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Research ArticleUltra-High-Field MRI/Imaging of Epilepsy/Demyelinating Diseases/Inflammation/Infection
Open Access

Glymphatic System Dysfunction in Myelin Oligodendrocyte Glycoprotein Immunoglobulin G Antibody–Associated Disorders: Association with Clinical Disability

Akifumi Hagiwara, Yuji Tomizawa, Yasunobu Hoshino, Kazumasa Yokoyama, Koji Kamagata, Towa Sekine, Kaito Takabayashi, Moto Nakaya, Tomoko Maekawa, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Nobutaka Hattori and Shigeki Aoki
American Journal of Neuroradiology January 2024, 45 (1) 66-71; DOI: https://doi.org/10.3174/ajnr.A8066
Akifumi Hagiwara
aFrom the Department of Radiology (A.H., K.K., T.S, K.T., M.N., T.M., T.A., A.W., S.A.), Juntendo University School of Medicine, Tokyo, Japan
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  • ORCID record for Akifumi Hagiwara
Yuji Tomizawa
bDepartment of Neurology (Y.T., Y.H., N.H.), Juntendo University School of Medicine, Tokyo, Japan
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  • ORCID record for Yuji Tomizawa
Yasunobu Hoshino
bDepartment of Neurology (Y.T., Y.H., N.H.), Juntendo University School of Medicine, Tokyo, Japan
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Kazumasa Yokoyama
cTousei Neurology Center (K.Y.), Shizuoka, Japan
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  • ORCID record for Kazumasa Yokoyama
Koji Kamagata
aFrom the Department of Radiology (A.H., K.K., T.S, K.T., M.N., T.M., T.A., A.W., S.A.), Juntendo University School of Medicine, Tokyo, Japan
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Towa Sekine
aFrom the Department of Radiology (A.H., K.K., T.S, K.T., M.N., T.M., T.A., A.W., S.A.), Juntendo University School of Medicine, Tokyo, Japan
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Kaito Takabayashi
aFrom the Department of Radiology (A.H., K.K., T.S, K.T., M.N., T.M., T.A., A.W., S.A.), Juntendo University School of Medicine, Tokyo, Japan
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Moto Nakaya
aFrom the Department of Radiology (A.H., K.K., T.S, K.T., M.N., T.M., T.A., A.W., S.A.), Juntendo University School of Medicine, Tokyo, Japan
dDepartment of Radiology (M.N.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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Tomoko Maekawa
aFrom the Department of Radiology (A.H., K.K., T.S, K.T., M.N., T.M., T.A., A.W., S.A.), Juntendo University School of Medicine, Tokyo, Japan
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Toshiaki Akashi
aFrom the Department of Radiology (A.H., K.K., T.S, K.T., M.N., T.M., T.A., A.W., S.A.), Juntendo University School of Medicine, Tokyo, Japan
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Akihiko Wada
aFrom the Department of Radiology (A.H., K.K., T.S, K.T., M.N., T.M., T.A., A.W., S.A.), Juntendo University School of Medicine, Tokyo, Japan
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Toshiaki Taoka
eDepartment of Radiology (T.T., S.N.), Nagoya University Graduate School of Medicine, Aichi, Japan.
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Shinji Naganawa
eDepartment of Radiology (T.T., S.N.), Nagoya University Graduate School of Medicine, Aichi, Japan.
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Nobutaka Hattori
bDepartment of Neurology (Y.T., Y.H., N.H.), Juntendo University School of Medicine, Tokyo, Japan
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Shigeki Aoki
aFrom the Department of Radiology (A.H., K.K., T.S, K.T., M.N., T.M., T.A., A.W., S.A.), Juntendo University School of Medicine, Tokyo, Japan
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Article Information

vol. 45 no. 1 66-71
DOI 
https://doi.org/10.3174/ajnr.A8066
PubMed 
38123957

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received June 21, 2023
  • Accepted after revision October 17, 2023
  • Published online December 29, 2023.

Copyright & Usage 
© 2024 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. Akifumi Hagiwaraa,
  2. Yuji Tomizawab,
  3. Yasunobu Hoshinob,
  4. Kazumasa Yokoyamac,
  5. Koji Kamagataa,
  6. Towa Sekinea,
  7. Kaito Takabayashia,
  8. Moto Nakayaa,d,
  9. Tomoko Maekawaa,
  10. Toshiaki Akashia,
  11. Akihiko Wadaa,
  12. Toshiaki Taokae,
  13. Shinji Naganawae,
  14. Nobutaka Hattorib and
  15. Shigeki Aokia
  1. aFrom the Department of Radiology (A.H., K.K., T.S, K.T., M.N., T.M., T.A., A.W., S.A.), Juntendo University School of Medicine, Tokyo, Japan
  2. bDepartment of Neurology (Y.T., Y.H., N.H.), Juntendo University School of Medicine, Tokyo, Japan
  3. cTousei Neurology Center (K.Y.), Shizuoka, Japan
  4. dDepartment of Radiology (M.N.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  5. eDepartment of Radiology (T.T., S.N.), Nagoya University Graduate School of Medicine, Aichi, Japan.
  1. Please address correspondence to Akifumi Hagiwara, MD, Department of Radiology, Juntendo University School of Medicine, 1-2-1, Hongo, Bunkyo-ku, Tokyo, Japan, 113-8421; e-mail: a-hagiwara{at}juntendo.ac.jp; @Akifumi0314
View Full Text

Funding

  • Japan Society for the Promotion of Science

    22K20896; 23K07189
  • Juntendo Research Branding Project

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Akifumi Hagiwara, Yuji Tomizawa, Yasunobu Hoshino, Kazumasa Yokoyama, Koji Kamagata, Towa Sekine, Kaito Takabayashi, Moto Nakaya, Tomoko Maekawa, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Nobutaka Hattori, Shigeki Aoki
Glymphatic System Dysfunction in Myelin Oligodendrocyte Glycoprotein Immunoglobulin G Antibody–Associated Disorders: Association with Clinical Disability
American Journal of Neuroradiology Jan 2024, 45 (1) 66-71; DOI: 10.3174/ajnr.A8066

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Glymphatic Dysfunction in MOGAD
Akifumi Hagiwara, Yuji Tomizawa, Yasunobu Hoshino, Kazumasa Yokoyama, Koji Kamagata, Towa Sekine, Kaito Takabayashi, Moto Nakaya, Tomoko Maekawa, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Nobutaka Hattori, Shigeki Aoki
American Journal of Neuroradiology Jan 2024, 45 (1) 66-71; DOI: 10.3174/ajnr.A8066
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method
    Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Toshiki Nakane, Hisashi Kawai, Shinji Naganawa
    Magnetic Resonance in Medical Sciences 2024 23 3
  • Accumulation of Cerebrospinal Fluid, Ventricular Enlargement, and Cerebral Folate Metabolic Errors Unify a Diverse Group of Neuropsychiatric Conditions Affecting Adult Neocortical Functions
    Lena Ikeda, Adrià Vilaseca Capel, Dhruti Doddaballapur, Jaleel Miyan
    International Journal of Molecular Sciences 2024 25 18
  • The Impact of Sleep Disorders on Glymphatic Function in Parkinson’s Disease Using Diffusion Tensor MRI
    Yuting Li, Teng Zhang, Chao Wang, Leiyu Geng, Tingting Liu, Tong Lu, Shenghong Ju
    Academic Radiology 2025 32 4
  • Impaired glymphatic function in autoimmune glial fibrillary acidic protein astrocytopathy: a prospective analysis
    Xiaofeng Xu, Xiaohong Su, Li Xu, Xiaodong Chen, Dongcheng Li, Junyu Liu, Kai Dai, Jia Liu, Ying Jiang, Fuhua Peng
    Multiple Sclerosis and Related Disorders 2025 99
  • Impaired glymphatic system function in relapsing-remitting multiple Sclerosis: Insights from diffusion tensor imaging along the perivascular space (DTI-ALPS)
    Wenqian Zhao, Xueao Li, Jing Wang, Liufei Yang, Yuchuan Zhuang, Yanbo Dong, Andrey Tulupov, Jing Li, Jubao Sun, Jinghua Li, Kun Lei, Fengshou Zhang, Jianfeng Bao
    Neuroscience 2025

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