OtherPATHOLOGY REVIEW
Neuropathology for the Neuroradiologist: Plaques and Tangles
F.J. Wippold, N. Cairns, K. Vo, D.M. Holtzman and J.C. Morris
American Journal of Neuroradiology January 2008, 29 (1) 18-22; DOI: https://doi.org/10.3174/ajnr.A0781
F.J. Wippold II
N. Cairns
K. Vo
D.M. Holtzman

References
- ↵
- Kircher T, Wormstall H. Alois Alzheimer (1864-1915): student days and first scientific activities. J Geriatr Psychiatry Neurol 1997;10:127–29
- ↵Brannon WL. Alois Alzheimer (1864–1915). I. Contributions to neurology and psychiatry. J S C Med Assoc 1994;90:399–401
- ↵Beach TG. The history of Alzheimer's disease: three debates. J Hist Med Allied Sci 1987;42:327–49
- ↵Small DH, Cappai R. Alois Alzheimer and Alzheimer's disease: a centennial perspective. J Neurochem 2006;99:708–10
- ↵
- ↵Alzheimer A. Über eine eigenartige Erkrankung der Hirnrinde. Allg Zeitschr Psychiatr 1907;64:146–48
- ↵About a peculiar disease of the cerebral cortex: by Alois Alzheimer, 1907 (translated by L. Jarvik and H. Greenson) [in English and German]. Alzheimer Dis Assoc Disord 1987;1:3–8
- ↵Perusini G. Über klinisch und histologisch eigenartige psychische Erkrankungen des späteren Lebensalters. In: Nissl F, Alzheimer A, eds. Histologische und Histopathologische Arbeiten über die Grosshirnrinde: Mit Besonderer Berücksichtigung der Pathologischen Anatomie der Geisteskrankheiten, Band III, H2. Jena, Germany: Gustav Fischer Verlag;1910 :297–352
- ↵Lucci B. The contribution of Gaetano Perusini to the definition of Alzheimer's disease. Ital J Neurol Sci 1998;19:49–52
- ↵Alzheimer A. Über Eigenartige Krankheitsfalle des Spatern Alters. Gesanipte Neurol Psychiatr 1911;4:356–85
- ↵Klünemann HH, Fronhofer W, Wurster H, et al. Alzheimer's second patient: Johann F. and his family. Ann Neurol 2002;52:520–23
- ↵Kraepelin E. Klinische Psychiatrie, part 1. In: Kraepelin E. Psychiatrie: Ein Lehrbuch für Studierende und Artze, Vol. 2. 8 ed. Leipzig, Germany: Barth1910 :627–28
- Tolliss D. Who was Alzheimer? Nurs Times 1994;90:49
- Graeber MB, Kosel S, Grasbon-Frodl E, et al. Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D. Neurogenetics 1998;1:223–28
- ↵Schorer CE. Historical essay: Kraepelin's description of Alzheimer's disease. Int J Aging Hum Dev 1985;21:235–38
- ↵Tonkonogy J, Moak GS. Alois Alzheimer on presenile dementia. J Geriatr Psychiatry Neurol 1988;1:199–206
- ↵Mott RT, Hulette CM. Neuropathology of Alzheimer's disease. Neuroimaging Clin N Am 2005;15:755–65, ix
- ↵Vannoy JF, Greene JA. Alzheimer's disease: a brief history. J Tenn Med Assoc 1989;82:15–17
- Fischer O. Miliare Nekrosen mit drusigen Wucherungen der Neurofibrillen, eine regelmässige Veränderung der Hirnrinde bei seniler Demenz. Monatsschr Psychiatr Neurol 1907;22:361–72
- ↵Goedert M, Spillantini MG. A century of Alzheimer's disease. Science 2006;314:777–81
- ↵Blocq P, Marinesco G. Sur les lesions et la pathgenie de l'epilepsie dite essentialle. Semaine Med 1892;12:445–46
- ↵
- ↵Ellison D, Love S. Dementias. In: Ellison D, Love S, Chimelli L, et al, eds. Neuropathology: A Reference Text of CNS Pathology. Edinburgh, UK: Mosby,2004 :551–84
- ↵Gandy S. The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. J Clin Invest 2005;115:1121–29
- ↵Schechter R, Yen SH, Terry RD. Fibrous astrocytes in senile dementia of the Alzheimer type. J Neuropathol Exp Neurol 1981;40:95–101
- ↵Wippold FJ 2nd, Perry A, Lennerz J. Neuropathology for the neuroradiologist: Rosenthal fibers. AJNR Am J Neuroradiol 2006;27:958–61
- Gomes FCA, Paulin D, Moura Neto V. Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation. Braz J Med Biol Res 1999;32:619–31
- Rutka JT, Murakami M, Dirks PB, et al. Role of glial filaments in cells and tumors of glial origin: a review. J Neurosurg 1997;87:420–30
- ↵Eng LF, Ghirnikar RS, Lee Y. Glial fibrillary acidic protein: GFAP-thirty-one years (1969–2000). Neurochem Res 2000;25:1439–51
- ↵Lowe J, Blanchard A, Morrell K, et al. Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibers in cerebellar astrocytomas, cytoplasmic bodies in muscle, and Mallory bodies in alcoholic liver disease. J Pathol 1988;155:9–15
- Tomokane N, Iwaki T, Tateishi J, et al. Rosenthal fibers share epitopes with alpha B-crystallin, glial fibrillary acidic protein, and ubiquitin, but not vimentin: immunoelectron microscopy with colloidal gold. Am J Pathol 1991;138:875–85
- ↵
- ↵Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991;12:383–88
- ↵Kidd M. Alzheimer's disease: an electron microscopical study. Brain 1964;87:307–20
- ↵Yamaguchi H, Hirai S, Morimatsu M, et al. Diffuse type of senile plaques in the brains of Alzheimer-type dementia. Acta Neuropathol (Berl) 1988;77:113–19
- ↵Armstrong RA. Plaques and tangles and the pathogenesis of Alzheimer's disease. Folia Neuropathol 2006;44:1–11
- ↵Pearce JM. Alzheimer's disease. J Neurol Neurosurg Psychiatry 2000;68:348
- ↵Sheng JG, Zhou XQ, Mrak RE, et al. Progressive neuronal injury associated with amyloid plaque formation in Alzheimer disease. J Neuropathol Exp Neurol 1998;57:714–17
- ↵Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 1991;82:239–59
- ↵
- ↵Delacourte A. Tauopathies: recent insights into old diseases. Folia Neuropathol 2005;43:244–57
- ↵Goedert M, Klug A, Crowther RA. Tau protein, the paired helical filament and Alzheimer's disease. J Alzheimers Dis 2006;9:195–207
- ↵Goedert M, Spillantini MG, Davies SW. Filamentous nerve cell inclusions in neurodegenerative diseases. Curr Opin Neurobiol 1998;8:619–32
- ↵Drachman DA. Aging of the brain, entropy, and Alzheimer disease. Neurology 2006;67:1340–52
- ↵Price JL, Davis PB, Morris JC, et al. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol Aging 1991;12:295–312
- ↵Price JL, Morris JC. Tangles and plaques in nondemented aging and “preclinical” Alzheimer's disease. Ann Neurol 1999;45:358–68
- ↵
- ↵Terry RD, Gonatas NK, Weiss MA. Ultrastructural studies in Alzheimer's presenile dementia. Am J Pathol 1964;44:269–97
- ↵Bayer TA, Wirths O, Majtenyi K, et al. Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport. Brain Pathol 2001;11:1–11
- ↵Sivaprakasam K. Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation. Curr Med Chem 2006;13:2179–88
- ↵Holtzman DM. Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy. J Mol Neurosci 2001;17:147–55
- ↵Golde TE, Eckman CB, Younkin SG. Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochim Biophys Acta 2000;1502:172–87
- ↵Forero DA, Casadesus G, Perry G, et al. Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. J Cell Mol Med 2006;10:796–805
- ↵Mueller SG, Weiner MW, Thal LJ, et al. The Alzheimer's disease neuroimaging initiative. Neuroimaging Clin N Am 2005;15:869–77, xi–ii
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F.J. Wippold, N. Cairns, K. Vo, D.M. Holtzman, J.C. Morris
Neuropathology for the Neuroradiologist: Plaques and Tangles
American Journal of Neuroradiology Jan 2008, 29 (1) 18-22; DOI: 10.3174/ajnr.A0781
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