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Research ArticleAdult Brain

Clinical Profiles and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis: A Cluster-Based Approach Based on MR Imaging Metrics

G. Milella, A. Introna, D.M. Mezzapesa, E. D’Errico, A. Fraddosio, M. Ucci, S. Zoccolella and I.L. Simone
American Journal of Neuroradiology April 2023, 44 (4) 403-409; DOI: https://doi.org/10.3174/ajnr.A7823
G. Milella
aFrom the Neurology Unit (G.M., A.I., D.M.M., E.D., A.F., M.U., I.L.S.), Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro,” Bari, Italy
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A. Introna
aFrom the Neurology Unit (G.M., A.I., D.M.M., E.D., A.F., M.U., I.L.S.), Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro,” Bari, Italy
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D.M. Mezzapesa
aFrom the Neurology Unit (G.M., A.I., D.M.M., E.D., A.F., M.U., I.L.S.), Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro,” Bari, Italy
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E. D’Errico
aFrom the Neurology Unit (G.M., A.I., D.M.M., E.D., A.F., M.U., I.L.S.), Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro,” Bari, Italy
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A. Fraddosio
aFrom the Neurology Unit (G.M., A.I., D.M.M., E.D., A.F., M.U., I.L.S.), Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro,” Bari, Italy
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M. Ucci
aFrom the Neurology Unit (G.M., A.I., D.M.M., E.D., A.F., M.U., I.L.S.), Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro,” Bari, Italy
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S. Zoccolella
bAzienda Sanitaria Locale Bari (S.Z.), San Paolo Hospital, Bari, Italy
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I.L. Simone
aFrom the Neurology Unit (G.M., A.I., D.M.M., E.D., A.F., M.U., I.L.S.), Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro,” Bari, Italy
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American Journal of Neuroradiology: 44 (4)
American Journal of Neuroradiology
Vol. 44, Issue 4
1 Apr 2023
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Cite this article
G. Milella, A. Introna, D.M. Mezzapesa, E. D’Errico, A. Fraddosio, M. Ucci, S. Zoccolella, I.L. Simone
Clinical Profiles and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis: A Cluster-Based Approach Based on MR Imaging Metrics
American Journal of Neuroradiology Apr 2023, 44 (4) 403-409; DOI: 10.3174/ajnr.A7823

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ALS Neurodegeneration Patterns: MRI-Based Clusters
G. Milella, A. Introna, D.M. Mezzapesa, E. D’Errico, A. Fraddosio, M. Ucci, S. Zoccolella, I.L. Simone
American Journal of Neuroradiology Apr 2023, 44 (4) 403-409; DOI: 10.3174/ajnr.A7823
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    Expert Systems with Applications 2024 240
  • Differential cortical gray matter changes in early- and late-onset patients with amyotrophic lateral sclerosis
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  • The impact of upper and lower motor neuron burden on diagnostic certainty, and clinical course of spinal-onset amyotrophic lateral sclerosis: a cluster-based approach
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