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Research ArticleUltra-High-Field MRI/Imaging of Epilepsy/Demyelinating Diseases/Inflammation/Infection

Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis

A.R. Manning, V. Letchuman, M.L. Martin, E. Gombos, T. Robert-Fitzgerald, Q. Cao, P. Raza, C.M. O’Donnell, B. Renner, L. Daboul, P. Rodrigues, M. Ramos, J. Derbyshire, C. Azevedo, A. Bar-Or, E. Caverzasi, P.A. Calabresi, B.A.C. Cree, L. Freeman, R.G. Henry, E.E. Longbrake, J. Oh, N. Papinutto, D. Pelletier, R.D. Samudralwar, S. Suthiphosuwan, M.K. Schindler, M. Bilello, J.W. Song, E.S. Sotirchos, N.L. Sicotte, O. Al-Louzi, A.J. Solomon, D.S. Reich, D. Ontaneda, P. Sati, R.T. Shinohara and the NAIMS Cooperative
American Journal of Neuroradiology March 2025, 46 (3) 620-626; DOI: https://doi.org/10.3174/ajnr.A8510
A.R. Manning
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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V. Letchuman
bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
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M.L. Martin
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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  • ORCID record for M.L. Martin
E. Gombos
cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
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T. Robert-Fitzgerald
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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Q. Cao
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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P. Raza
dCleveland Clinic Lerner College of Medicine (P. Raza, L.D.), Cleveland, Ohio
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  • ORCID record for P. Raza
C.M. O’Donnell
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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B. Renner
cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
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L. Daboul
bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
dCleveland Clinic Lerner College of Medicine (P. Raza, L.D.), Cleveland, Ohio
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P. Rodrigues
eQMENTA Inc. (P. Rodrigues, M.R.), Boston, Massachusetts
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M. Ramos
eQMENTA Inc. (P. Rodrigues, M.R.), Boston, Massachusetts
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J. Derbyshire
fSection on Functional Imaging Methods (J.D.), Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
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C. Azevedo
gDepartment of Neurology (C.A., D.P.), University of Southern California, Los Angeles, California
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A. Bar-Or
hDepartment of Neurology (A.B.-O., R.D.S., M.K.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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E. Caverzasi
i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California
jDepartment of Brain and Behavioral Sciences (E.C.), University of Pavia, Pavia, Italy; Neuroradiology Department, Advanced Imaging and Radiomics Center (E.C.), IRCCS Mondino Foundation, Pavia, Italy
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P.A. Calabresi
kDepartment of Neurology (P.A.C., E.S.S.), Johns Hopkins University, Baltimore, Maryland
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B.A.C. Cree
i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California
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L. Freeman
lDepartment of Neurology, Dell Medical School (L.F.), The University of Texas at Austin, Austin, Texas
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R.G. Henry
i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California
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E.E. Longbrake
mDepartment of Neurology (E.E.L.), Yale University, New Haven, Connecticut
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J. Oh
nDivision of Neurology (J.O.), Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Canada
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N. Papinutto
i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California
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D. Pelletier
gDepartment of Neurology (C.A., D.P.), University of Southern California, Los Angeles, California
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R.D. Samudralwar
hDepartment of Neurology (A.B.-O., R.D.S., M.K.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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S. Suthiphosuwan
oDepartment of Medical Imaging (S.S.), St. Michael’s Hospital, University of Toronto, Toronto, Canada
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M.K. Schindler
hDepartment of Neurology (A.B.-O., R.D.S., M.K.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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M. Bilello
pDepartment of Radiology (M.B., J.W.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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J.W. Song
pDepartment of Radiology (M.B., J.W.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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E.S. Sotirchos
kDepartment of Neurology (P.A.C., E.S.S.), Johns Hopkins University, Baltimore, Maryland
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N.L. Sicotte
cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
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O. Al-Louzi
bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
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A.J. Solomon
qDepartment of Neurological Sciences (A.J.S.), Larner College of Medicine at the University of Vermont, Burlington, Vermont
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D.S. Reich
bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
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D. Ontaneda
rMellen Center for Multiple Sclerosis (D.O.), Cleveland Clinic, Cleveland, Ohio
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P. Sati
bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
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R.T. Shinohara
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
sCenter for Biomedical Image Computing and Analytics (R.T.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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Article Information

vol. 46 no. 3 620-626
DOI 
https://doi.org/10.3174/ajnr.A8510
PubMed 
39332906

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received January 28, 2024
  • Accepted after revision September 3, 2024
  • Published online March 4, 2025.

Copyright & Usage 
© 2025 by American Journal of Neuroradiology

Author Information

  1. A.R. Manninga,
  2. V. Letchumanb,
  3. M.L. Martina,
  4. E. Gombosc,
  5. T. Robert-Fitzgeralda,
  6. Q. Caoa,
  7. P. Razad,
  8. C.M. O’Donnella,
  9. B. Rennerc,
  10. L. Daboulb,d,
  11. P. Rodriguese,
  12. M. Ramose,
  13. J. Derbyshiref,
  14. C. Azevedog,
  15. A. Bar-Orh,
  16. E. Caverzasii,j,
  17. P.A. Calabresik,
  18. B.A.C. Creei,
  19. L. Freemanl,
  20. R.G. Henryi,
  21. E.E. Longbrakem,
  22. J. Ohn,
  23. N. Papinuttoi,
  24. D. Pelletierg,
  25. R.D. Samudralwarh,
  26. S. Suthiphosuwano,
  27. M.K. Schindlerh,
  28. M. Bilellop,
  29. J.W. Songp,
  30. E.S. Sotirchosk,
  31. N.L. Sicottec,
  32. O. Al-Louzib,c,
  33. A.J. Solomonq,
  34. D.S. Reichb,
  35. D. Ontanedar,
  36. P. Satib,c,
  37. R.T. Shinoharaa,s,
  38. the NAIMS Cooperative
  1. aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
  2. bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
  3. cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
  4. dCleveland Clinic Lerner College of Medicine (P. Raza, L.D.), Cleveland, Ohio
  5. eQMENTA Inc. (P. Rodrigues, M.R.), Boston, Massachusetts
  6. fSection on Functional Imaging Methods (J.D.), Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
  7. gDepartment of Neurology (C.A., D.P.), University of Southern California, Los Angeles, California
  8. hDepartment of Neurology (A.B.-O., R.D.S., M.K.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
  9. i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California
  10. jDepartment of Brain and Behavioral Sciences (E.C.), University of Pavia, Pavia, Italy; Neuroradiology Department, Advanced Imaging and Radiomics Center (E.C.), IRCCS Mondino Foundation, Pavia, Italy
  11. kDepartment of Neurology (P.A.C., E.S.S.), Johns Hopkins University, Baltimore, Maryland
  12. lDepartment of Neurology, Dell Medical School (L.F.), The University of Texas at Austin, Austin, Texas
  13. mDepartment of Neurology (E.E.L.), Yale University, New Haven, Connecticut
  14. nDivision of Neurology (J.O.), Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Canada
  15. oDepartment of Medical Imaging (S.S.), St. Michael’s Hospital, University of Toronto, Toronto, Canada
  16. pDepartment of Radiology (M.B., J.W.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
  17. qDepartment of Neurological Sciences (A.J.S.), Larner College of Medicine at the University of Vermont, Burlington, Vermont
  18. rMellen Center for Multiple Sclerosis (D.O.), Cleveland Clinic, Cleveland, Ohio
  19. sCenter for Biomedical Image Computing and Analytics (R.T.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
  1. Please address correspondence to Abigail R. Manning, University of Pennsylvania, 217 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104-6021; e-mail: Abigail.manning{at}students.jefferson.edu
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Funding

  • National Institute of Neurological Disorders and Stroke

    Intramural Research Program
  • Foundation for the National Institutes of Health

    R01MH112847; R01MH123550; R01NS112274; U01NS116776

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  • The Kappa Free Light Chains Index and Central Vein Sign: Two New Biomarkers for Multiple Sclerosis Diagnosis
    Michael Levraut, Cassandre Landes-Chateau, Lydiane Mondot, Mikael Cohen, Christine Lebrun-Frenay
    Neurology and Therapy 2025 14 3
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A.R. Manning, V. Letchuman, M.L. Martin, E. Gombos, T. Robert-Fitzgerald, Q. Cao, P. Raza, C.M. O’Donnell, B. Renner, L. Daboul, P. Rodrigues, M. Ramos, J. Derbyshire, C. Azevedo, A. Bar-Or, E. Caverzasi, P.A. Calabresi, B.A.C. Cree, L. Freeman, R.G. Henry, E.E. Longbrake, J. Oh, N. Papinutto, D. Pelletier, R.D. Samudralwar, S. Suthiphosuwan, M.K. Schindler, M. Bilello, J.W. Song, E.S. Sotirchos, N.L. Sicotte, O. Al-Louzi, A.J. Solomon, D.S. Reich, D. Ontaneda, P. Sati, R.T. Shinohara, the NAIMS Cooperative
Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis
American Journal of Neuroradiology Mar 2025, 46 (3) 620-626; DOI: 10.3174/ajnr.A8510

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Automated vs Manual Central Vein Sign in MS
A.R. Manning, V. Letchuman, M.L. Martin, E. Gombos, T. Robert-Fitzgerald, Q. Cao, P. Raza, C.M. O’Donnell, B. Renner, L. Daboul, P. Rodrigues, M. Ramos, J. Derbyshire, C. Azevedo, A. Bar-Or, E. Caverzasi, P.A. Calabresi, B.A.C. Cree, L. Freeman, R.G. Henry, E.E. Longbrake, J. Oh, N. Papinutto, D. Pelletier, R.D. Samudralwar, S. Suthiphosuwan, M.K. Schindler, M. Bilello, J.W. Song, E.S. Sotirchos, N.L. Sicotte, O. Al-Louzi, A.J. Solomon, D.S. Reich, D. Ontaneda, P. Sati, R.T. Shinohara, the NAIMS Cooperative
American Journal of Neuroradiology Mar 2025, 46 (3) 620-626; DOI: 10.3174/ajnr.A8510
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The Kappa Free Light Chains Index and Central Vein Sign: Two New Biomarkers for Multiple Sclerosis Diagnosis
    Michael Levraut, Cassandre Landes-Chateau, Lydiane Mondot, Mikael Cohen, Christine Lebrun-Frenay
    Neurology and Therapy 2025 14 3

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