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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI

R. Watts, J.M. Steinklein, L. Waldman, X. Zhou and C.G. Filippi
American Journal of Neuroradiology April 2019, 40 (4) 648-651; DOI: https://doi.org/10.3174/ajnr.A5931
R. Watts
aFrom the Department of Radiology (R.W.), University of Vermont, Burlington, Vermont
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J.M. Steinklein
bDepartment of Radiology (J.M.S., L.W., X.Z., C.G.F.), Lenox Hill Hospital and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York.
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L. Waldman
bDepartment of Radiology (J.M.S., L.W., X.Z., C.G.F.), Lenox Hill Hospital and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York.
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X. Zhou
bDepartment of Radiology (J.M.S., L.W., X.Z., C.G.F.), Lenox Hill Hospital and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York.
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C.G. Filippi
bDepartment of Radiology (J.M.S., L.W., X.Z., C.G.F.), Lenox Hill Hospital and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York.
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    Fig 1.

    Quantitative maps of gadolinium tracer across time. The tracer arrived in the cisterna magna between 1 and 3.5 hours after intrathecal injection. Superior parts of the subarachnoid space enhance late, with clearance also delayed.

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    Fig 2.

    The time course of gadolinium concentration for the frontal, temporal, occipital, and parietal lobes. CSF concentration, cortical gray matter, and juxtacortical white matter curves are shown. Juxtacortical white matter is within 3 mm of the cortex. In each case, the CSF tracer concentration is fitted to a γ-variate distribution, while the tissue concentrations are fitted by 2-compartment pharmacokinetic models.

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American Journal of Neuroradiology: 40 (4)
American Journal of Neuroradiology
Vol. 40, Issue 4
1 Apr 2019
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Cite this article
R. Watts, J.M. Steinklein, L. Waldman, X. Zhou, C.G. Filippi
Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI
American Journal of Neuroradiology Apr 2019, 40 (4) 648-651; DOI: 10.3174/ajnr.A5931

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Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI
R. Watts, J.M. Steinklein, L. Waldman, X. Zhou, C.G. Filippi
American Journal of Neuroradiology Apr 2019, 40 (4) 648-651; DOI: 10.3174/ajnr.A5931
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