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Research ArticleAdult Brain

Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI

R. Watts, J.M. Steinklein, L. Waldman, X. Zhou and C.G. Filippi
American Journal of Neuroradiology April 2019, 40 (4) 648-651; DOI: https://doi.org/10.3174/ajnr.A5931
R. Watts
aFrom the Department of Radiology (R.W.), University of Vermont, Burlington, Vermont
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J.M. Steinklein
bDepartment of Radiology (J.M.S., L.W., X.Z., C.G.F.), Lenox Hill Hospital and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York.
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L. Waldman
bDepartment of Radiology (J.M.S., L.W., X.Z., C.G.F.), Lenox Hill Hospital and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York.
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X. Zhou
bDepartment of Radiology (J.M.S., L.W., X.Z., C.G.F.), Lenox Hill Hospital and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York.
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C.G. Filippi
bDepartment of Radiology (J.M.S., L.W., X.Z., C.G.F.), Lenox Hill Hospital and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York.
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REFERENCES

  1. 1.↵
    1. Ross CA,
    2. Poirier MA
    . Protein aggregation and neurodegenerative disease. Nat Med 2004;10(Suppl):S10–17 pmid:15272267
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Iliff JJ,
    2. Wang M,
    3. Liao Y, et al
    . A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 2012;4:147ra111 doi:10.1126/scitranslmed.3003748 pmid:22896675
    Abstract/FREE Full Text
  3. 3.↵
    1. Hawkes CA,
    2. Sullivan PM,
    3. Hands S, et al
    . Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele. PLoS One 2012;7:e41636 doi:10.1371/journal.pone.0041636 pmid:22848551
    CrossRefPubMed
  4. 4.↵
    1. Iliff JJ,
    2. Chen MJ,
    3. Plog BA, et al
    . Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci 2014;34:16180–93 doi:10.1523/JNEUROSCI.3020-14.2014 pmid:25471560
    Abstract/FREE Full Text
  5. 5.↵
    1. Bakker EN,
    2. Bacskai BJ,
    3. Arbel-Ornath M, et al
    . Lymphatic clearance of the brain: perivascular, paravascular and significance for neurodegenerative diseases. Cell Mol Neurobiol 2016;36:181–94 doi:10.1007/s10571-015-0273-8 pmid:26993512
    CrossRefPubMed
  6. 6.↵
    1. Hawkes CA,
    2. Hartig W,
    3. Kacza J, et al
    . Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy. Acta Neuropathol 2011;121:431–43 doi:10.1007/s00401-011-0801-7 pmid:21259015
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Xie L,
    2. Kang H,
    3. Xu Q, et al
    . Sleep drives metabolite clearance from the adult brain. Science 2013;342:373–77 doi:10.1126/science.1241224 pmid:24136970
    Abstract/FREE Full Text
  8. 8.↵
    1. Iliff JJ,
    2. Lee H,
    3. Yu M, et al
    . Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 2013;123:1299–309 doi:10.1172/JCI67677 pmid:23434588
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Eide PK,
    2. Ringstad G
    . MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain. Acta Radiol Open 2015;4:2058460115609635 doi:10.1177/2058460115609635 pmid:26634147
    CrossRefPubMed
  10. 10.↵
    1. Eide PK,
    2. Ringstad G
    . Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: a glymphatic magnetic resonance imaging study. J Cereb Blood Flow Metab 2018; Feb 27:271678X18760974. [Epub ahead of print] doi:10.1177/0271678X18760974 pmid:29485341
    CrossRefPubMed
  11. 11.↵
    1. Ringstad G,
    2. Valnes LM,
    3. Dale AM, et al
    . Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. JCI Insight 2018 Jul 12;3(13). [Epub ahead of print] doi:10.1172/jci.insight.121537 pmid:29997300
    CrossRefPubMed
  12. 12.↵
    1. Ringstad G,
    2. Vatnehol SAS,
    3. Eide PK
    . Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain 2017;140:2691–705 doi:10.1093/brain/awx191 pmid:28969373
    CrossRefPubMed
  13. 13.↵
    1. Cheng HL,
    2. Wright GA
    . Rapid high-resolution T(1) mapping by variable flip angles: accurate and precise measurements in the presence of radiofrequency field inhomogeneity. Magnetic Reson Med 2006;55:566–74 doi:10.1002/mrm.20791 pmid:16450365
    CrossRefPubMed
  14. 14.↵
    1. Lee H,
    2. Mortensen K,
    3. Sanggaard S, et al
    . Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T. Magnetic Reson Med 2018;79:1568–78 doi:10.1002/mrm.26779 pmid:28627037
    CrossRefPubMed
  15. 15.↵
    1. Safriel Y,
    2. Ang R,
    3. Ali M
    . Gadolinium use in spine pain management procedures for patients with contrast allergies: results in 527 procedures. Cardiovasc Intervent Radiol 2008;31:325–31 doi:10.1007/s00270-007-9192-5 pmid:17939000
    CrossRefPubMed
  16. 16.↵
    1. Nacar Dogan S,
    2. Kizilkilic O,
    3. Kocak B, et al
    . Intrathecal gadolinium-enhanced MR cisternography in patients with otorhinorrhea: 10-year experience of a tertiary referral center. Neuroradiology 2018;60:471–77 doi:10.1007/s00234-018-2014-4 pmid:29572604
    CrossRefPubMed
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American Journal of Neuroradiology: 40 (4)
American Journal of Neuroradiology
Vol. 40, Issue 4
1 Apr 2019
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Cite this article
R. Watts, J.M. Steinklein, L. Waldman, X. Zhou, C.G. Filippi
Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI
American Journal of Neuroradiology Apr 2019, 40 (4) 648-651; DOI: 10.3174/ajnr.A5931

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Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI
R. Watts, J.M. Steinklein, L. Waldman, X. Zhou, C.G. Filippi
American Journal of Neuroradiology Apr 2019, 40 (4) 648-651; DOI: 10.3174/ajnr.A5931
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Cited By...

  • T2-weighted T1 mapping and automated segmentation of CSF: Assessment of solute gradients in the healthy brain
  • Heterogeneity in human brain clearance adds resilience against tauopathy - a computational model informed by glymphatic MRI
  • In-silico molecular enrichment and clearance of the human intracranial space
  • Different Glymphatic Kinetics in Spontaneous Intracranial Hypotension
  • Glymphatic dysfunction in multiple sclerosis and its association with disease pathology and disability
  • Preliminary cross-sectional investigations into the human glymphatic system using multiple novel non-contrast MRI methods
  • Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation
  • Intrathecal [64Cu]Cu-albumin PET reveals age-related decline of cerebrospinal fluid (CSF)-lymphatic efflux
  • CSF circulation and dispersion yield rapid clearance from intracranial compartments
  • Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults
  • Intrathecal Use of Gadobutrol for Glymphatic MR Imaging: Prospective Safety Study of 100 Patients
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