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Research ArticleHead & Neck
Open Access

MRI Findings of Immune Checkpoint Inhibitor–Induced Hypophysitis: Possible Association with Fibrosis

R. Kurokawa, Y. Ota, W. Gonoi, A. Hagiwara, M. Kurokawa, H. Mori, E. Maeda, S. Amemiya, Y. Usui, N. Sato, Y. Nakata, T. Moritani and O. Abe
American Journal of Neuroradiology September 2020, 41 (9) 1683-1689; DOI: https://doi.org/10.3174/ajnr.A6692
R. Kurokawa
aFrom the Department of Radiology (R.K., W.G., E.M., S.A., Y.U., O.A.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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  • ORCID record for R. Kurokawa
Y. Ota
bDivision of Neuroradiology (Y.O., T.M.), Department of Radiology, Michigan Medicine, Ann Arbor, Michigan
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  • ORCID record for Y. Ota
W. Gonoi
aFrom the Department of Radiology (R.K., W.G., E.M., S.A., Y.U., O.A.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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A. Hagiwara
cDepartment of Radiology (A.H.), Juntendo University School of Medicine, Tokyo, Japan
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M. Kurokawa
dDepartment of Radiology (M.K.), Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan
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H. Mori
eDepartment of Radiology (H.M.), Jichi Medical University, Tochigi-ken, Japan
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E. Maeda
aFrom the Department of Radiology (R.K., W.G., E.M., S.A., Y.U., O.A.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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S. Amemiya
aFrom the Department of Radiology (R.K., W.G., E.M., S.A., Y.U., O.A.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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Y. Usui
aFrom the Department of Radiology (R.K., W.G., E.M., S.A., Y.U., O.A.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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N. Sato
fDepartment of Radiology (N.S.), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
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Y. Nakata
gDepartment of Radiology (Y.N.), National Center of Neurology and Psychiatry, Tokyo, Japan.
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T. Moritani
bDivision of Neuroradiology (Y.O., T.M.), Department of Radiology, Michigan Medicine, Ann Arbor, Michigan
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O. Abe
aFrom the Department of Radiology (R.K., W.G., E.M., S.A., Y.U., O.A.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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Article Information

vol. 41 no. 9 1683-1689
DOI 
https://doi.org/10.3174/ajnr.A6692
PubMed 
32763900

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received April 11, 2020
  • Accepted after revision June 2, 2020
  • Published online September 9, 2020.

Copyright & Usage 
© 2020 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. R. Kurokawaa,
  2. Y. Otab,
  3. W. Gonoia,
  4. A. Hagiwarac,
  5. M. Kurokawad,
  6. H. Morie,
  7. E. Maedaa,
  8. S. Amemiyaa,
  9. Y. Usuia,
  10. N. Satof,
  11. Y. Nakatag,
  12. T. Moritanib and
  13. O. Abea
  1. aFrom the Department of Radiology (R.K., W.G., E.M., S.A., Y.U., O.A.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  2. bDivision of Neuroradiology (Y.O., T.M.), Department of Radiology, Michigan Medicine, Ann Arbor, Michigan
  3. cDepartment of Radiology (A.H.), Juntendo University School of Medicine, Tokyo, Japan
  4. dDepartment of Radiology (M.K.), Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan
  5. eDepartment of Radiology (H.M.), Jichi Medical University, Tochigi-ken, Japan
  6. fDepartment of Radiology (N.S.), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
  7. gDepartment of Radiology (Y.N.), National Center of Neurology and Psychiatry, Tokyo, Japan.
  1. Please address correspondence to Wataru Gonoi, MD, Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; e-mail: watapi-tky{at}umin.net
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R. Kurokawa, Y. Ota, W. Gonoi, A. Hagiwara, M. Kurokawa, H. Mori, E. Maeda, S. Amemiya, Y. Usui, N. Sato, Y. Nakata, T. Moritani, O. Abe
MRI Findings of Immune Checkpoint Inhibitor–Induced Hypophysitis: Possible Association with Fibrosis
American Journal of Neuroradiology Sep 2020, 41 (9) 1683-1689; DOI: 10.3174/ajnr.A6692

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MRI Findings of Immune Checkpoint Inhibitor–Induced Hypophysitis: Possible Association with Fibrosis
R. Kurokawa, Y. Ota, W. Gonoi, A. Hagiwara, M. Kurokawa, H. Mori, E. Maeda, S. Amemiya, Y. Usui, N. Sato, Y. Nakata, T. Moritani, O. Abe
American Journal of Neuroradiology Sep 2020, 41 (9) 1683-1689; DOI: 10.3174/ajnr.A6692
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events
    Julie R Brahmer, Hamzah Abu-Sbeih, Paolo Antonio Ascierto, Jill Brufsky, Laura C Cappelli, Frank B Cortazar, David E Gerber, Lamya Hamad, Eric Hansen, Douglas B Johnson, Mario E Lacouture, Gregory A Masters, Jarushka Naidoo, Michele Nanni, Miguel-Angel Perales, Igor Puzanov, Bianca D Santomasso, Satish P Shanbhag, Rajeev Sharma, Dimitra Skondra, Jeffrey A Sosman, Michelle Turner, Marc S Ernstoff
    Journal for ImmunoTherapy of Cancer 2021 9 6
  • Imaging assessment of toxicity related to immune checkpoint inhibitors
    Antonia M. Berz, Sarah Boughdad, Naïk Vietti-Violi, Antonia Digklia, Clarisse Dromain, Vincent Dunet, Rafael Duran
    Frontiers in Immunology 2023 14
  • MRI characteristics of chemotherapy-related central neurotoxicity: a pictorial review
    Mina F. G. Isaac, Rugaiyah Alkhatib, Chi Long Ho
    Insights into Imaging 2024 15 1
  • Clinical and radiological diagnosis of hypophysitis: a review of literature and own data
    A. V. Vorontsov, D. M. Babaeva, V. P. Vladimirova, T. A. Dubovitskaya, A. O. Gavrilova, Zh. E. Belaya, N. G. Mokryshevа
    Problems of Endocrinology 2022 68 2
  • CT imaging findings of anti-PD-1 inhibitor-related enterocolitis.
    Mariko Kurokawa, Ryo Kurokawa, Akifumi Hagiwara, Wataru Gonoi, Shinjiro Harayama, Koichi Koizumi, Koji Yoshino, Tsunekazu Hishima, Akira Baba, Yoshiaki Ota, Osamu Abe, Yasunobu Takaki
    Abdominal Radiology 2021 46 7
  • Case Report: Imaging immune checkpoint inhibitor-induced yin-yang effects in the brain
    K. F. Bol, E. Peeters, C. M. L. van Herpen, H. Westdorp, E. H. J. G. Aarntzen
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  • Imaging findings of immunoglobin G4-related hypophysitis: A case report
    Kun Lv, Xin Cao, Dao-Ying Geng, Jun Zhang
    World Journal of Clinical Cases 2022 10 26
  • Cancer Immunotherapy and Medical Imaging Research Trends from 2003 to 2023: A Bibliometric Analysis
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