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Between April 2013 and September 2015, seventeen children with intracranial tumors were included in this retrospective study. Intravoxel incoherent motion parameters were fitted using 13 b-values for a biexponential model. The perfusion-free diffusion coefficient, pseudodiffusion coefficient, and perfusion fraction were measured in high- and low-grade tumors. The authors found significant correlations between the histology and IVIM parameters of different pediatric intracranial tumors. These results suggest that IVIM imaging reflects cell density and vascularity across different types of pediatric brain tumors. They also demonstrated that both the diffusion and perfusion parameters measured on IVIM imaging are useful for grading intracranial neuroectodermal tumors in pediatric patients.

In this secondary analysis of the CT and MR imaging studies of the prospective, double-blind Lumbar Epidural Steroid Injections for Spinal Stenosis (LESS) trial participants, the authors found no differences in baseline imaging characteristics between those receiving epidural corticosteroid and lidocaine and those receiving lidocaine alone injections. No imaging measures of spinal stenosis were associated with a differential response to corticosteroids, indicating that imaging parameters of spinal stenosis did not predict a response to epidural corticosteroids.