2D and 3D Fetal Brain MRI Biometry and Neurodevelopmental Outcomes in Fetuses with Suspected Microcephaly and Macrocephaly

S. Fried; M. Gafner; D. Jeddah; N. Gosher; D. Hoffman; R. Ber; A. Mayer; E. Katorza

doi:10.3174/ajnr.A7225

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FIG 1.
Scatterplots of the Vineland II Adaptive Behavior standard score according to STV (A), CV (B), OFD (C), and BPD (D). Macrocephalic and normocephalic biometry.
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FIG 2.
Scatterplots of the Vineland II Adaptive Behavior standard score according to STV (A), CV (B), OFD (C), and BPD (D). Microcephalic and normocephalic biometry.

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Table 1:

Descriptive statistics of the study population

Statistics
Maternal age at birth (median) (IQR) (yr)	34 (29.8–36.0)
Fetal sex
Male (No.) (%)	34 (48.6%)
Female (No.) (%)	36 (51.4%)
Abnormal triple test findings (No.) (%)	3 (4.3%)
Abnormal nuchal translucency findings (No.) (%)	3 (4.3%)
Karyotype (No.) (%)
Not performed	31 (44.3%)
Normal findings	39 (55.7%)
Abnormal findings	0 (0%)
Chromosomal microarray (No.) (%)
Not performed	48 (68.6%)
Normal findings	21 (30%)
Abnormal findings	1 (1.4%)
Length of pregnancy (mean) (SD) (wk)	38.8 (1.3)

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Table 2:

2D and 3D fetal brain MR imaging biometric parameters

Characteristics	Median	IQR
OFD (mm)	98.5	93.0–102.3
OFD (centile)	57.5	28.8–90.0
BPD (mm)	77.0	72.8–80.0
BPD (centile)	40.0	10.0–75.0
TCD (mm)	45.0	41.9–48.0
TCD (centile)	50.0	40.0–75.0
STV (mm³)	220.294	192,195–248,017
STV (centile)	28.0	4.0–84.3
CV (mm³)	12.683	10,604–15,114
CV (centile)	48.5	12.8–77.5
CV/STV	0.058	0.052–0.065
CV/STV (centile)	58.5	32.0–88.5

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Table 3:

Comparison of Vineland-II Adaptive Behavior standard scores between fetuses with microcephaly and healthy fetuses according to 2D and 3D fetal brain MR imaging biometry^{^a}

Percentile of biometric value	4–96	≤3	P Value
MR imaging 3D STV (No. of fetuses)	43	16
Adaptive behavior composite score	99 (109–90)	104 (116–91)	.44
MR imaging 3D CV (No. of fetuses)	53	9
Adaptive behavior composite score	99 (111–91)	97 (111–83)	.51
MR imaging 2D OFD (No. of fetuses)	58	1
Adaptive behavior composite score	99 (111–71)	107	NA
MR imaging 2D BPD (No. of fetuses)	61	6
Adaptive behavior composite score	98 (111–89)	104 (108–95)	.68

Note:—NA indicates not applicable.
↵a Continuous variables are presented as median (IQR). P value refers to the Mann-Whitney U test.

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Table 4:

Comparison of Vineland-II Adaptive Behavior standard scores between fetuses with macrocephaly and healthy fetuses according to 2D and 3D fetal brain MR imaging biometry^{^a}

Percentile of biometric value	4–96	≥97	P Value
MR imaging 3D STV (No. of fetuses)	43	11
Adaptive behavior composite standard score	99 (109–90)	98 (109–84)	.31
MR imaging 3D CV (No. of fetuses)	53	8
Adaptive behavior composite standard score	99 (111–91)	94 (106–84)	.19
MR imaging 2D OFD (No. of fetuses)	58	11
Adaptive behavior composite standard score	99 (111–71)	90 (108–86)	.13
MR imaging 2D BPD (No. of fetuses)	61	3
Adaptive behavior composite standard score	98 (111–89)	102	.93